{
  "id": 20048,
  "label": "anaplastic cancer",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0020633",
  "properties": {
    "xrefs": [
      "MEDGEN:231373",
      "NCIT:C36025",
      "UMLS:C1332287"
    ],
    "synonyms": [
      "anaplastic malignant neoplasm"
    ]
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 8,
  "parents": [
    {
      "id": 6733,
      "label": "cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6798
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050686",
          "DOID:0050687",
          "DOID:162",
          "ICD9:195.8",
          "ICD9:199",
          "ICD9:199.1",
          "ICDO:8000/3",
          "MEDGEN:14297",
          "NCIT:C9305",
          "ONCOTREE:MT",
          "SCTID:363346000",
          "UMLS:C0006826",
          "birnlex:406"
        ],
        "synonyms": [
          "CA",
          "cancer",
          "cell type cancer",
          "malignancy",
          "malignant growth",
          "malignant neoplasm",
          "malignant neoplasm (disease)",
          "malignant neoplastic disease",
          "malignant tumor",
          "malignant tumour",
          "neoplasm (disease), malignant",
          "neoplasm, malignant",
          "MT"
        ],
        "definition": "A tumor composed of atypical neoplastic, often pleomorphic cells that invade other tissues. Malignant neoplasms often metastasize to distant anatomic sites and may recur after excision. The most common malignant neoplasms are carcinomas (adenocarcinomas or squamous cell carcinomas), Hodgkin and non-Hodgkin lymphomas, leukemias, melanomas, and sarcomas."
      },
      "child_count": 33,
      "reference_id": "MONDO:0004992"
    }
  ],
  "children": [
    {
      "id": 7693,
      "label": "central nervous system anaplastic large cell lymphoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19798,
        20048,
        23470
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000156",
          "GARD:0024302",
          "MEDGEN:235493",
          "NCIT:C5322",
          "UMLS:C1335476"
        ],
        "synonyms": [
          "anaplastic CNS large cell lymphoma",
          "anaplastic central nervous system large cell lymphoma",
          "anaplastic large cell lymphoma of CNS",
          "anaplastic large cell lymphoma of central nervous system",
          "anaplastic large cell lymphoma of the CNS",
          "anaplastic large cell lymphoma of the central nervous system",
          "central nervous system anaplastic large cell lymphoma",
          "primary CNS anaplastic large cell lymphoma",
          "primary central nervous system anaplastic large cell lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "An anaplastic large cell lymphoma that affects the brain, meninges, or spinal cord."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006128"
    },
    {
      "id": 7925,
      "label": "sarcomatoid carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6734,
        20048,
        20076
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4015",
          "EFO:1000520",
          "ICDO:8032/3",
          "ICDO:8033/3",
          "MEDGEN:60009",
          "NCIT:C27004",
          "UMLS:C0205697"
        ],
        "synonyms": [
          "carcinoma, spindle cell, malignant",
          "pseudosarcomatous carcinoma",
          "sarcomatoid carcinoma",
          "spindle cell carcinoma",
          "spindle cell carcinoma (morphologic abnormality)"
        ],
        "definition": "A malignant epithelial neoplasm characterized by the presence of spindle cells and anaplastic morphologic features. Giant cells and a sarcomatous component may also be present."
      },
      "child_count": 24,
      "reference_id": "MONDO:0006406"
    },
    {
      "id": 17148,
      "label": "anaplastic astrocytoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        17144,
        19525,
        20048
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3078",
          "EFO:0002499",
          "GARD:0005860",
          "ICDO:9401/3",
          "MEDGEN:137784",
          "MedDRA:10002224",
          "MedDRA:10060971",
          "NANDO:2200086",
          "NCIT:C9477",
          "NORD:769",
          "ONCOTREE:AASTR",
          "Orphanet:251589",
          "UMLS:C0334579"
        ],
        "synonyms": [
          "anaplastic astrocytoma",
          "astrocytoma, anaplastic, malignant",
          "grade III astrocytic neoplasm",
          "grade III astrocytic tumor",
          "grade III astrocytic tumour",
          "grade III astrocytoma",
          "malignant astrocytoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Anaplastic astrocytoma is a rare, high-grade, malignant glial tumor, histologically characterized by abundance of pleomorphic astrocytes and multiple mitotic figures, often associated with diffuse infiltration of the surrounding tissue, considerable edema and mass effect and involvement of the contralateral brain. Depending on the primary localization of the tumor, patients can present with signs of raised intracranial pressure (headache, vomiting, papilledema), seizures, progressive neurological deficits, and/or behavioral changes. The tumor is most commonly localized in the frontal and temporal lobes, brain stem and spinal cord."
      },
      "child_count": 9,
      "reference_id": "MONDO:0016684"
    },
    {
      "id": 17159,
      "label": "anaplastic oligodendroglioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        18713,
        20048,
        20696
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7154",
          "EFO:0002501",
          "GARD:0009472",
          "ICDO:9451/3",
          "MEDGEN:90812",
          "MedDRA:10026659",
          "NCIT:C4326",
          "ONCOTREE:AODG",
          "Orphanet:251630",
          "UMLS:C0334590"
        ],
        "synonyms": [
          "WHO grade III oligodendroglial neoplasm",
          "WHO grade III oligodendroglial tumor",
          "WHO grade III oligodendroglial tumour",
          "anaplastic oligodendroglioma",
          "malignant oligodendroglioma",
          "oligodendroglioma, anaplastic, malignant",
          "oligodendroglioma, malignant",
          "undifferentiated oligodendroglioma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A WHO grade III oligodendroglioma with focal or diffuse malignant morphologic features (prominent nuclear pleomorphism, mitoses, and increased cellularity)."
      },
      "child_count": 3,
      "reference_id": "MONDO:0016696"
    },
    {
      "id": 17163,
      "label": "anaplastic ependymoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5210,
        20048,
        20696
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5074",
          "DOID:5889",
          "GARD:0010634",
          "ICDO:9392/3",
          "MEDGEN:128891",
          "MedDRA:10014968",
          "NCIT:C4049",
          "ONCOTREE:APE",
          "Orphanet:251646",
          "UMLS:C0280788"
        ],
        "synonyms": [
          "ependymal tumors",
          "ependymal tumours",
          "WHO grade III ependymal neoplasm",
          "WHO grade III ependymal tumor",
          "WHO grade III ependymal tumour",
          "anaplastic ependymal neoplasm",
          "anaplastic ependymal tumor",
          "anaplastic ependymal tumour",
          "anaplastic ependymoma",
          "ependymoma, anaplastic, malignant",
          "ependymoma, malignant",
          "high-grade ependymoma",
          "malignant ependymoma",
          "undifferentiated ependymal neoplasm",
          "undifferentiated ependymal tumor",
          "undifferentiated ependymal tumour",
          "undifferentiated ependymoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Anaplastic ependymoma is a rare, malignant type of ependymoma that most often arises in the supratentorial region of the brain of children and young adults and that manifests with variable symptoms including headaches, nausea, vision impairment, memory loss and difficulty walking."
      },
      "child_count": 9,
      "reference_id": "MONDO:0016700"
    },
    {
      "id": 17165,
      "label": "anaplastic oligoastrocytoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7464,
        17164,
        20048,
        20696
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0002500",
          "GARD:0010637",
          "MEDGEN:96556",
          "NCIT:C6959",
          "ONCOTREE:AOAST",
          "Orphanet:251663",
          "UMLS:C0431108"
        ],
        "synonyms": [
          "WHO grade III mixed glioma",
          "aMOA",
          "anaplastic mixed glioma",
          "anaplastic oligoastrocytoma",
          "AOAST"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An oligoastrocytoma characterized by the presence of increased cellularity, nuclear atypia, pleomorphism, and high mitotic activity."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016703"
    },
    {
      "id": 17878,
      "label": "primary cutaneous anaplastic large cell lymphoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3019,
        18825,
        19798,
        20048
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021247",
          "MEDGEN:266255",
          "MESH:D054446",
          "MedDRA:10065863",
          "NCIT:C6860",
          "ONCOTREE:PCALCL",
          "Orphanet:300865",
          "UMLS:C1301362",
          "icd11.foundation:1972636482"
        ],
        "synonyms": [
          "ALCL, cutaneous",
          "C-ALCL",
          "anaplastic large-cell lymphoma, primary cutaneous type",
          "primary C-ALCL",
          "primary anaplastic large cell lymphoma of skin",
          "primary anaplastic large cell lymphoma of the skin",
          "primary cutaneous CD30 Positive anaplastic large cell lymphoma",
          "primary cutaneous CD30+ ALCL",
          "primary cutaneous CD30+ anaplastic large cell lymphoma",
          "regressive atypical histiocytosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Primary cutaneous anaplastic large cell lymphoma (C-ALCL) is a rare T-cell non-Hodgkin lymphoma that affects the skin and generally shows no extracutaneous involvement at presentation. It belongs to the spectrum of primary cutaneous CD30+ lymphoproliferative disorders along with lymphomatoid papulosis with which it shares overlapping clinical and histopathologic features."
      },
      "child_count": 0,
      "reference_id": "MONDO:0017598"
    },
    {
      "id": 20050,
      "label": "anaplastic meningioma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        20048,
        20049,
        20078,
        20501
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025191",
          "ICDO:9530/3",
          "MEDGEN:75478",
          "NCIT:C4051",
          "ONCOTREE:ANM",
          "UMLS:C0259785"
        ],
        "synonyms": [
          "anaplastic (malignant) meningioma",
          "anaplastic meningioma",
          "malignant meningioma",
          "meningioma, anaplastic, malignant",
          "meningioma, malignant"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A WHO grade III meningioma characterized by the presence of malignant morphologic features, including malignant cytology and a very high mitotic index (20 or more mitoses per ten high power fields)."
      },
      "child_count": 0,
      "reference_id": "MONDO:0020635"
    }
  ],
  "roots": [
    {
      "id": 6733,
      "label": "cancer"
    }
  ]
}