{
  "id": 20070,
  "label": "human papillomavirus-related penile squamous cell carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0020656",
  "properties": {
    "xrefs": [
      "GARD:0025200",
      "MEDGEN:235178",
      "NCIT:C27682",
      "UMLS:C1334056"
    ],
    "synonyms": [
      "HPV-related penile squamous cell carcinoma",
      "human papilloma virus related penile squamous cell carcinoma",
      "human papilloma virus-related penile squamous cell carcinoma",
      "human papillomavirus-related penile squamous cell carcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      }
    ],
    "definition": "A squamous cell carcinoma that arises from the penis and is caused by human papillomavirus infection. Morphologic variants include basaloid carcinoma and warty carcinoma."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 18435,
      "label": "squamous cell carcinoma of penis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6823,
        7886
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5518",
          "GARD:0021639",
          "MEDGEN:116057",
          "NCIT:C7729",
          "ONCOTREE:PSCC",
          "Orphanet:398058",
          "SCTID:403468003",
          "UMLS:C0238348",
          "icd11.foundation:186592209"
        ],
        "synonyms": [
          "epidermoid carcinoma of penis",
          "epidermoid carcinoma of the penis",
          "epidermoid cell carcinoma of penis",
          "epidermoid cell carcinoma of the penis",
          "penile epidermoid carcinoma",
          "penile epidermoid cell carcinoma",
          "penile squamous car.(epidermoid)",
          "penile squamous carcinoma (epidermoid)",
          "penile squamous cell cancer",
          "penile squamous cell carcinoma",
          "penis squamous cell carcinoma",
          "squamous cell carcinoma of penis",
          "squamous cell carcinoma of the penis",
          "PSCC"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A squamous cell carcinoma arising from the penis. It occurs chiefly in the squamous epithelium of the glans, coronal sulcus, and foreskin. Etiologic factors include phimosis, lichen sclerosus, smoking, ultraviolet irradiation, history of warts or condylomas, and lack of circumcision. Human papilloma virus is present in a subset of penile squamous cell carcinomas. Patients may present with an exophytic or flat ulcerative mass in the glans or a large primary tumor with inguinal nodal and skin metastases. Morphologic variants include the basaloid carcinoma, warty (condylomatous) carcinoma, verrucous carcinoma, and sarcomatoid (spindle cell) carcinoma. (WHO, 2004)"
      },
      "child_count": 10,
      "reference_id": "MONDO:0018352"
    },
    {
      "id": 20071,
      "label": "human papillomavirus-related squamous cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6823,
        17658
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025201",
          "MEDGEN:272726",
          "NCIT:C27683",
          "UMLS:C1334057"
        ],
        "synonyms": [
          "HPV-related squamous cell carcinoma",
          "human papilloma virus related squamous cell carcinoma",
          "human papilloma virus-related squamous cell carcinoma",
          "human papillomavirus-related squamous cell carcinoma"
        ]
      },
      "child_count": 2,
      "reference_id": "MONDO:0020657"
    }
  ],
  "children": [
    {
      "id": 5924,
      "label": "basaloid carcinoma of the penis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5405,
        20070
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7047",
          "GARD:0023813",
          "MEDGEN:231418",
          "NCIT:C6980",
          "ONCOTREE:BPSCC",
          "UMLS:C1332462"
        ],
        "synonyms": [
          "basaloid carcinoma of penis",
          "basaloid carcinoma of the penis",
          "basaloid penile squamous cell carcinoma",
          "basaloid squamous cell carcinoma of penis",
          "basaloid squamous cell carcinoma of the penis",
          "penis basaloid squamous cell carcinoma",
          "squamous cell carcinoma of penis, basaloid type",
          "squamous cell carcinoma of the penis, basaloid type",
          "BPSCC",
          "penis basaloid carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "An aggressive, human papillomavirus-related squamous cell carcinoma that arises from the penis. It is characterized by the presence of nests of small malignant cells. The malignant cells tend to invade deeply into the adjacent tissues. Comedo-type necrosis is often present."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004089"
    },
    {
      "id": 20063,
      "label": "warty carcinoma of the penis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6241,
        20070
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025197",
          "MEDGEN:234997",
          "NCIT:C6981",
          "ONCOTREE:WPSCC",
          "UMLS:C1337009"
        ],
        "synonyms": [
          "condylomatous carcinoma of penis",
          "condylomatous carcinoma of the penis",
          "condylomatous penile squamous cell carcinoma",
          "condylomatous squamous cell carcinoma of penis",
          "condylomatous squamous cell carcinoma of the penis",
          "squamous cell carcinoma of penis, condylomatous type",
          "squamous cell carcinoma of penis, warty type",
          "squamous cell carcinoma of the penis, condylomatous type",
          "squamous cell carcinoma of the penis, warty type",
          "warty carcinoma of penis",
          "warty carcinoma of the penis",
          "warty penile squamous cell carcinoma",
          "warty squamous cell carcinoma of penis",
          "warty squamous cell carcinoma of the penis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A squamous cell carcinoma that arises from the penis. It is characterized by a papillary growth pattern, hyperkeratosis and parakeratosis. Koilocytotic atypia is present. Human papillomavirus types 16 and 6 have been identified in some cases."
      },
      "child_count": 0,
      "reference_id": "MONDO:0020649"
    }
  ],
  "roots": [
    {
      "id": 18435,
      "label": "squamous cell carcinoma of penis"
    },
    {
      "id": 20071,
      "label": "human papillomavirus-related squamous cell carcinoma"
    }
  ]
}