{
  "id": 19989,
  "label": "staphylococcal toxic-shock syndrome",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0020545",
  "properties": {
    "xrefs": [
      "GARD:0019710",
      "ICD9:040.89",
      "MEDGEN:811401",
      "MedDRA:10044250",
      "Orphanet:99919",
      "SCTID:240450004",
      "UMLS:C3714602",
      "icd11.foundation:788554020"
    ],
    "synonyms": [
      "Staphylococcus caused toxic shock syndrome",
      "Staphylococcus toxic shock syndrome",
      "staphylococcal TSS"
    ],
    "categories": [
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      }
    ],
    "definition": "Staphylococcal toxic shock syndrome (staphylococcal TSS) is an acute disease mediated by the production of superantigenic toxins, characterized by high fever, skin rash followed by skin peeling, hypotension, vomiting, diarrhea and potentially leading to multisystem organ failure and caused by a Staphylococcus aureus bacterial infection."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 4056,
      "label": "toxic shock syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2838,
        4370
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:14115",
          "GARD:0009560",
          "ICD10CM:A48.3",
          "ICD9:040.82",
          "MEDGEN:109414",
          "MESH:D012772",
          "NCIT:C35498",
          "NORD:1782",
          "Orphanet:36234",
          "SCTID:18504008",
          "UMLS:C0600327",
          "icd11.foundation:114886962"
        ],
        "synonyms": [
          "TSS",
          "TSS, toxic shock syndrome",
          "bacterial TSS",
          "bacterial toxic-shock syndrome",
          "shock syndrome (TSS), toxic",
          "syndrome (TSS), toxic shock",
          "toxic shock syndrome",
          "toxic shock syndrome, (TSS)",
          "staphylococcal toxic shock syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "A rare acute life-threatening systemic bacterial noncontagious illness caused by exotoxins from bacteria of either the Streptococcus pyogenes or Staphylococcus aureus type. It is characterized by high fever, hypotension, rash, multi-organ dysfunction, and cutaneous desquamation during the early convalescent period. The toxins affect the host immune system, causing an exuberant and pathological host inflammatory response. Laboratory findings include leukocytosis, elevated prothrombin time, hypoalbuminemia, hypocalcemia, and pyuria."
      },
      "child_count": 4,
      "reference_id": "MONDO:0001881"
    },
    {
      "id": 17872,
      "label": "staphylococcal toxemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        21346
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021239",
          "MEDGEN:799765",
          "MedDRA:10041932",
          "Orphanet:300579",
          "UMLS:C0854511"
        ]
      },
      "child_count": 5,
      "reference_id": "MONDO:0017592"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 4056,
      "label": "toxic shock syndrome"
    },
    {
      "id": 17872,
      "label": "staphylococcal toxemia"
    }
  ]
}