{
  "id": 19993,
  "label": "gestational choriocarcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0020550",
  "properties": {
    "xrefs": [
      "DOID:2025",
      "GARD:0019712",
      "ICD9:181",
      "MEDGEN:138102",
      "NCIT:C4646",
      "Orphanet:99926",
      "SCTID:417570003",
      "UMLS:C0349557",
      "icd11.foundation:2136066651"
    ],
    "synonyms": [
      "gestational choriocarcinoma",
      "gestational choriocarcinoma (morphologic abnormality)"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      }
    ],
    "definition": "Gestational choriocarcinoma is a gestational trophoblastic tumor (GTT) occurring secondary to pregnancy (ectopic or normal), miscarriage, voluntary termination of pregnancy (VTP) or a hydatidiform mole."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 3637,
      "label": "female reproductive organ cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4279,
        20384
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:120",
          "EFO:1001331",
          "ICD10CM:C51-C58",
          "ICD9:184",
          "MEDGEN:195944",
          "NCIT:C4913",
          "SCTID:126907002",
          "UMLS:C0699889"
        ],
        "synonyms": [
          "cancer of female reproductive organ",
          "female reproductive cancer",
          "female reproductive organ cancer",
          "gynecologic cancer",
          "malignant female reproductive organ neoplasm",
          "malignant female reproductive system neoplasm",
          "malignant female reproductive system tumor",
          "malignant female reproductive system tumour",
          "malignant gynecologic neoplasm",
          "malignant gynecologic tumor",
          "malignant gynecologic tumour",
          "malignant neoplasm of female reproductive organ",
          "malignant neoplasm of female reproductive system",
          "malignant neoplasm of the female reproductive system",
          "malignant tumor of female reproductive system",
          "malignant tumor of the female reproductive system",
          "malignant tumour of female reproductive system",
          "malignant tumour of the female reproductive system"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A primary or metastatic malignant neoplasm involving the female reproductive system. Representative examples include endometrial carcinoma, cervical carcinoma, ovarian carcinoma, uterine corpus leiomyosarcoma, adenosarcoma, malignant mixed mesodermal (mullerian) tumor, and gestational choriocarcinoma."
      },
      "child_count": 18,
      "reference_id": "MONDO:0001416"
    },
    {
      "id": 5475,
      "label": "extragonadal nonseminomatous germ cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5094,
        19983
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5677",
          "GARD:0023567",
          "MEDGEN:233662",
          "NCIT:C8885",
          "UMLS:C1334582"
        ],
        "synonyms": [
          "cancer of extragonadal non-seminomatous germ cell",
          "cancer of the extragonadal non-seminomatous germ cell",
          "extragonadal non-seminomatous germ cell cancer",
          "extragonadal primary Nonseminoma",
          "malignant extragonadal Nonseminoma",
          "malignant extragonadal non-seminomatous germ cell neoplasm",
          "malignant extragonadal non-seminomatous germ cell tumor",
          "malignant extragonadal non-seminomatous germ cell tumour",
          "malignant neoplasm of extragonadal non-seminomatous germ cell",
          "malignant neoplasm of the extragonadal non-seminomatous germ cell",
          "malignant tumor of extragonadal non-seminomatous germ cell",
          "malignant tumor of the extragonadal non-seminomatous germ cell",
          "malignant tumour of extragonadal non-seminomatous germ cell",
          "malignant tumour of the extragonadal non-seminomatous germ cell",
          "primary malignant extragonadal Nonseminoma"
        ],
        "definition": "A malignant non-seminomatous germ cell tumor that develops as a primary tumor in an anatomic site other than the testis or ovary."
      },
      "child_count": 20,
      "reference_id": "MONDO:0003578"
    },
    {
      "id": 6924,
      "label": "choriocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4886,
        6773
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3594",
          "EFO:0002893",
          "GARD:0006059",
          "HP:0100768",
          "ICDO:9100/3",
          "MEDGEN:40278",
          "MESH:D002822",
          "NANDO:2200070",
          "NCIT:C2948",
          "ONCOTREE:BCCA",
          "SCTID:188188009",
          "UMLS:C0008497"
        ],
        "synonyms": [
          "chorioblastoma",
          "choriocarcinoma",
          "choriocarcinoma (disease)",
          "choriocarcinoma, malignant",
          "chorioepithelioma",
          "chorion carcinoma",
          "chorionic carcinoma"
        ],
        "definition": "An aggressive malignant tumor arising from trophoblastic cells. The vast majority of cases arise in the uterus and represent gestational choriocarcinomas that derive from placental trophoblastic cells. Approximately half of the cases develop from a complete hydatidiform mole. A minority of cases arise in the testis or the ovaries. There is often marked elevation of human chorionic gonadotropin (hCG) in the blood. Choriocarcinomas disseminate rapidly through the hematogenous route; the lungs are most frequently affected."
      },
      "child_count": 16,
      "reference_id": "MONDO:0005207"
    },
    {
      "id": 18866,
      "label": "gestational trophoblastic neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4886,
        20384,
        21520
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3590",
          "GARD:0006498",
          "ICD9:630",
          "MEDGEN:210107",
          "MedDRA:10061988",
          "NCIT:C4699",
          "Orphanet:59305",
          "SCTID:609519004",
          "UMLS:C1135868",
          "icd11.foundation:1972855304"
        ],
        "synonyms": [
          "gestational trophoblastic disease",
          "GTN",
          "GTT",
          "gestational trophoblastic tumor",
          "gestational trophoblastic tumour",
          "hydatidiform mole",
          "molar pregnancy"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A diverse group of pregnancy-related tumors characterized by excessive proliferation of trophoblasts. Representative examples include hydatidiform mole, gestational choriocarcinoma, and placental site trophoblastic tumor."
      },
      "child_count": 18,
      "reference_id": "MONDO:0018944"
    }
  ],
  "children": [
    {
      "id": 6111,
      "label": "gestational ovarian choriocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5421,
        16723,
        19993
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7591",
          "GARD:0023917",
          "MEDGEN:274586",
          "NCIT:C40442",
          "UMLS:C1517538"
        ],
        "synonyms": [
          "gestational ovarian choriocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A rare malignant trophoblastic tumor that arises from the ovary as a result of ectopic ovarian pregnancy. There is no germ cell component present."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004294"
    },
    {
      "id": 6292,
      "label": "fallopian tube gestational choriocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5324,
        7759,
        19993
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8186",
          "GARD:0024032",
          "MEDGEN:232186",
          "NCIT:C6278",
          "UMLS:C1333593"
        ],
        "synonyms": [
          "fallopian tube gestational choriocarcinoma",
          "gestational choriocarcinoma of fallopian tube",
          "gestational choriocarcinoma of the fallopian tube"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A malignant trophoblastic tumor that arises from the fallopian tube during pregnancy."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004489"
    },
    {
      "id": 6293,
      "label": "uterine corpus choriocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16836,
        19993
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8187",
          "DOID:8188",
          "GARD:0024033",
          "MEDGEN:234466",
          "NCIT:C27246",
          "ONCOTREE:UCCA",
          "UMLS:C1336904"
        ],
        "synonyms": [
          "body of uterus choriocarcinoma (disease)",
          "body of uterus gestational choriocarcinoma",
          "gestational choriocarcinoma of body of uterus",
          "gestational uterine corpus choriocarcinoma",
          "uterine corpus gestational choriocarcinoma",
          "choriocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "An aggressive malignant tumor arising from trophoblastic cells in the uterus during pregnancy. Approximately half of the cases develop from a complete hydatidiform mole. There is often marked elevation of human chorionic gonadotropin (hCG) in the blood. Choriocarcinomas disseminate rapidly through the hematogenous route; the lungs are most frequently affected."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004491"
    },
    {
      "id": 7897,
      "label": "placental choriocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4303,
        19993
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2024",
          "EFO:1000479",
          "GARD:0024385",
          "MEDGEN:167782",
          "NCIT:C8893",
          "SCTID:448401007",
          "UMLS:C0855173"
        ],
        "synonyms": [
          "choriocarcinoma of the placenta",
          "placenta choriocarcinoma (disease)",
          "placental choriocarcinoma",
          "choriocarcinoma of placenta",
          "placenta choriocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "Choriocarcinoma that develops in the placenta. It is the rarest form of gestational choriocarcinoma. Metastases to the mother and infant may occur."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006374"
    }
  ],
  "roots": [
    {
      "id": 3637,
      "label": "female reproductive organ cancer"
    },
    {
      "id": 5475,
      "label": "extragonadal nonseminomatous germ cell tumor"
    },
    {
      "id": 6924,
      "label": "choriocarcinoma"
    },
    {
      "id": 18866,
      "label": "gestational trophoblastic neoplasm"
    }
  ]
}