{
  "id": 20146,
  "label": "mixed phenotype acute leukemia",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0020743",
  "properties": {
    "xrefs": [
      "GARD:0017972",
      "MEDGEN:417342",
      "MedDRA:10067399",
      "NANDO:2200018",
      "NCIT:C82179",
      "Orphanet:530995",
      "UMLS:C2826025"
    ],
    "synonyms": [
      "MPAL",
      "mixed phenotype acute leukemia"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0003900",
        "name": "connective tissue disorder"
      },
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "An acute leukemia of ambiguous lineage. It is characterized by the presence of either separate populations of blasts of more than one lineage, or one population of blasts co-expressing markers of more than one lineage."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 19285,
      "label": "acute leukemia of ambiguous lineage",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        18806
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0008638",
          "MEDGEN:226983",
          "MedDRA:10067399",
          "NANDO:2200017",
          "NANDO:2200018",
          "NCIT:C7464",
          "Orphanet:86851",
          "SCTID:721308005",
          "UMLS:C1301357",
          "icd11.foundation:1062906118"
        ],
        "synonyms": [
          "acute leukaemia of indeterminate lineage",
          "acute leukemia of ambiguous lineage",
          "acute leukemia of indeterminate lineage",
          "hybrid acute leukaemia",
          "hybrid acute leukemia",
          "mixed lineage acute leukaemia",
          "mixed lineage acute leukemia",
          "ALL with myeloid markers",
          "AML with lymphoid markers",
          "BAL",
          "acute leukaemia of undetermined lineage",
          "acute leukemia of undetermined lineage",
          "biphenotypic acute leukaemia",
          "biphenotypic acute leukemia",
          "mixed phenotype acute leukaemia",
          "mixed phenotype acute leukemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "An acute leukemia in which the blasts lack sufficient evidence to classify as myeloid or lymphoid or they have morphologic and/or immunophenotypic characteristics of both myeloid and lymphoid cells. (WHO, 2001)"
      },
      "child_count": 3,
      "reference_id": "MONDO:0019460"
    }
  ],
  "children": [
    {
      "id": 19795,
      "label": "acute biphenotypic leukemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6710,
        18035,
        20146
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9953",
          "EFO:1000828",
          "GARD:0025156",
          "ICD9:207.80",
          "ICDO:9805/3",
          "MEDGEN:7318",
          "MESH:D015456",
          "MedDRA:10067399",
          "NCIT:C4673",
          "Orphanet:98837",
          "SCTID:278453007",
          "UMLS:C0023464"
        ],
        "synonyms": [
          "B- and T-cell mixed leukaemia",
          "B- and T-cell mixed leukemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "An acute leukemia of ambiguous lineage characterized by blasts which coexpress myeloid and T or B lineage antigens or concurrent B and T lineage antigens. (WHO, 2001)"
      },
      "child_count": 12,
      "reference_id": "MONDO:0020322"
    },
    {
      "id": 22874,
      "label": "mixed phenotype acute leukemia with t(9;22)(q34.1;q11.2)",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18103,
        20146
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0022354",
          "ICD10CM:C92.7",
          "MEDGEN:414807",
          "Orphanet:589534",
          "UMLS:C2826037"
        ],
        "synonyms": [
          "MPAL with t(9;22)(q34.1;q11.2); BCR-ABL1"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0035639"
    },
    {
      "id": 22875,
      "label": "mixed phenotype acute leukemia with t(v;11q23.3)",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18103,
        20146
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0022357",
          "ICD10CM:C92.6",
          "MEDGEN:443130",
          "NCIT:C82203",
          "Orphanet:589595",
          "UMLS:C2826048"
        ],
        "synonyms": [
          "MPAL with t(v;11q23.3); KMT2A rearranged",
          "MPAL with t(v;11q23.3); MLL rearranged"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0035642"
    }
  ],
  "roots": [
    {
      "id": 19285,
      "label": "acute leukemia of ambiguous lineage"
    }
  ]
}