{
  "id": 19986,
  "label": "malignant Sertoli-Leydig cell tumor of ovary",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0020542",
  "properties": {
    "xrefs": [
      "GARD:0005495",
      "ICD9:239.5",
      "MEDGEN:1825991",
      "Orphanet:99916",
      "SCTID:237795006",
      "UMLS:C5574973"
    ],
    "synonyms": [
      "Androblastoma",
      "Arrhenoblastoma",
      "malignant ovarian Sertoli-Leydig cell tumor",
      "malignant ovarian Sertoli-Leydig cell tumour",
      "ovarian Sertoli-Leydig cell cancer",
      "ovarian Sertoli-Leydig cell tumor, malignant",
      "ovarian malignant Sertoli-Leydig cell tumor",
      "ovarian malignant Sertoli-Leydig cell tumour",
      "ovarian sertoli-Leydig cell tumor, malignant",
      "virilizing ovarian tumor",
      "virilizing ovarian tumour",
      "malignant Sertoli-Leydig cell tumor of the ovary",
      "malignant Sertoli-Leydig cell tumour of the ovary",
      "malignant ovarian sertoli-Leydig cell tumor",
      "malignant ovarian sertoli-Leydig cell tumour"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "Malignant Sertoli-Leydig cell tumor of ovary is a rare malignant sex cord stromal tumor of ovary occurring typically in young women and characterized by manifestations of androgen excess (hirsutism, hair loss, amenorrhea, or oligomenorrhea), when functional."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 18316,
      "label": "malignant sex cord stromal tumor of ovary",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        18448,
        20709
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018816",
          "MEDGEN:233667",
          "NCIT:C8053",
          "Orphanet:35808",
          "UMLS:C1334609"
        ],
        "synonyms": [
          "malignant Sex cord-stromal tumor of ovary",
          "malignant Sex cord-stromal tumor of the ovary",
          "malignant Sex cord-stromal tumour of ovary",
          "malignant Sex cord-stromal tumour of the ovary",
          "malignant ovarian SCST",
          "malignant ovarian Sex cord-stromal neoplasm",
          "malignant ovarian Sex cord-stromal tumor",
          "malignant ovarian Sex cord-stromal tumour",
          "malignant ovarian sex cord-stromal tumor",
          "malignant ovarian sex cord-stromal tumour",
          "ovarian sex cord-stromal tumor, malignant"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Malignant sex cord stromal tumor (SCST) of ovary is a rare ovarian cancer arising from granulosa, theca, sertoli and leydig cells or stromal fibroblasts, occurring at any age and presenting with abdominal or pelvic mass, and characterized (with the exception of fibroma) by the production of sex steroids resulting in manifestations of hormone excess, with a relatively favorable prognosis."
      },
      "child_count": 8,
      "reference_id": "MONDO:0018172"
    },
    {
      "id": 22944,
      "label": "ovarian Sertoli-Leydig cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20204
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027954",
          "MEDGEN:2038",
          "NCIT:C2880",
          "SCTID:254866007",
          "UMLS:C0003810"
        ],
        "synonyms": [
          "Sertoli-Leydig cell tumor of ovary",
          "Sertoli-Leydig cell tumor of the ovary",
          "Sertoli-Leydig cell tumour of ovary",
          "Sertoli-Leydig cell tumour of the ovary",
          "Sertoli-Leydig neoplasm of ovary",
          "Sertoli-Leydig neoplasm of the ovary",
          "androblastoma",
          "arrhenoblastoma",
          "ovarian Sertoli-Leydig cell neoplasm",
          "ovarian Sertoli-Leydig cell tumor"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign or malignant sex cord-stromal tumor arising from the ovary. It is characterized by the presence of neoplastic Leydig cells. Signs and symptoms include hirsutism, menorrhagia and metrorrhagia. It may be associated with trisomy 8."
      },
      "child_count": 1,
      "reference_id": "MONDO:0036595"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 18316,
      "label": "malignant sex cord stromal tumor of ovary"
    },
    {
      "id": 22944,
      "label": "ovarian Sertoli-Leydig cell tumor"
    }
  ]
}