{
  "id": 20309,
  "label": "ovarian neoplasm",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0021068",
  "properties": {
    "xrefs": [
      "EFO:0003893",
      "ICD9:239.5",
      "MEDGEN:181539",
      "NCIT:C4984",
      "SCTID:123843001",
      "UMLS:C0919267"
    ],
    "synonyms": [
      "neoplasm of ovary",
      "neoplasm of the ovary",
      "ovarian neoplasm",
      "ovarian tumor",
      "ovarian tumors",
      "ovarian tumour",
      "ovarian tumours",
      "ovary neoplasm",
      "ovary neoplasm (disease)",
      "ovary tumor",
      "ovary tumour",
      "tumor of ovary",
      "tumor of the ovary",
      "tumour of ovary",
      "tumour of the ovary"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A benign, borderline, or malignant neoplasm involving the ovary."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 8,
  "parents": [
    {
      "id": 7207,
      "label": "ovarian disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4375,
        4379
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1100",
          "EFO:0005771",
          "MEDGEN:892314",
          "MESH:D010049",
          "NCIT:C26841",
          "SCTID:5552004",
          "UMLS:C4021818"
        ],
        "synonyms": [
          "disease of ovary",
          "disease or disorder of ovary",
          "disorder of ovary",
          "ovarian disease",
          "ovarian disorder",
          "ovary disease",
          "ovary disease or disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A disease involving the ovary."
      },
      "child_count": 22,
      "reference_id": "MONDO:0005558"
    },
    {
      "id": 20384,
      "label": "female reproductive system neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4379,
        7638
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:9004",
          "MESH:D005833",
          "NCIT:C3053",
          "UMLS:C0017416"
        ],
        "synonyms": [
          "female reproductive organ neoplasm (disease)",
          "female reproductive organ tumor",
          "female reproductive organ tumour",
          "female reproductive system neoplasm",
          "female reproductive system neoplasm (disease)",
          "female reproductive system tumor",
          "female reproductive system tumour",
          "gynecologic neoplasm",
          "gynecologic tumor",
          "gynecologic tumour",
          "neoplasm of female reproductive organ",
          "neoplasm of female reproductive system",
          "neoplasm of the female reproductive system",
          "tumor of female reproductive system",
          "tumor of the female reproductive system",
          "tumour of female reproductive system",
          "tumour of the female reproductive system"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A benign, precancerous, or malignant neoplasm that affects the female reproductive system. Representative examples include uterine corpus leiomyoma, endocervical polyp, ovarian carcinoma, cervical carcinoma, and endometrial carcinoma."
      },
      "child_count": 22,
      "reference_id": "MONDO:0021148"
    }
  ],
  "children": [
    {
      "id": 2984,
      "label": "ovarian melanoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6911,
        20309
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050928",
          "MEDGEN:1790038",
          "NCIT:C178441",
          "UMLS:C4761026"
        ],
        "synonyms": [
          "metastatic melanoma of ovary",
          "ovary melanoma (disease)",
          "ovary metastatic melanoma",
          "melanoma (disease) of ovary"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A melanoma (disease) that involves the ovary."
      },
      "child_count": 0,
      "reference_id": "MONDO:0000543"
    },
    {
      "id": 3047,
      "label": "ovarian benign neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3029,
        20309
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060112",
          "EFO:1000116",
          "MEDGEN:14058",
          "NCIT:C2895",
          "SCTID:92260003",
          "UMLS:C0004997",
          "icd11.foundation:181365103"
        ],
        "synonyms": [
          "benign neoplasm of ovary",
          "benign neoplasm of the ovary",
          "benign ovarian neoplasm",
          "benign ovarian tumor",
          "benign ovarian tumour",
          "benign tumor of ovary",
          "benign tumor of the ovary",
          "benign tumour of ovary",
          "benign tumour of the ovary",
          "ovary benign neoplasm"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A non-metastasizing neoplasm that arises from the ovary. Representative examples include serous cystadenoma, mucinous cystadenoma, clear cell adenofibroma, benign Brenner tumor, thecoma, and fibroma."
      },
      "child_count": 30,
      "reference_id": "MONDO:0000646"
    },
    {
      "id": 4347,
      "label": "ovarian epithelial tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7265,
        20309
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2152",
          "ICD9:239.5",
          "MEDGEN:90969",
          "NCIT:C4381",
          "ONCOTREE:OVT",
          "SCTID:237057005",
          "UMLS:C0341823"
        ],
        "synonyms": [
          "epithelial neoplasm of ovary",
          "epithelial neoplasm of the ovary",
          "epithelial tumor of ovary",
          "epithelial tumor of the ovary",
          "epithelial tumour of ovary",
          "epithelial tumour of the ovary",
          "ovarian epithelial tumor",
          "ovarian surface epithelial-stromal tumor",
          "ovarian surface epithelial-stromal tumour",
          "ovarian surface-epithelial stromal neoplasm",
          "ovary epithelial neoplasm",
          "OVT",
          "ovary epithelial cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign, borderline, or malignant tumor that originates from the surface epithelium of the ovary. It is composed of epithelial cells and stroma. Representative examples of benign tumors include serous cystadenoma, mucinous cystadenoma, and benign Brenner tumor. Representative examples of borderline tumors include serous surface papillary tumor, mucinous adenofibroma, and borderline Brenner tumor. Representative examples of malignant tumors include serous adenocarcinoma, mucinous adenocarcinoma, endometrioid adenocarcinoma, and malignant Brenner tumor."
      },
      "child_count": 22,
      "reference_id": "MONDO:0002229"
    },
    {
      "id": 5151,
      "label": "rete ovarii neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20309
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4895",
          "MEDGEN:271118",
          "NCIT:C40016",
          "UMLS:C1514909"
        ],
        "synonyms": [
          "neoplasm of rete ovarii",
          "rete ovarii neoplasm (disease)",
          "rete ovarii tumor",
          "rete ovarii tumour",
          "tumor of rete ovarii",
          "tumour of rete ovarii"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign or malignant neoplasm that arises from the rete ovarii which is located in the ovarian hilus. It includes adenoma, cystadenoma, cystadenofibroma, and adenocarcinoma."
      },
      "child_count": 3,
      "reference_id": "MONDO:0003192"
    },
    {
      "id": 5252,
      "label": "ovarian endometrioid stromal and related neoplasms",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        20309,
        22972
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5169",
          "MEDGEN:926076",
          "NCIT:C40065",
          "UMLS:C4288544"
        ],
        "synonyms": [
          "endometrioid stromal and related neoplasms of ovary",
          "ovarian endometrioid stromal and related neoplasms",
          "ovary endometrioid stromal and related neoplasms",
          "ovarian endometrioid stromal sarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A category of rare neoplasms that arise from the ovary. It includes low grade endometrioid stromal sarcoma and undifferentiated sarcoma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003312"
    },
    {
      "id": 9481,
      "label": "ovarian cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3637,
        20309
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2394",
          "ICD10CM:C56",
          "ICD9:183.0",
          "MEDGEN:216027",
          "MESH:D010051",
          "NCIT:C7431",
          "OMIM:167000",
          "Orphanet:213500",
          "SCTID:363443007",
          "UMLS:C1140680",
          "icd11.foundation:685124533"
        ],
        "synonyms": [
          "ovarian neoplasm",
          "ovary neoplasm",
          "tumor of the ovary",
          "tumour of the ovary",
          "cancer of ovary",
          "cancer of the ovary",
          "malignant neoplasm of ovary",
          "malignant neoplasm of the ovary",
          "malignant ovarian neoplasm",
          "malignant ovarian tumor",
          "malignant ovarian tumour",
          "malignant ovary neoplasm",
          "malignant tumor of ovary",
          "malignant tumor of the ovary",
          "malignant tumour of ovary",
          "malignant tumour of the ovary",
          "ovarian cancer",
          "ovarian cancer, somatic",
          "ovarian malignant tumor",
          "ovarian malignant tumour",
          "ovary cancer",
          "ovarian cancer, epithelial",
          "primary ovarian cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A primary or metastatic malignant neoplasm involving the ovary. Most primary malignant ovarian neoplasms are either carcinomas (serous, mucinous, or endometrioid adenocarcinomas) or malignant germ cell tumors. Metastatic malignant neoplasms to the ovary include carcinomas, lymphomas, and melanomas."
      },
      "child_count": 22,
      "reference_id": "MONDO:0008170"
    },
    {
      "id": 12476,
      "label": "ovarian germ cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6773,
        20309
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2156",
          "EFO:1000419",
          "GARD:0024792",
          "ICD9:239.5",
          "MEDGEN:65958",
          "NCIT:C3873",
          "OMIM:603737",
          "ONCOTREE:OGCT",
          "SCTID:237059008",
          "UMLS:C0238324"
        ],
        "synonyms": [
          "germ cell neoplasm of ovary",
          "germ cell neoplasm of the ovary",
          "germ cell tumor of ovary",
          "germ cell tumor of the ovary",
          "germ cell tumour of ovary",
          "germ cell tumour of the ovary",
          "ovarian germ cell neoplasm",
          "ovarian germ cell tumor",
          "ovary germ cell tumor",
          "ovary germ cell tumour",
          "ovarian germ cell cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A neoplasm that arises from the ovary and originates from germ cells. Representative examples include teratoma, embryonal carcinoma, yolk sac tumor, and dysgerminoma."
      },
      "child_count": 8,
      "reference_id": "MONDO:0011366"
    },
    {
      "id": 20709,
      "label": "ovarian sex cord-stromal tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7639,
        20309
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080369",
          "GARD:0012285",
          "MEDGEN:154644",
          "NCIT:C4862",
          "ONCOTREE:SCST",
          "UMLS:C0600113"
        ],
        "synonyms": [
          "Sex cord-stromal neoplasm of ovary",
          "Sex cord-stromal neoplasm of the ovary",
          "Sex cord-stromal tumor of ovary",
          "Sex cord-stromal tumor of the ovary",
          "Sex cord-stromal tumour of ovary",
          "Sex cord-stromal tumour of the ovary",
          "ovarian Sex cord-stromal neoplasm",
          "ovarian Sex cord-stromal tumor",
          "ovarian Sex cord-stromal tumour",
          "ovary sex cord-stromal tumor",
          "ovary sex cord-stromal tumour",
          "sex cord-stromal tumor of ovary",
          "sex cord-stromal tumour of ovary",
          "ovarian sex cord tumor with annular tubules",
          "ovarian sex cord tumour with annular tubules",
          "sex cord stromal tumor",
          "sex cord stromal tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign or malignant neoplasm that arises from the ovary and is composed of granulosa cells, Sertoli cells, Leydig cells, theca cells, and fibroblasts. Representative examples include thecoma, fibroma, Sertoli cell tumor, and granulosa cell tumor."
      },
      "child_count": 12,
      "reference_id": "MONDO:0021657"
    }
  ],
  "roots": [
    {
      "id": 7207,
      "label": "ovarian disorder"
    },
    {
      "id": 20384,
      "label": "female reproductive system neoplasm"
    }
  ]
}