{
  "id": 20034,
  "label": "acquired coagulation factor deficiency",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0020599",
  "properties": {
    "xrefs": [
      "GARD:0025183",
      "ICD10CM:D68.4",
      "MEDGEN:98",
      "NANDO:1200896",
      "NCIT:C34347",
      "SCTID:25904003",
      "UMLS:C0001169"
    ],
    "synonyms": [
      "acquired coagulation factor deficiency",
      "acquired coagulation protein disease"
    ],
    "categories": [
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "Deficiency of a coagulation factor that is not caused by genetic alterations. Causes include vitamin K deficiency, amyloidosis, and severe liver disease."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 6,
  "parents": [
    {
      "id": 4359,
      "label": "coagulation protein disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3738
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2212",
          "GARD:0023096",
          "MEDGEN:108723",
          "MESH:D020147",
          "NCIT:C27215",
          "SCTID:86075001",
          "UMLS:C0600503"
        ],
        "synonyms": [
          "coagulation factor deficiency",
          "coagulation factor deficiency syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Congenital or acquired deficiency of one of the coagulation factors. It results in bleeding."
      },
      "child_count": 28,
      "reference_id": "MONDO:0002242"
    }
  ],
  "children": [
    {
      "id": 19017,
      "label": "acquired hemophilia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4360,
        18652,
        20034
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0010350",
          "ICD10CM:D68.311",
          "MEDGEN:204253",
          "MedDRA:10053745",
          "NANDO:1200898",
          "Orphanet:73274",
          "UMLS:C1096116"
        ],
        "synonyms": [
          "acquired hemophilia",
          "hemophilia, acquired"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Acquired hemophilia is a bleeding disorder that interferes with the body's blood clotting process. Signs and symptoms include prolonged bleeding, frequent nosebleeds, bruising throughout the body, solid swellings of congealed blood (hematomas), hematuria, and gastrointestinal or urologic bleeding. Acquired hemophilia occurs when the body's immune system attacks and disables a certain protein that helps the blood clot. About half of the cases are associated with other conditions, such as pregnancy, autoimmune disease, cancer, skin diseases, or allergic reactions to medications."
      },
      "child_count": 9,
      "reference_id": "MONDO:0019139"
    },
    {
      "id": 19919,
      "label": "acquired von willebrand syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4360,
        20034,
        21519
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0111146",
          "GARD:0005573",
          "MEDGEN:543999",
          "MedDRA:10069495",
          "NANDO:1200899",
          "Orphanet:99147",
          "PMID:28028990",
          "SCTID:234451005",
          "UMLS:C0272362"
        ],
        "synonyms": [
          "acquired von Willebrand disease",
          "acquired von Willebrand disease (hereditary or acquired)",
          "acquired von willebrand disease",
          "Willebrand disease, acquired"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Acquired von Willebrand syndrome (AVWS) is a bleeding disorder marked by the same biological anomalies as those seen in hereditary von Willebrand disease (VWD) but which occurs in association with another underlying pathology, generally in elderly patients without any personal or family history of bleeding anomalies."
      },
      "child_count": 0,
      "reference_id": "MONDO:0020460"
    },
    {
      "id": 20371,
      "label": "acquired factor XIII deficiency",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4358,
        20034
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0022412",
          "MEDGEN:1393253",
          "NANDO:1200897",
          "NCIT:C131629",
          "Orphanet:599513",
          "UMLS:C0238120",
          "icd11.foundation:939366157"
        ],
        "synonyms": [
          "aFXIII",
          "acquired factor XIII deficiency"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "An acquired coagulation disorder due to reduced levels and activity of factor XIII."
      },
      "child_count": 0,
      "reference_id": "MONDO:0021133"
    },
    {
      "id": 20372,
      "label": "acquired factor X deficiency",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4364,
        20034
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0022410",
          "ICD9:286.9",
          "MEDGEN:543977",
          "NANDO:1201048",
          "NCIT:C131626",
          "Orphanet:599501",
          "SCTID:33820001",
          "UMLS:C0272328"
        ],
        "synonyms": [
          "aFX",
          "acquired factor X deficiency"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "An bleeding disorder with a decreased antigen and/or activity of factor X (FX) that is acquired. Acquired factor X deficiency is a rare disorder, commonly associated with a preceding viral illness and a circulating FX inhibitor. Although multiple treatment modalities have been described with variable success, in many cases, it is a self-limited condition."
      },
      "child_count": 0,
      "reference_id": "MONDO:0021134"
    },
    {
      "id": 22899,
      "label": "acquired factor V deficiency",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        20023,
        20034
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0022408",
          "MEDGEN:1380582",
          "NCIT:C131624",
          "Orphanet:599490",
          "UMLS:C4329256",
          "icd11.foundation:99894028"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0035737"
    },
    {
      "id": 22900,
      "label": "acquired factor VII deficiency",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4361,
        20034
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0022409",
          "MEDGEN:1388639",
          "NCIT:C131625",
          "Orphanet:599495",
          "UMLS:C4331989"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0035738"
    }
  ],
  "roots": [
    {
      "id": 4359,
      "label": "coagulation protein disease"
    }
  ]
}