{
  "id": 20002,
  "label": "atypical teratoid rhabdoid tumor",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0020560",
  "properties": {
    "xrefs": [
      "DOID:2129",
      "EFO:1002008",
      "GARD:0016926",
      "ICDO:9508/3",
      "MEDGEN:226853",
      "NANDO:2200101",
      "NCIT:C6906",
      "ONCOTREE:ATRT",
      "Orphanet:99966",
      "UMLS:C1266184"
    ],
    "synonyms": [
      "AT/RT",
      "ATRT",
      "ATT/RHT",
      "CNS rhabdoid neoplasm",
      "CNS rhabdoid tumor",
      "CNS rhabdoid tumour",
      "atypical teratoid/rhabdoid tumor",
      "atypical teratoid/rhabdoid tumor (WHO grade IV)",
      "atypical teratoid/rhabdoid tumor (morphologic abnormality)",
      "atypical teratoid/rhabdoid tumour (WHO grade IV)",
      "atypical teratoid/rhabdoid tumour (morphologic abnormality)",
      "central nervous system rhabdoid neoplasm",
      "central nervous system rhabdoid tumor",
      "central nervous system rhabdoid tumour",
      "malignant brain rhabdoid neoplasm",
      "malignant brain rhabdoid tumor",
      "malignant brain rhabdoid tumour",
      "malignant rhabdoid neoplasm of brain",
      "malignant rhabdoid neoplasm of the brain",
      "malignant rhabdoid tumor of brain",
      "malignant rhabdoid tumor of the brain",
      "malignant rhabdoid tumour of brain",
      "malignant rhabdoid tumour of the brain",
      "primary malignant brain rhabdoid neoplasm",
      "primary malignant brain rhabdoid tumor",
      "primary malignant brain rhabdoid tumour",
      "primary malignant rhabdoid neoplasm of brain",
      "primary malignant rhabdoid neoplasm of the brain",
      "primary malignant rhabdoid tumor of brain",
      "primary malignant rhabdoid tumor of the brain",
      "primary malignant rhabdoid tumour of brain",
      "primary malignant rhabdoid tumour of the brain",
      "rhabdoid neoplasm of CNS",
      "rhabdoid neoplasm of central nervous system",
      "rhabdoid neoplasm of the CNS",
      "rhabdoid neoplasm of the central nervous system",
      "rhabdoid tumor of CNS",
      "rhabdoid tumor of central nervous system",
      "rhabdoid tumor of the CNS",
      "rhabdoid tumor of the central nervous system",
      "rhabdoid tumour of CNS",
      "rhabdoid tumour of central nervous system",
      "rhabdoid tumour of the central nervous system",
      "rhabdoid tumor predisposition syndrome",
      "rhabdoid tumour predisposition syndrome"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "Atypical teratoid rhabdoid tumor (ATRT) is a highly malignant central nervous system (CNS) rhabdoid tumor (RT) found almost exclusively in children."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 4336,
      "label": "central nervous system sarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4753,
        18239
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2133",
          "GARD:0023088",
          "MEDGEN:272444",
          "NCIT:C5153",
          "UMLS:C1332892"
        ],
        "synonyms": [
          "CNS sarcoma",
          "central nervous system sarcoma",
          "sarcoma of CNS",
          "sarcoma of central nervous system",
          "sarcoma of the CNS",
          "sarcoma of the central nervous system"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A sarcoma that arises from the central nervous system."
      },
      "child_count": 24,
      "reference_id": "MONDO:0002217"
    },
    {
      "id": 4765,
      "label": "rhabdoid tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7212,
        18239
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3672",
          "EFO:0005701",
          "GARD:0007572",
          "ICDO:8963/3",
          "MEDGEN:64646",
          "MESH:D018335",
          "NANDO:2200057",
          "NCIT:C3808",
          "ONCOTREE:MRT",
          "Orphanet:69077",
          "UMLS:C0206743"
        ],
        "synonyms": [
          "malignant rhabdoid tumor",
          "rhabdoid sarcoma",
          "rhabdoid tumor",
          "rhabdoid cancer"
        ],
        "definition": "An aggressive malignant embryonal neoplasm usually occurring during childhood. It is characterized by the presence of large cells with abundant cytoplasm, large eccentric nucleus, and a prominent nucleolus and it is associated with abnormalities of chromosome 22. It can arise from the central nervous system, kidney, and the soft tissues. The prognosis is poor."
      },
      "child_count": 10,
      "reference_id": "MONDO:0002728"
    }
  ],
  "children": [
    {
      "id": 14260,
      "label": "rhabdoid tumor predisposition syndrome 2",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16983,
        20002,
        24270
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060997",
          "GARD:0018319",
          "MEDGEN:413749",
          "MESH:C567643",
          "NCIT:C178394",
          "OMIM:613325",
          "UMLS:C2750074"
        ],
        "synonyms": [
          "SMARCA4 familial rhabdoid tumor",
          "SMARCA4 familial rhabdoid tumour",
          "familial rhabdoid tumor caused by mutation in SMARCA4",
          "familial rhabdoid tumour caused by mutation in SMARCA4",
          "rhabdoid tumor predisposition syndrome 2",
          "rhabdoid tumor predisposition syndrome type 2",
          "rhabdoid tumour predisposition syndrome type 2",
          "RTPS2"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Any familial rhabdoid tumor in which the cause of the disease is a mutation in the SMARCA4 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0013224"
    }
  ],
  "roots": [
    {
      "id": 4336,
      "label": "central nervous system sarcoma"
    },
    {
      "id": 4765,
      "label": "rhabdoid tumor"
    }
  ]
}