{
  "id": 20099,
  "label": "adult glioblastoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0020690",
  "properties": {
    "xrefs": [
      "GARD:0025213",
      "MEDGEN:124527",
      "NANDO:2200087",
      "NCIT:C9094",
      "UMLS:C0278878"
    ],
    "synonyms": [
      "glioblastoma",
      "adult glioblastoma",
      "adult glioblastoma multiforme",
      "grade IV adult astrocytic neoplasm",
      "grade IV adult astrocytic tumor",
      "grade IV adult astrocytic tumour"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ]
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 6136,
      "label": "adult infiltrating astrocytic neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4577
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7656",
          "GARD:0023933",
          "MEDGEN:79278",
          "NCIT:C8289",
          "UMLS:C0281329"
        ],
        "synonyms": [
          "adult infiltrating astrocytic neoplasm",
          "adult infiltrating astrocytic tumor",
          "adult infiltrating astrocytic tumour",
          "adult infiltrating astrocytoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 1,
      "reference_id": "MONDO:0004320"
    },
    {
      "id": 18320,
      "label": "glioblastoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        17144
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3068",
          "EFO:0000519",
          "GARD:0002491",
          "HP:0012174",
          "HP:0100843",
          "ICDO:9440/3",
          "MEDGEN:42228",
          "MESH:D005909",
          "MedDRA:10018336",
          "MedDRA:10018337",
          "NANDO:2200087",
          "NCIT:C3058",
          "NORD:1187",
          "ONCOTREE:GB",
          "ONCOTREE:GBM",
          "Orphanet:360",
          "SCTID:393563007",
          "UMLS:C0017636"
        ],
        "synonyms": [
          "GBM",
          "GBM (glioblastoma)",
          "WHO grade IV glioma",
          "glioblastoma",
          "glioblastoma (disease)",
          "glioblastoma multiforme",
          "glioblastoma multiforme (disease)",
          "grade IV astrocytic neoplasm",
          "grade IV astrocytic tumor",
          "grade IV astrocytic tumour",
          "grade IV astrocytoma",
          "spongioblastoma multiforme",
          "grade IV adult astrocytic tumor",
          "grade IV adult astrocytic tumour",
          "giant cell glioblastoma (histologic variant)",
          "gliosarcoma (histologic variant)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "The most malignant astrocytic tumor (WHO grade IV). It is composed of poorly differentiated neoplastic astrocytes and it is characterized by the presence of cellular polymorphism, nuclear atypia, brisk mitotic activity, vascular thrombosis, microvascular proliferation and necrosis. It typically affects adults and is preferentially located in the cerebral hemispheres. It may develop from diffuse astrocytoma WHO grade II or anaplastic astrocytoma (secondary glioblastoma, IDH-mutant), but more frequently, it manifests after a short clinical history de novo, without evidence of a less malignant precursor lesion (primary glioblastoma, IDH- wildtype). (Adapted from WHO)"
      },
      "child_count": 7,
      "reference_id": "MONDO:0018177"
    }
  ],
  "children": [
    {
      "id": 6176,
      "label": "adult spinal cord glioblastoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4608,
        20099
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7806",
          "GARD:0023957",
          "MEDGEN:107849",
          "NCIT:C27183",
          "SCTID:276829003",
          "UMLS:C0559185"
        ],
        "synonyms": [
          "adult spinal cord glioblastoma",
          "adult spinal cord glioblastoma multiforme"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A rare spinal tumor which is highly malignant and tends to be locally invasive of surrounding neural tissue. The tumor also tends to spread throughout the neuroaxis and is often rapidly progressive. Histologically the tumors are highly cellular with nuclear and cellular pleomorphism, endothelial proliferation, mitotic figures, and, often, necrosis. This tumor has a relatively poor prognosis. Clinical features may include pain followed by rapidly progressive neurologic deficits such as extremity weakness, sensory changes, spasticity, and incontinence. (From Innocenzi et al., Clin Neurol Neurosurg 1997 Feb;99(1):1-5)"
      },
      "child_count": 0,
      "reference_id": "MONDO:0004363"
    }
  ],
  "roots": [
    {
      "id": 6136,
      "label": "adult infiltrating astrocytic neoplasm"
    },
    {
      "id": 18320,
      "label": "glioblastoma"
    }
  ]
}