{
  "id": 20049,
  "label": "grade III meningioma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0020634",
  "properties": {
    "xrefs": [
      "GARD:0025190",
      "MEDGEN:79186",
      "NCIT:C38938",
      "UMLS:C0280801"
    ],
    "synonyms": [
      "WHO grade III meningioma",
      "grade 3 meningioma",
      "grade III meningioma",
      "meningioma, malignant"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "A malignant meningioma with aggressive clinical course. It recurs in approximately 50-78% of the cases. This category includes the anaplastic (malignant) meningioma, papillary meningioma, and rhabdoid meningioma."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 17113,
      "label": "meningioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        17192
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3565",
          "GARD:0007015",
          "HP:0002858",
          "ICDO:9530/0",
          "MEDGEN:7532",
          "MESH:D008579",
          "MedDRA:10027191",
          "NANDO:2200094",
          "NCIT:C3230",
          "NORD:1434",
          "ONCOTREE:MNG",
          "Orphanet:2495",
          "SCTID:302820008",
          "UMLS:C0025286",
          "icd11.foundation:672106711"
        ],
        "synonyms": [
          "meningioma",
          "meningioma (disease)",
          "intracranial meningioma",
          "meningeal neoplasm",
          "meningothelial cell tumor",
          "meningothelial cell tumour",
          "primary meningeal tumor",
          "primary meningeal tumour",
          "supratentorial meningioma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A generally slow growing tumor attached to the dura mater. It is composed of neoplastic meningothelial (arachnoidal) cells. It typically occurs in adults, often women and it has a wide range of histopathological appearances. Of the various subtypes, meningothelial, fibrous and transitional meningiomas are the most common. Most meningiomas are WHO grade I tumors, and some are WHO grade II or III tumors. Most subtypes share a common clinical behavior, although some subtypes are more likely to recur and follow a more aggressive clinical course. (Adapted from WHO)"
      },
      "child_count": 37,
      "reference_id": "MONDO:0016642"
    }
  ],
  "children": [
    {
      "id": 20050,
      "label": "anaplastic meningioma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        20048,
        20049,
        20078,
        20501
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025191",
          "ICDO:9530/3",
          "MEDGEN:75478",
          "NCIT:C4051",
          "ONCOTREE:ANM",
          "UMLS:C0259785"
        ],
        "synonyms": [
          "anaplastic (malignant) meningioma",
          "anaplastic meningioma",
          "malignant meningioma",
          "meningioma, anaplastic, malignant",
          "meningioma, malignant"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A WHO grade III meningioma characterized by the presence of malignant morphologic features, including malignant cytology and a very high mitotic index (20 or more mitoses per ten high power fields)."
      },
      "child_count": 0,
      "reference_id": "MONDO:0020635"
    }
  ],
  "roots": [
    {
      "id": 17113,
      "label": "meningioma"
    }
  ]
}