{
  "id": 20078,
  "label": "high grade malignant neoplasm",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0020665",
  "properties": {
    "xrefs": [
      "MEDGEN:234350",
      "NCIT:C36046",
      "UMLS:C1334017"
    ],
    "synonyms": [
      "high grade malignant neoplasm"
    ]
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 6733,
      "label": "cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6798
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050686",
          "DOID:0050687",
          "DOID:162",
          "ICD9:195.8",
          "ICD9:199",
          "ICD9:199.1",
          "ICDO:8000/3",
          "MEDGEN:14297",
          "NCIT:C9305",
          "ONCOTREE:MT",
          "SCTID:363346000",
          "UMLS:C0006826",
          "birnlex:406"
        ],
        "synonyms": [
          "CA",
          "cancer",
          "cell type cancer",
          "malignancy",
          "malignant growth",
          "malignant neoplasm",
          "malignant neoplasm (disease)",
          "malignant neoplastic disease",
          "malignant tumor",
          "malignant tumour",
          "neoplasm (disease), malignant",
          "neoplasm, malignant",
          "MT"
        ],
        "definition": "A tumor composed of atypical neoplastic, often pleomorphic cells that invade other tissues. Malignant neoplasms often metastasize to distant anatomic sites and may recur after excision. The most common malignant neoplasms are carcinomas (adenocarcinomas or squamous cell carcinomas), Hodgkin and non-Hodgkin lymphomas, leukemias, melanomas, and sarcomas."
      },
      "child_count": 33,
      "reference_id": "MONDO:0004992"
    }
  ],
  "children": [
    {
      "id": 6433,
      "label": "in situ carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6734,
        20078,
        20315
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8719",
          "ICD9:230-234",
          "ICD9:234.8",
          "ICD9:234.9",
          "ICDO:8010/2",
          "MEDGEN:763",
          "MESH:D002278",
          "NCIT:C2917",
          "SCTID:109355002",
          "UMLS:C0007099"
        ],
        "synonyms": [
          "CIS",
          "carcinoma in situ",
          "carcinoma, in situ, malignant",
          "epithelial tumor, in situ, malignant",
          "intraepithelial carcinoma",
          "non-invasive carcinoma",
          "stage 0 disease"
        ],
        "definition": "A malignant epithelial neoplasm which is confined to the epithelial layer without evidence of further tissue invasion."
      },
      "child_count": 63,
      "reference_id": "MONDO:0004647"
    },
    {
      "id": 20050,
      "label": "anaplastic meningioma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        20048,
        20049,
        20078,
        20501
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025191",
          "ICDO:9530/3",
          "MEDGEN:75478",
          "NCIT:C4051",
          "ONCOTREE:ANM",
          "UMLS:C0259785"
        ],
        "synonyms": [
          "anaplastic (malignant) meningioma",
          "anaplastic meningioma",
          "malignant meningioma",
          "meningioma, anaplastic, malignant",
          "meningioma, malignant"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A WHO grade III meningioma characterized by the presence of malignant morphologic features, including malignant cytology and a very high mitotic index (20 or more mitoses per ten high power fields)."
      },
      "child_count": 0,
      "reference_id": "MONDO:0020635"
    },
    {
      "id": 24071,
      "label": "malignant glioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4753,
        20078,
        20287
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3070",
          "GARD:0026148",
          "ICDO:9380/3",
          "MEDGEN:107826",
          "MedDRA:10018338",
          "NCIT:C4822",
          "UMLS:C0555198"
        ],
        "synonyms": [
          "glioma",
          "neuroglial tumor",
          "neuroglial tumour",
          "glial cell tumour",
          "glioma, malignant",
          "high grade glioma",
          "high-grade glioma",
          "malignant glial neoplasm",
          "malignant glial tumor",
          "malignant glial tumour",
          "malignant glioma",
          "malignant neuroglial neoplasm",
          "malignant neuroglial tumor",
          "malignant neuroglial tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A grade III or grade IV glioma arising from the central nervous system. This category includes glioblastoma, anaplastic astrocytoma, anaplastic ependymoma, anaplastic oligodendroglioma, and anaplastic oligoastrocytoma."
      },
      "child_count": 36,
      "reference_id": "MONDO:0100342"
    }
  ],
  "roots": [
    {
      "id": 6733,
      "label": "cancer"
    }
  ]
}