{
  "id": 19988,
  "label": "streptococcal toxic-shock syndrome",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0020544",
  "properties": {
    "xrefs": [
      "GARD:0019709",
      "MEDGEN:575664",
      "MedDRA:10044251",
      "Orphanet:99918",
      "SCTID:240451000",
      "UMLS:C0343532",
      "icd11.foundation:197163558"
    ],
    "synonyms": [
      "Streptococcus caused toxic shock syndrome",
      "Streptococcus toxic shock syndrome",
      "streptococcal TSS"
    ],
    "categories": [
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      }
    ],
    "definition": "Streptococcal toxic-shock syndrome (streptococcal TSS) is an acute disease mediated by the production of superantigenic toxins characterized by the sudden onset of fever and other febrile symptoms, pain, multisystem organ involvement and potentially leading to coma, shock and death due to a Streptococcus pyogenes infection."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 4056,
      "label": "toxic shock syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2838,
        4370
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:14115",
          "GARD:0009560",
          "ICD10CM:A48.3",
          "ICD9:040.82",
          "MEDGEN:109414",
          "MESH:D012772",
          "NCIT:C35498",
          "NORD:1782",
          "Orphanet:36234",
          "SCTID:18504008",
          "UMLS:C0600327",
          "icd11.foundation:114886962"
        ],
        "synonyms": [
          "TSS",
          "TSS, toxic shock syndrome",
          "bacterial TSS",
          "bacterial toxic-shock syndrome",
          "shock syndrome (TSS), toxic",
          "syndrome (TSS), toxic shock",
          "toxic shock syndrome",
          "toxic shock syndrome, (TSS)",
          "staphylococcal toxic shock syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "A rare acute life-threatening systemic bacterial noncontagious illness caused by exotoxins from bacteria of either the Streptococcus pyogenes or Staphylococcus aureus type. It is characterized by high fever, hypotension, rash, multi-organ dysfunction, and cutaneous desquamation during the early convalescent period. The toxins affect the host immune system, causing an exuberant and pathological host inflammatory response. Laboratory findings include leukocytosis, elevated prothrombin time, hypoalbuminemia, hypocalcemia, and pyuria."
      },
      "child_count": 4,
      "reference_id": "MONDO:0001881"
    },
    {
      "id": 20725,
      "label": "streptococcal infection",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20724
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1001476",
          "ICD9:041.00",
          "ICD9:041.09",
          "MEDGEN:20963",
          "MESH:D013290",
          "NCIT:C87062",
          "SCTID:85769006",
          "UMLS:C0038395"
        ],
        "synonyms": [
          "Streptococcus caused disease or disorder",
          "Streptococcus disease or disorder",
          "Streptococcus infectious disease",
          "streptococcal infection",
          "infection, streptococcal",
          "infections, streptococcal"
        ],
        "definition": "Any of the several infectious disorders caused by members of streptococcus, a genus of gram positive bacteria belonging to the family Streptococcaceae. Streptococcal infections are classified into Groups A, B, C, D and G."
      },
      "child_count": 8,
      "reference_id": "MONDO:0021680"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 4056,
      "label": "toxic shock syndrome"
    },
    {
      "id": 20725,
      "label": "streptococcal infection"
    }
  ]
}