{
  "id": 20199,
  "label": "demyelinating disease of central nervous system",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0020800",
  "properties": {
    "xrefs": [
      "ICD10CM:G35-G37",
      "ICD9:341.8",
      "ICD9:341.9",
      "MEDGEN:3719",
      "NCIT:C34526",
      "SCTID:6118003",
      "UMLS:C0011302"
    ],
    "synonyms": [
      "demyelinating CNS disease",
      "demyelinating disease central nervous system (CNS)",
      "demyelinating disease of central nervous system",
      "demyelinating disorder of central nervous system",
      "demyelinating disorders of the central nervous system"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "Any condition in which there is degeneration of the myelin sheath that covers the nerves of the central nervous system."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 4626,
      "label": "demyelinating disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7208,
        20383
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3213",
          "MEDGEN:4189",
          "MESH:D003711",
          "NCIT:C34527",
          "UMLS:C0011303"
        ],
        "synonyms": [
          "demyelinating disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A broad group of disorders that affect the myelin sheaths that cover the neurons. Myelin sheathes cover neuronal axons in the central and peripheral nervous system and function to increase traveling impulse speeds. Disruption of this sheath impairs neuronal transmission and can result in disorders such as multiple sclerosis and Guillain-Barre syndrome, among others."
      },
      "child_count": 16,
      "reference_id": "MONDO:0002562"
    }
  ],
  "children": [
    {
      "id": 6995,
      "label": "multiple sclerosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2996,
        7209,
        8166,
        20199
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2377",
          "ICD10CM:G35",
          "ICD10WHO:G35",
          "ICD9:340",
          "MEDGEN:10123",
          "MESH:D009103",
          "NANDO:1200023",
          "NANDO:2100250",
          "NANDO:2200904",
          "NCIT:C3243",
          "Orphanet:802",
          "SCTID:24700007",
          "UMLS:C0026769",
          "icd11.foundation:1298865187"
        ],
        "synonyms": [
          "generalised multiple sclerosis",
          "generalized multiple sclerosis",
          "insular sclerosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A progressive autoimmune disorder affecting the central nervous system resulting in demyelination. Patients develop physical and cognitive impairments that correspond with the affected nerve fibers."
      },
      "child_count": 16,
      "reference_id": "MONDO:0005301"
    },
    {
      "id": 29255,
      "label": "myelin oligodendrocyte glycoprotein antibody-associated disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20199,
        20399
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:1813985",
          "UMLS:C5554054"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A demyelinating disease of the central nervous system characterized by the presence of a demyelinating event (optic neuritis, myelitis, acute/multiphasic encephalomyelitis, cerebral or polyfocal deficits, brainstem or cerebellar deficits, and/or cerebral cortical encephalitis), a positive myelin oligodendrocyte glycorotein-IgG test, and exclusion of an alternative diagnosis like MS."
      },
      "child_count": 8,
      "reference_id": "MONDO:1040024"
    }
  ],
  "roots": [
    {
      "id": 4626,
      "label": "demyelinating disease"
    }
  ]
}