{
  "id": 20310,
  "label": "malignant endocrine neoplasm",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0021069",
  "properties": {
    "xrefs": [
      "DOID:170",
      "ICD9:194.9",
      "MEDGEN:56319",
      "MESH:D004701",
      "NCIT:C3575",
      "UMLS:C0153658"
    ],
    "synonyms": [
      "endocrine neoplasm",
      "Endocrine tumour",
      "cancer of endocrine gland",
      "endocrine cancer",
      "endocrine gland cancer",
      "endocrine neoplasm, malignant",
      "malignant endocrine gland neoplasm",
      "malignant endocrine gland tumor",
      "malignant endocrine gland tumour",
      "malignant endocrine neoplasm",
      "malignant endocrine tumor",
      "malignant endocrine tumour",
      "malignant neoplasm of endocrine gland",
      "malignant neoplasm of the endocrine gland",
      "malignant tumor of endocrine gland",
      "malignant tumor of the endocrine gland",
      "malignant tumour of the endocrine gland"
    ],
    "categories": [
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A malignant neoplasm affecting the endocrine glands. Representative examples include thyroid gland carcinoma, parathyroid gland carcinoma, pituitary gland carcinoma, and adrenal cortex carcinoma."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 16,
  "parents": [
    {
      "id": 4223,
      "label": "endocrine gland neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6798,
        6875
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0003769",
          "ICD9:239.7",
          "MEDGEN:4044",
          "NCIT:C3010",
          "SCTID:387922007",
          "UMLS:C0014132"
        ],
        "synonyms": [
          "endocrine gland neoplasm (disease)",
          "endocrine gland tumor",
          "endocrine gland tumour",
          "endocrine neoplasm",
          "endocrine system neoplasm",
          "endocrine system tumor",
          "endocrine system tumour",
          "endocrine tumor",
          "endocrine tumour",
          "neoplasm of endocrine gland",
          "tumor of endocrine gland",
          "tumour of endocrine gland",
          "malignant endocrine tumor",
          "malignant endocrine tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign or malignant neoplasm arising from the epithelial cells of an endocrine organ. Representative examples include pituitary gland adenoma, pituitary gland carcinoma, thyroid gland carcinoma, carcinoid tumor, and neuroendocrine carcinoma."
      },
      "child_count": 28,
      "reference_id": "MONDO:0002082"
    },
    {
      "id": 6733,
      "label": "cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6798
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050686",
          "DOID:0050687",
          "DOID:162",
          "ICD9:195.8",
          "ICD9:199",
          "ICD9:199.1",
          "ICDO:8000/3",
          "MEDGEN:14297",
          "NCIT:C9305",
          "ONCOTREE:MT",
          "SCTID:363346000",
          "UMLS:C0006826",
          "birnlex:406"
        ],
        "synonyms": [
          "CA",
          "cancer",
          "cell type cancer",
          "malignancy",
          "malignant growth",
          "malignant neoplasm",
          "malignant neoplasm (disease)",
          "malignant neoplastic disease",
          "malignant tumor",
          "malignant tumour",
          "neoplasm (disease), malignant",
          "neoplasm, malignant",
          "MT"
        ],
        "definition": "A tumor composed of atypical neoplastic, often pleomorphic cells that invade other tissues. Malignant neoplasms often metastasize to distant anatomic sites and may recur after excision. The most common malignant neoplasms are carcinomas (adenocarcinomas or squamous cell carcinomas), Hodgkin and non-Hodgkin lymphomas, leukemias, melanomas, and sarcomas."
      },
      "child_count": 33,
      "reference_id": "MONDO:0004992"
    }
  ],
  "children": [
    {
      "id": 4245,
      "label": "thyroid cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16048,
        20310
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1781",
          "ICD10CM:C73",
          "ICD9:193",
          "MEDGEN:2869",
          "NANDO:2200074",
          "NCIT:C7510",
          "SCTID:363478007",
          "UMLS:C0007115",
          "icd11.foundation:447433352"
        ],
        "synonyms": [
          "neoplasm of thyroid gland",
          "thyroid gland neoplasm",
          "cancer of thyroid gland",
          "malignant neoplasm of the thyroid",
          "malignant neoplasm of the thyroid gland",
          "malignant neoplasm of thyroid",
          "malignant neoplasm of thyroid gland",
          "malignant thyroid gland neoplasm",
          "malignant thyroid gland tumor",
          "malignant thyroid gland tumour",
          "malignant thyroid neoplasm",
          "malignant thyroid tumor",
          "malignant thyroid tumour",
          "malignant tumor of the thyroid",
          "malignant tumor of the thyroid gland",
          "malignant tumor of thyroid",
          "malignant tumor of thyroid gland",
          "malignant tumour of the thyroid",
          "malignant tumour of the thyroid gland",
          "malignant tumour of thyroid",
          "malignant tumour of thyroid gland",
          "thyroid gland cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant neoplasm involving the thyroid gland"
      },
      "child_count": 6,
      "reference_id": "MONDO:0002108"
    },
    {
      "id": 4246,
      "label": "pituitary cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4265,
        4279,
        5646,
        17888,
        20310
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1785",
          "EFO:0005578",
          "GARD:0023064",
          "ICD10CM:C75.1",
          "MEDGEN:96922",
          "NCIT:C4769",
          "SCTID:363482009",
          "UMLS:C0496842",
          "icd11.foundation:1130461249"
        ],
        "synonyms": [
          "pituitary gland neoplasm",
          "pituitary neoplasm",
          "cancer of pituitary gland",
          "malignant neoplasm of pituitary",
          "malignant neoplasm of pituitary gland",
          "malignant neoplasm of the pituitary",
          "malignant neoplasm of the pituitary gland",
          "malignant pituitary gland neoplasm",
          "malignant pituitary gland tumor",
          "malignant pituitary gland tumour",
          "malignant pituitary neoplasm",
          "malignant pituitary tumor",
          "malignant pituitary tumour",
          "malignant tumor of pituitary",
          "malignant tumor of pituitary gland",
          "malignant tumor of the pituitary",
          "malignant tumor of the pituitary gland",
          "malignant tumour of pituitary",
          "malignant tumour of pituitary gland",
          "malignant tumour of the pituitary",
          "malignant tumour of the pituitary gland",
          "pituitary cancer",
          "pituitary gland cancer",
          "pituitary neoplasms, malignant",
          "pituitary tumor, malignant"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A primary or metastatic malignant neoplasm affecting the pituitary gland. Representative examples include functioning or non-functioning carcinomas arising from the anterior lobe of the pituitary gland, chordomas, chondrosarcomas, and metastatic carcinomas from the breast, lung, and gastrointestinal tract."
      },
      "child_count": 20,
      "reference_id": "MONDO:0002109"
    },
    {
      "id": 4255,
      "label": "neuroendocrine carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6734,
        19314,
        20310
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1800",
          "GARD:0023067",
          "ICDO:8246/3",
          "MEDGEN:104919",
          "MESH:D018278",
          "NCIT:C3773",
          "SCTID:253000007",
          "UMLS:C0206695"
        ],
        "synonyms": [
          "NEC",
          "neuroendocrine cancer",
          "neuroendocrine carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant neuroendocrine neoplasm composed of cells containing secretory granules that stain positive for NSE and chromogranin. The neoplastic cells are often round and form clusters or trabecular sheets. Representative examples are small cell carcinoma, large cell neuroendocrine carcinoma, and Merkel cell carcinoma."
      },
      "child_count": 36,
      "reference_id": "MONDO:0002120"
    },
    {
      "id": 4561,
      "label": "ovarian neuroendocrine neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        9481,
        19314,
        20310
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3002",
          "GARD:0023145",
          "MEDGEN:277459",
          "NCIT:C5237",
          "UMLS:C1335172"
        ],
        "synonyms": [
          "neuroendocrine neoplasm of ovary",
          "neuroendocrine neoplasm of the ovary",
          "neuroendocrine tumour of ovary",
          "ovarian neuroendocrine neoplasm",
          "ovary NET",
          "ovary neuroendocrine neoplasm",
          "ovary neuroendocrine tumor",
          "ovary neuroendocrine tumor, well differentiated, low or intermediate grade",
          "ovary neuroendocrine tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An epithelial neoplasm with neuroendocrine differentiation that arises from the ovary. It includes carcinoid tumor, small cell carcinoma pulmonary type, and large cell neuroendocrine carcinoma."
      },
      "child_count": 6,
      "reference_id": "MONDO:0002481"
    },
    {
      "id": 4646,
      "label": "thymus cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3028,
        6916,
        20310
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3277",
          "GARD:0023177",
          "ICD10CM:C37",
          "ICD9:164.0",
          "MEDGEN:155883",
          "NCIT:C4962",
          "SCTID:363434003",
          "UMLS:C0751552",
          "icd11.foundation:1718833206"
        ],
        "synonyms": [
          "thymic neoplasm",
          "thymic tumor",
          "thymic tumour",
          "Thymus cancer",
          "cancer of Thymus",
          "cancer of the Thymus",
          "cancer of thymus",
          "malignant Thymus neoplasm",
          "malignant Thymus tumor",
          "malignant Thymus tumour",
          "malignant neoplasm of Thymus",
          "malignant neoplasm of the Thymus",
          "malignant neoplasm of thymus",
          "malignant thymus neoplasm",
          "malignant tumor of Thymus",
          "malignant tumor of the Thymus",
          "malignant tumour of Thymus",
          "malignant tumour of the Thymus",
          "thymus cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A primary or metastatic malignant neoplasm involving the thymus. This category includes malignant thymomas, thymic lymphomas, primary thymic carcinomas, and metastatic carcinomas from other anatomic sites."
      },
      "child_count": 6,
      "reference_id": "MONDO:0002586"
    },
    {
      "id": 4735,
      "label": "liver cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4587,
        20310,
        21432
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3571",
          "GARD:0027613",
          "ICD9:155.0",
          "ICD9:155.2",
          "MEDGEN:87520",
          "NCIT:C34803",
          "SCTID:93870000",
          "UMLS:C0345904",
          "icd11.foundation:1605020868"
        ],
        "synonyms": [
          "cancer of liver",
          "hepatic cancer",
          "liver cancer",
          "malignant liver neoplasm",
          "malignant neoplasm of liver",
          "malignant neoplasm of liver, not specified as primary or secondary",
          "malignant neoplasm of liver, primary",
          "malignant tumour of liver",
          "primary liver cancer",
          "primary malignant liver neoplasm",
          "primary malignant neoplasm of liver",
          "primary cancer of liver",
          "primary tumor of the liver",
          "primary tumour of the liver"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An epithelial or non-epithelial malignant neoplasm that arises from the liver. Representative examples include hepatocellular carcinoma, intrahepatic cholangiocarcinoma, lymphoma, and sarcoma."
      },
      "child_count": 15,
      "reference_id": "MONDO:0002691"
    },
    {
      "id": 4843,
      "label": "adrenal gland cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7537,
        20310,
        20437
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3953",
          "GARD:0005751",
          "ICD10CM:C74",
          "ICD9:194.0",
          "ICD9:239.7",
          "MEDGEN:152909",
          "MESH:D000310",
          "NCIT:C9338",
          "SCTID:127021009",
          "UMLS:C0750887",
          "icd11.foundation:1766185236"
        ],
        "synonyms": [
          "adrenal neoplasm",
          "tumor of the adrenal gland",
          "tumour of the adrenal gland",
          "adrenal cancer",
          "adrenal gland cancer",
          "cancer of adrenal gland",
          "malignant adrenal gland neoplasm",
          "malignant adrenal gland tumor",
          "malignant adrenal gland tumour",
          "malignant adrenal neoplasm",
          "malignant adrenal tumor",
          "malignant adrenal tumour",
          "malignant neoplasm of adrenal gland",
          "malignant neoplasm of the adrenal gland",
          "malignant tumor of adrenal gland",
          "malignant tumor of the adrenal gland",
          "malignant tumour of adrenal gland",
          "malignant tumour of the adrenal gland"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant neoplasm involving the adrenal gland"
      },
      "child_count": 9,
      "reference_id": "MONDO:0002817"
    },
    {
      "id": 5194,
      "label": "pineal gland cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5646,
        20310,
        20442
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5032",
          "GARD:0027637",
          "ICD10CM:C75.3",
          "ICD9:194.4",
          "MEDGEN:102284",
          "NCIT:C3573",
          "SCTID:363483004",
          "UMLS:C0153655"
        ],
        "synonyms": [
          "neoplasm of the pineal region",
          "pineocytic tumor",
          "pineocytic tumour",
          "tumor of the pineal region",
          "tumour of the pineal region",
          "cancer of pineal body",
          "malignant neoplasm of pineal body",
          "malignant neoplasm of pineal gland",
          "malignant neoplasm of the pineal gland",
          "malignant pineal area neoplasm",
          "malignant pineal area tumor",
          "malignant pineal area tumour",
          "malignant pineal body neoplasm",
          "malignant pineal gland neoplasm",
          "malignant pineal gland tumor",
          "malignant pineal gland tumour",
          "malignant pineal region neoplasm",
          "malignant pineal region tumor",
          "malignant pineal region tumour",
          "malignant tumor of pineal gland",
          "malignant tumor of the pineal gland",
          "malignant tumour of pineal gland",
          "malignant tumour of the pineal gland",
          "pineal body cancer",
          "pinealoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Abnormal malignant growth of the cells that comprise the pineal parenchyma."
      },
      "child_count": 9,
      "reference_id": "MONDO:0003249"
    },
    {
      "id": 6436,
      "label": "malignant carotid body paraganglioma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4753,
        7266,
        20296,
        20310,
        20329
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8731",
          "GARD:0024080",
          "ICD10CM:C75.4",
          "ICD9:194.5",
          "MEDGEN:56318",
          "NCIT:C3574",
          "SCTID:447883002",
          "UMLS:C0153656"
        ],
        "synonyms": [
          "carotid body paraganglioma, malignant",
          "malignant carotid body paraganglioma",
          "malignant carotid body tumor (morphologic abnormality)",
          "malignant carotid body tumour (morphologic abnormality)",
          "carotid body cancer",
          "chemodectoma, malignant",
          "malignant carotid body neoplasm",
          "malignant carotid body tumor",
          "malignant carotid body tumour",
          "malignant neoplasm of carotid body",
          "malignant neoplasm of the carotid body",
          "malignant tumor of carotid body",
          "malignant tumor of the carotid body",
          "malignant tumour of carotid body",
          "malignant tumour of the carotid body"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A carotid body paraganglioma that metastasizes to other anatomic sites."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004650"
    },
    {
      "id": 7833,
      "label": "malignant jugulotympanic paraganglioma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4233,
        4265,
        4753,
        6420,
        20305,
        20310,
        20329,
        21452,
        23165
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0024363",
          "MEDGEN:87584",
          "NCIT:C4623",
          "UMLS:C0347856"
        ],
        "synonyms": [
          "cancer of jugular body",
          "jugular body cancer",
          "malignant glomus jugulare neoplasm",
          "malignant glomus jugulare tumor",
          "malignant glomus jugulare tumour",
          "malignant jugular body neoplasm",
          "malignant jugulotympanic paraganglioma",
          "malignant neoplasm of glomus jugulare",
          "malignant neoplasm of jugular body",
          "malignant neoplasm of the glomus jugulare",
          "malignant tumor of glomus jugulare",
          "malignant tumor of the glomus jugulare",
          "malignant tumour of glomus jugulare",
          "malignant tumour of the glomus jugulare"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A jugulotympanic paraganglioma that metastasizes to other anatomic sites."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006291"
    },
    {
      "id": 12245,
      "label": "pheochromocytoma/paraganglioma syndrome 2",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2903,
        2912,
        4753,
        7836,
        17682,
        20310,
        20329
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0061217",
          "GARD:0010544",
          "MEDGEN:357076",
          "MESH:C566646",
          "OMIM:601650",
          "UMLS:C1866552"
        ],
        "synonyms": [
          "SDHAF2 paraganglioma",
          "SDHAF2-related tumor predisposition",
          "paraganglioma caused by mutation in SDHAF2",
          "paragangliomas 2",
          "paragangliomas type 2",
          "pheochromocytoma/paraganglioma syndrome 2",
          "PGL2",
          "SDHAF2-related hereditary paraganglioma-pheochromocytoma syndrome (paragangliomas 2)",
          "glomus tumors, familial, 2"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An autosomal dominant tumor predisposition disorder caused by pathogenic variants in the SDHAF2 gene, characterized by an increased risk of paraganglioma, particularly head and neck paragangliomas."
      },
      "child_count": 0,
      "reference_id": "MONDO:0011121"
    },
    {
      "id": 14628,
      "label": "pheochromocytoma/paraganglioma syndrome 5",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2912,
        4753,
        7836,
        17682,
        20310,
        20329
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0061220",
          "GARD:0015763",
          "MEDGEN:481622",
          "OMIM:614165",
          "UMLS:C3279992"
        ],
        "synonyms": [
          "SDHA paraganglioma",
          "paraganglioma caused by mutation in SDHA",
          "paragangliomas 5",
          "paragangliomas type 5",
          "pheochromocytoma/paraganglioma syndrome 5",
          "PGL5"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Any paraganglioma in which the cause of the disease is a mutation in the SDHA gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0013602"
    },
    {
      "id": 16832,
      "label": "high-grade neuroendocrine carcinoma of the corpus uteri",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7594,
        20310,
        20702
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020482",
          "MEDGEN:1664315",
          "Orphanet:213731",
          "UMLS:C4751234"
        ],
        "synonyms": [
          "high-grade neuroendocrine carcinoma of the uterine corpus",
          "poorly differentiated neuroendocrine carcinoma of the corpus uteri",
          "poorly differentiated neuroendocrine carcinoma of the endometrium"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "High-grade neuroendocrine carcinoma of the corpus uteri is an extremely rare, aggressive, primary uterine neoplasm, originating from neuroendocrine cells scattered within the endometrium, characterized, macroscopically, by a bulky, frequently polypoid, mass with abundant necrosis located in the uterus and, histologically, by rosette-like and cord-like structures consisting of small, rounded cells with oval nuclei and scarce cytoplasm. Patients often present with dysfunctional uterine bleeding, pelvic or abdominal mass and, especially in later stages of the disease, abdominal pain. Symptomatic metastatic spread or symptoms related to a paraneoplastic syndrome, such as retinopathy, or Cushing syndrome due to ectopic ACTH production, may be associated."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016269"
    },
    {
      "id": 16833,
      "label": "low-grade neuroendocrine tumor of the corpus uteri",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7594,
        20310,
        20702
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020483",
          "MEDGEN:1672976",
          "NCIT:C126773",
          "Orphanet:213736",
          "UMLS:C5190779"
        ],
        "synonyms": [
          "low-grade neuroendocrine tumor of the uterine corpus",
          "low-grade neuroendocrine tumour of the uterine corpus",
          "well-differentiated neuroendocrine neoplasm of the endometrium",
          "well-differentiated neuroendocrine tumor of the corpus uteri",
          "well-differentiated neuroendocrine tumor of the endometrium",
          "well-differentiated neuroendocrine tumour of the corpus uteri",
          "well-differentiated neuroendocrine tumour of the endometrium"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Low-grade neuroendocrine tumor of the corpus uteri is an extremely rare uterine cancer typically characterized by a well demarcated, solid, frequently pedunculated tumor originating from neuroendocrine cells scattered within the endometrium, often associated with ectopic hormone production. Patients usually present with vaginal bleeding or discharge and a pelvic mass with a polypoid tumor sometimes protruding through the cervical canal. Symptoms related to ectopic hormone production (flushing, sweating, diarrhea, bronchospasm) may also develop."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016270"
    },
    {
      "id": 19985,
      "label": "maligant granulosa cell tumor of ovary",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18316,
        20310,
        21206
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019707",
          "MEDGEN:138043",
          "NCIT:C8403",
          "Orphanet:99915",
          "SCTID:254861002",
          "UMLS:C0346175",
          "icd11.foundation:148207042"
        ],
        "synonyms": [
          "adult ovarian granulosa cell tumor",
          "adult ovarian granulosa cell tumour",
          "cancer of granulosa cell",
          "granulosa cell cancer",
          "granulosa cell malignant tumor",
          "granulosa cell malignant tumour",
          "malignant granulosa cell neoplasm",
          "malignant granulosa cell neoplasm of ovary",
          "malignant granulosa cell neoplasm of the ovary",
          "malignant granulosa cell tumor of ovary",
          "malignant granulosa cell tumor of the ovary",
          "malignant granulosa cell tumour of ovary",
          "malignant granulosa cell tumour of the ovary",
          "malignant ovarian granulosa cell neoplasm",
          "malignant ovarian granulosa cell tumor",
          "malignant ovarian granulosa cell tumour",
          "ovarian granulosa cell tumor of adults",
          "ovarian granulosa cell tumour of adults",
          "GCT of the ovary",
          "GTCT",
          "Maligant granulosa cell tumor of the ovary",
          "Maligant granulosa cell tumour of the ovary",
          "adult granulosa cell tumor of the ovary",
          "adult granulosa cell tumour of the ovary",
          "granulosa theca cell tumor",
          "granulosa theca cell tumor of the ovary",
          "granulosa theca cell tumour",
          "granulosa theca cell tumour of the ovary"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An aggressive granulosa cell tumor that arises from the ovary and metastasizes to other anatomic sites."
      },
      "child_count": 0,
      "reference_id": "MONDO:0020541"
    },
    {
      "id": 20493,
      "label": "malignant tumor of parathyroid gland",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20310,
        20525
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD10CM:C75.0",
          "ICD9:194.1",
          "MEDGEN:102283",
          "NCIT:C9322",
          "ONCOTREE:PTH",
          "SCTID:363481002",
          "UMLS:C0153653"
        ],
        "synonyms": [
          "cancer of parathyroid gland",
          "malignant neoplasm of parathyroid",
          "malignant neoplasm of parathyroid gland",
          "malignant neoplasm of the parathyroid",
          "malignant neoplasm of the parathyroid gland",
          "malignant parathyroid gland neoplasm",
          "malignant parathyroid gland tumor",
          "malignant parathyroid gland tumour",
          "malignant parathyroid neoplasm",
          "malignant parathyroid tumor",
          "malignant parathyroid tumour",
          "malignant tumor of parathyroid",
          "malignant tumor of the parathyroid",
          "malignant tumor of the parathyroid gland",
          "malignant tumour of parathyroid",
          "malignant tumour of the parathyroid",
          "malignant tumour of the parathyroid gland",
          "parathyroid cancer",
          "parathyroid gland cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A cancer that involves the parathyroid gland."
      },
      "child_count": 2,
      "reference_id": "MONDO:0021311"
    }
  ],
  "roots": [
    {
      "id": 4223,
      "label": "endocrine gland neoplasm"
    },
    {
      "id": 6733,
      "label": "cancer"
    }
  ]
}