{
  "id": 20287,
  "label": "glioma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0021042",
  "properties": {
    "xrefs": [
      "EFO:0005543",
      "GARD:0006513",
      "MEDGEN:9030",
      "MESH:D005910",
      "NCIT:C3059",
      "Orphanet:182067",
      "SCTID:393564001",
      "UMLS:C0017638"
    ],
    "synonyms": [
      "glial neoplasm",
      "glial tumor",
      "glial tumour",
      "glioma",
      "neoplasm of neuroglia",
      "neoplasm of the neuroglia",
      "neuroglial neoplasm",
      "neuroglial tumor",
      "neuroglial tumour",
      "tumor of neuroglia",
      "tumor of the neuroglia",
      "tumour of neuroglia",
      "tumour of the neuroglia"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "A benign or malignant brain and spinal cord tumor that arises from glial cells (astrocytes, oligodendrocytes, ependymal cells). Tumors that arise from astrocytes are called astrocytic tumors or astrocytomas. Tumors that arise from oligodendrocytes are called oligodendroglial tumors. Tumors that arise from ependymal cells are called ependymomas."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 9,
  "parents": [
    {
      "id": 20418,
      "label": "neuroepithelial neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20456
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:60215",
          "MESH:D018302",
          "NCIT:C3787",
          "ONCOTREE:PRNET",
          "UMLS:C0206715"
        ],
        "synonyms": [
          "neoplasm of neuroepithelial tissue",
          "neoplasm of neuroepithelium",
          "neoplasm of the neuroepithelium",
          "neuroepithelial neoplasm",
          "neuroepithelial neoplasms",
          "neuroepithelial tissue neoplasm",
          "neuroepithelial tissue tumor",
          "neuroepithelial tissue tumour",
          "neuroepithelial tumor",
          "neuroepithelial tumors",
          "neuroepithelial tumour",
          "neuroepithelial tumours",
          "tumor of neuroepithelial tissue",
          "tumor of neuroepithelium",
          "tumor of the neuroepithelium",
          "tumour of neuroepithelial tissue",
          "tumour of neuroepithelium",
          "tumour of the neuroepithelium",
          "primary neuroepithelial tumor",
          "primary neuroepithelial tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A neoplasm of the nervous system that arises from the neuroepithelial tissues. Representative examples include astrocytic tumors, oligodendroglial tumors, ependymal tumors, and primitive neuroectodermal tumors."
      },
      "child_count": 6,
      "reference_id": "MONDO:0021193"
    }
  ],
  "children": [
    {
      "id": 4613,
      "label": "nerve sheath neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3627,
        20287
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3193",
          "GARD:0023161",
          "MEDGEN:64639",
          "MESH:D018317",
          "NCIT:C4972",
          "ONCOTREE:NST",
          "UMLS:C0206727"
        ],
        "synonyms": [
          "neoplasm of nerve sheath",
          "neoplasm of the nerve sheath",
          "nerve sheath neoplasm",
          "nerve sheath tumor",
          "tumor of nerve sheath",
          "tumour of nerve sheath"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A benign or malignant neoplasm arising from the perineural cells in the sheaths surrounding the nerves. Representative examples include neurofibroma, schwannoma, and malignant peripheral nerve sheath tumor."
      },
      "child_count": 12,
      "reference_id": "MONDO:0002547"
    },
    {
      "id": 5210,
      "label": "ependymal tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20287
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000027",
          "GARD:0016527",
          "MEDGEN:232459",
          "NCIT:C6770",
          "ONCOTREE:EPMT",
          "Orphanet:301",
          "UMLS:C1333407"
        ],
        "synonyms": [
          "ependymal neoplasm",
          "ependymal tumor",
          "ependymal tumors",
          "ependymal tumours",
          "ependymomal tumor",
          "ependymomal tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A group of neoplasms which arise from the ependymal lining of the cerebral ventricles and from the remnants of the central canal of the spinal cord. Ependymal tumors occur predominantly in children and young adults with varied morphological features and biological behavior. There are 4 types: ependymoma, anaplastic ependymoma, myxopapillary ependymoma and subependymoma. (WHO)"
      },
      "child_count": 6,
      "reference_id": "MONDO:0003266"
    },
    {
      "id": 5211,
      "label": "mixed glioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20287,
        20288
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5076",
          "GARD:0023431",
          "ICDO:9382/3",
          "MEDGEN:75477",
          "NCIT:C3903",
          "SCTID:443937008",
          "UMLS:C0259783"
        ],
        "synonyms": [
          "glioma, mixed",
          "glioma, mixed, malignant",
          "mixed glial neoplasm",
          "mixed glial tumor",
          "mixed glial tumour",
          "mixed glioma",
          "mixed glioma (morphologic abnormality)",
          "mixed gliomas",
          "mixed neuroglial neoplasm",
          "mixed neuroglial tumor",
          "mixed neuroglial tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A tumor composed of two or more glial cell types (astrocytes, ependymal cells, and oligodendrocytes)."
      },
      "child_count": 6,
      "reference_id": "MONDO:0003268"
    },
    {
      "id": 16766,
      "label": "optic pathway glioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4014,
        17197,
        20287,
        20429
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0004107",
          "MEDGEN:162950",
          "NCIT:C8567",
          "Orphanet:2086",
          "UMLS:C0796418",
          "icd11.foundation:1000103370"
        ],
        "synonyms": [
          "glioma of optic tract",
          "glioma of the optic tract",
          "glioma of the visual pathway",
          "glioma of visual pathway",
          "optic pathway glioma",
          "optic tract glioma",
          "visual pathway glioma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "Optic pathway glioma (OPG) is a benign tumor that develop along the optic nerve (chiasm, tracts, and radiations) characterized by impairment or loss of vision and may be accompanied by diencephalic symptoms such as reduced growth and alteration in sleeping patterns. OPG are often linked to neurofibromatosis type 1 (NF1)."
      },
      "child_count": 8,
      "reference_id": "MONDO:0016167"
    },
    {
      "id": 17168,
      "label": "astroblastoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20287
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7305",
          "GARD:0010635",
          "ICDO:9430/3",
          "MEDGEN:90811",
          "NCIT:C4324",
          "ONCOTREE:ASTB",
          "Orphanet:251679",
          "UMLS:C0334587",
          "icd11.foundation:2011571705",
          "icd11.foundation:96344074"
        ],
        "synonyms": [
          "astroblastoma",
          "astroblastoma (morphologic abnormality)",
          "AstB",
          "cerebral astroblastoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Astroblastoma is a very rare glial neoplasm of the central nervous system, most often with an intra-axial peripheral supratentorial location in one hemisphere of the frontal or parietal lobes and usually presenting in infants and young adults with symptoms of vomiting, loss of consciousness, epileptic seizures and headaches."
      },
      "child_count": 1,
      "reference_id": "MONDO:0016707"
    },
    {
      "id": 20692,
      "label": "astrocytic tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20287
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3069",
          "GARD:0012928",
          "MedDRA:10003571",
          "NCIT:C6958",
          "Orphanet:94"
        ],
        "synonyms": [
          "astrocytic neoplasm",
          "astrocytic tumor",
          "astrocytoma, no ICD-O subtype",
          "astroglioma",
          "astrocytoma",
          "astrocytoma of cerebrum"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A glial tumor of the brain or spinal cord showing astrocytic differentiation. It includes the following clinicopathological entities: pilocytic astrocytoma, diffuse astrocytoma, anaplastic astrocytoma, pleomorphic xanthoastrocytoma, subependymal giant cell astrocytoma, and glioblastoma."
      },
      "child_count": 8,
      "reference_id": "MONDO:0021636"
    },
    {
      "id": 20693,
      "label": "low grade glioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20287
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060101",
          "DOID:0080829",
          "GARD:0025343",
          "MEDGEN:744283",
          "NCIT:C132067",
          "UMLS:C1997217"
        ],
        "synonyms": [
          "benign glioma",
          "glioma, benign",
          "low grade glioma",
          "low-grade glioma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A grade I or grade II glioma arising from the central nervous system. This category includes pilocytic astrocytoma, diffuse astrocytoma, subependymal giant cell astrocytoma, ependymoma, oligodendroglioma, oligoastrocytoma, and angiocentric glioma."
      },
      "child_count": 6,
      "reference_id": "MONDO:0021637"
    },
    {
      "id": 24071,
      "label": "malignant glioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4753,
        20078,
        20287
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3070",
          "GARD:0026148",
          "ICDO:9380/3",
          "MEDGEN:107826",
          "MedDRA:10018338",
          "NCIT:C4822",
          "UMLS:C0555198"
        ],
        "synonyms": [
          "glioma",
          "neuroglial tumor",
          "neuroglial tumour",
          "glial cell tumour",
          "glioma, malignant",
          "high grade glioma",
          "high-grade glioma",
          "malignant glial neoplasm",
          "malignant glial tumor",
          "malignant glial tumour",
          "malignant glioma",
          "malignant neuroglial neoplasm",
          "malignant neuroglial tumor",
          "malignant neuroglial tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A grade III or grade IV glioma arising from the central nervous system. This category includes glioblastoma, anaplastic astrocytoma, anaplastic ependymoma, anaplastic oligodendroglioma, and anaplastic oligoastrocytoma."
      },
      "child_count": 36,
      "reference_id": "MONDO:0100342"
    },
    {
      "id": 25601,
      "label": "diffuse glioma, H3 G34 mutant",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        20287
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080880",
          "GARD:0026786"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A histone mutated tumor that has material basis in mutations in codon 34 of the H3 histone family 3A protein."
      },
      "child_count": 0,
      "reference_id": "MONDO:0957197"
    }
  ],
  "roots": [
    {
      "id": 20418,
      "label": "neuroepithelial neoplasm"
    }
  ]
}