{
  "id": 20055,
  "label": "autoimmune encephalitis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0020640",
  "properties": {
    "xrefs": [
      "GARD:0011979",
      "MEDGEN:1804547",
      "NANDO:2100248",
      "NANDO:2200902",
      "NCIT:C122414",
      "Orphanet:622014",
      "SCTID:95643007",
      "UMLS:C5671289",
      "icd11.foundation:241281019"
    ],
    "synonyms": [
      "autoimmune encephalitis"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "Inflammation of the brain secondary to an immune response triggered by the body itself."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 2996,
      "label": "autoimmune disorder of central nervous system",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4657,
        4981
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060004",
          "EFO:0020092"
        ],
        "synonyms": [
          "central nervous system autoimmune disease",
          "central nervous system hypersensitivity reaction type II disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A hypersensitivity reaction type II disease that involves the central nervous system."
      },
      "child_count": 16,
      "reference_id": "MONDO:0000568"
    },
    {
      "id": 19673,
      "label": "encephalitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6880,
        7209,
        20092
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9588",
          "ICD10CM:A85",
          "ICD9:323.0",
          "ICD9:323.8",
          "ICD9:323.9",
          "MEDGEN:4027",
          "MESH:D004660",
          "MedDRA:10014581",
          "NCIT:C26760",
          "Orphanet:97275",
          "SCTID:45170000",
          "UMLS:C0014038"
        ],
        "synonyms": [
          "brain inflammation"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An acute inflammatory process affecting the brain parenchyma. Causes include viral infections and less frequently bacterial infections, toxins, and immune-mediated processes."
      },
      "child_count": 21,
      "reference_id": "MONDO:0019956"
    }
  ],
  "children": [
    {
      "id": 19216,
      "label": "steroid-responsive encephalopathy associated with autoimmune thyroiditis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19722,
        20055
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0008570",
          "MEDGEN:98280",
          "MESH:C535841",
          "Orphanet:83601",
          "UMLS:C0393639"
        ],
        "synonyms": [
          "steroid-responsive encephalopathy associated with thyroid disease",
          "SREAT",
          "Hashimoto encephalitis",
          "Hashimoto's encephalitis",
          "Hashimoto's encephalopathy"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT) is a rare, acquired, neurological disease characterized by encephalopathy associated with elevated antithyroid antibodies, in the absence of other causes. Clinical presentation varies from minor cognitive impairment to status epilepticus and coma, and frequently includes seizures, confusion, speech disorder, memory impairment, ataxia and psychiatric manifestations."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019385"
    },
    {
      "id": 25135,
      "label": "autoimmune limbic encephalitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16388,
        20055
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0022492",
          "MEDGEN:419645",
          "Orphanet:623615",
          "UMLS:C2930824",
          "icd11.foundation:1254443511"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A rare autoimmune encephalitis involving the mesial temporal lobes and clinically characterized by subacute onset (i. e. rapid progression of less than three months) of short-term memory deficits, seizures or psychiatric symptoms, such as behavioral changes, anxiety, depression, and psychosis. Further diagnostic criteria are bilateral abnormalities restricted to the mesial temporal lobes in brain MRI, cerebrospinal fluid pleocytosis and/or epileptic or slow-wave activity involving the temporal lobes in EEG, and reasonable exclusion of alternative causes. Paraneoplastic or non-paraneoplastic antibodies against neuronal antigens may be found in serum and/or cerebrospinal fluid."
      },
      "child_count": 0,
      "reference_id": "MONDO:0850097"
    }
  ],
  "roots": [
    {
      "id": 2996,
      "label": "autoimmune disorder of central nervous system"
    },
    {
      "id": 19673,
      "label": "encephalitis"
    }
  ]
}