{
  "id": 20033,
  "label": "malabsorption syndrome",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0020598",
  "properties": {
    "xrefs": [
      "EFO:0009554",
      "MEDGEN:44256",
      "MESH:D008286",
      "NCIT:C3214",
      "SCTID:32230006",
      "UMLS:C0024523"
    ],
    "synonyms": [
      "malabsorption",
      "malabsorption syndrome"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      }
    ],
    "definition": "A syndrome resulting from the inadequate absorption of nutrients in the small intestine. Symptoms include abdominal pain, bloating, and diarrhea."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 9,
  "parents": [
    {
      "id": 6756,
      "label": "intestinal disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6151
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5295",
          "EFO:0009431",
          "ICD9:520-579",
          "ICD9:560-569",
          "ICD9:564",
          "ICD9:564.4",
          "ICD9:569",
          "ICD9:569.4",
          "ICD9:569.49",
          "ICD9:569.89",
          "ICD9:569.9",
          "ICD9:570-579",
          "ICD9:575",
          "MEDGEN:7130",
          "MESH:D007410",
          "NCIT:C26801",
          "SCTID:85919009",
          "UMLS:C0021831"
        ],
        "synonyms": [
          "disease of intestine",
          "disease or disorder of intestine",
          "disorder of intestine",
          "intestinal disease",
          "intestinal disorder",
          "intestine disease",
          "intestine disease or disorder",
          "disease, intestinal",
          "diseases, intestinal"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A non-neoplastic or neoplastic disorder that affects the small or large intestine."
      },
      "child_count": 58,
      "reference_id": "MONDO:0005020"
    }
  ],
  "children": [
    {
      "id": 3330,
      "label": "tropical sprue",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        20033
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10607",
          "ICD10CM:K90.1",
          "ICD9:579.1",
          "MEDGEN:21300",
          "MESH:D013182",
          "NCIT:C45428",
          "SCTID:47384003",
          "UMLS:C0038054",
          "icd11.foundation:316377284"
        ],
        "synonyms": [
          "post-infective tropical malabsorption",
          "tropical steatorrhea",
          "idiopathic tropical malabsorption syndrome",
          "tropical enteropathy"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A rare disorder of the digestive tract characterized by malabsorption and anemia. It is likely caused by infection leading to small intestinal mucosal injury, bacterial overgrowth and inflammatory changes. It is most prevalent in residents and visitors to tropical and subtropical climates. Clinical signs include anorexia, abdominal bloating, diarrhea and weight loss. Clinical course may progress to deficiencies of folate, vitamin B12 and iron. Prognosis is favorable with nutrient replacement and antibiotic therapy, however relapses are common."
      },
      "child_count": 0,
      "reference_id": "MONDO:0001078"
    },
    {
      "id": 6659,
      "label": "intestinal disaccharidase deficiency",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20033,
        22979
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9868",
          "EFO:1000060",
          "ICD9:271.3",
          "MEDGEN:675093",
          "NCIT:C34731",
          "SCTID:22169002",
          "UMLS:C0699848"
        ],
        "synonyms": [
          "intestinal disaccharidase deficiency and disaccharide malabsorption",
          "intestinal disaccharide deficiency and disaccharide malabsorption"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "Inherited or acquired disorders of sugar metabolism. Deficiencies of lactase, maltase or sucrase-isomaltase usually occur irreversibly and independent of one another. Congenital deficiencies are rare whereas acquired deficiencies are more common and may be seen following intestinal mucosal brush-border injury. Clinical signs include abdominal cramping, bloating, flatulence and diarrhea following dietary intake of lactose, maltose or sucrose. The clinical course leads to malabsorption of disaccharides which has implications for normal growth and development if manifested at an early age."
      },
      "child_count": 2,
      "reference_id": "MONDO:0004905"
    },
    {
      "id": 6854,
      "label": "celiac disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3004,
        5714,
        20033,
        21546
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10608",
          "EFO:0001060",
          "ICD10CM:K90.0",
          "ICD9:579.0",
          "MEDGEN:3291",
          "MESH:D002446",
          "NCIT:C26714",
          "OMIMPS:212750",
          "Orphanet:555",
          "SCTID:396331005",
          "UMLS:C0007570",
          "icd11.foundation:2005943638"
        ],
        "synonyms": [
          "celiac disease",
          "celiac sprue",
          "coeliac sprue",
          "gluten intolerance",
          "gluten-induced enteropathy",
          "non tropical sprue"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "An autoimmune genetic disorder with an unknown pattern of inheritance that primarily affects the digestive tract. It is caused by intolerance to dietary gluten. Consumption of gluten protein triggers an immune response which damages small intestinal villi and prevents adequate absorption of nutrients. Clinical signs include abdominal cramping, diarrhea or constipation and weight loss. If untreated, the clinical course may progress to malnutrition, anemia, osteoporosis and an increased risk of intestinal malignancies. However, the prognosis is favorable with successful avoidance of gluten in the diet."
      },
      "child_count": 4,
      "reference_id": "MONDO:0005130"
    },
    {
      "id": 7307,
      "label": "blind loop syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        20033
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10606",
          "EFO:0007175",
          "ICD9:579.2",
          "MEDGEN:600",
          "MESH:D001765",
          "NCIT:C34431",
          "SCTID:66379009",
          "UMLS:C0005750",
          "icd11.foundation:1719064637"
        ],
        "synonyms": [
          "blind loop syndrome",
          "stasis (blind loop) syndrome",
          "stasis syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A disorder affecting the small intestine. It is caused by the stasis of food and subsequent overgrowth of bacteria in a portion of the small intestine that is unintentionally bypassed as a complication of abdominal surgery or as a sequela of gastrointestinal disorders which impede effective motility. Clinical signs include bloating, abdominal pain, diarrhea and weight loss. If untreated, the clinical course progresses to malabsorption of fats, vitamin B12 and calcium, the latter which predisposes to nephrolithiasis and osteoporosis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005673"
    },
    {
      "id": 10481,
      "label": "hereditary folate malabsorption",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3888,
        17107,
        17632,
        20033
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0111678",
          "GARD:0012983",
          "MEDGEN:83348",
          "MESH:C562799",
          "NANDO:1200810",
          "NANDO:2200592",
          "NCIT:C156424",
          "OMIM:229050",
          "Orphanet:90045",
          "SCTID:62578003",
          "UMLS:C0342705",
          "icd11.foundation:773545237"
        ],
        "synonyms": [
          "congenital folate malabsorption",
          "congenital defect of folate absorption",
          "folate malabsorption, hereditary",
          "folic acid transport defect"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Hereditary folate malabsorption (HFM) is an inherited disorder of folate transport characterized by a systemic and central nervous system (CNS) folate deficiency manifesting as megaloblastic anemia, failure to thrive, diarrhea and/or oral mucositis, immunologic dysfunction and neurological disorders."
      },
      "child_count": 0,
      "reference_id": "MONDO:0009238"
    },
    {
      "id": 10764,
      "label": "lysine malabsorption syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5714,
        20033
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:167097",
          "MESH:C563080",
          "OMIM:247950",
          "UMLS:C0796023"
        ],
        "synonyms": [
          "lysine malabsorption syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0009542"
    },
    {
      "id": 19223,
      "label": "idiopathic malabsorption due to bile acid synthesis defects",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19085,
        20033,
        24405
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019046",
          "MEDGEN:900722",
          "Orphanet:84065",
          "UMLS:C4274509"
        ],
        "synonyms": [
          "idiopathic bile acid malabsorption"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "Idiopathic malabsorption due to increased acid bile synthesis is an intestinal disease of unknown etiology characterized by an overproduction of bile acids which leads to chronic watery diarrhea."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019393"
    },
    {
      "id": 19530,
      "label": "autoimmune enteropathy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3004,
        20033
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0008689",
          "ICD9:279.49",
          "MEDGEN:83322",
          "MESH:C538273",
          "NANDO:2200923",
          "NCIT:C94694",
          "Orphanet:94075",
          "SCTID:235728001",
          "UMLS:C0341305"
        ],
        "synonyms": [
          "immune-mediated protracted diarrhea of infancy",
          "immune-mediated protracted diarrhoea of infancy",
          "severe immune-mediated enteropathy"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "Severe-immune mediated enteropathy describes a variety of intestinal disorders that can range from a serious, early-onset systemic disease (IPEX) to a mild isolated gastrointestinal disease. In children it manifests with severe diarrhea and dehydration in the presence of characteristic antibodies (anti-enterocyte and anti-goblet cell) and in adults with chronic diarrhea, malabsorption and weight loss."
      },
      "child_count": 8,
      "reference_id": "MONDO:0019787"
    },
    {
      "id": 24073,
      "label": "lactose intolerance",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6861,
        19082,
        20033
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10604",
          "EFO:1000062",
          "HP:0004789",
          "ICD10CM:E73",
          "ICD10WHO:E73",
          "ICD9:271.3",
          "MEDGEN:6001",
          "MESH:D007787",
          "NCIT:C3154",
          "SCTID:267425008",
          "UMLS:C0022951",
          "icd11.foundation:1026224967"
        ],
        "synonyms": [
          "lactose intolerance",
          "lactose intolerance (disease)",
          "lactase persistence"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ]
      },
      "child_count": 3,
      "reference_id": "MONDO:0100345"
    }
  ],
  "roots": [
    {
      "id": 6756,
      "label": "intestinal disorder"
    }
  ]
}