{
  "id": 20313,
  "label": "sympathetic paraganglioma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0021072",
  "properties": {
    "xrefs": [
      "GARD:0025286",
      "ICDO:8681/1",
      "MEDGEN:137758",
      "MESH:C531777",
      "NCIT:C4216",
      "SCTID:399343007",
      "UMLS:C0334415"
    ],
    "synonyms": [
      "Chromaffinoma",
      "chromaffin neoplasm",
      "chromaffin tumor",
      "chromaffin tumour",
      "paraganglioma of sympathetic nervous system",
      "sympathetic Paraganglionic neoplasm",
      "sympathetic nervous system paraganglioma",
      "sympathetic paraganglioma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A benign or malignant paraganglioma arising from the chromaffin cells of the paraganglia that are located along the sympathetic nerves. It includes extra-adrenal paragangliomas and paragangliomas that arise from the adrenal medulla. The latter are commonly referred to as pheochromocytomas. Representative examples of extra-adrenal sympathetic paragangliomas include the bladder, and superior and inferior paraaortic paragangliomas. Clinical signs are related to the secretion of catecholamines resulting in hypertension."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 2912,
      "label": "paraganglioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4464,
        19314,
        20691,
        24270
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050773",
          "EFO:1000453",
          "GARD:0022770",
          "ICD9:239.7",
          "ICDO:8680/1",
          "MEDGEN:10571",
          "MESH:D010235",
          "NCIT:C3308",
          "ONCOTREE:PGNG",
          "SCTID:127027008",
          "UMLS:C0030421"
        ],
        "synonyms": [
          "Paraganglionic neoplasm",
          "Paraganglionic tumor",
          "Paraganglionic tumour",
          "neoplasm of paraganglion",
          "neoplasm of the paraganglion",
          "paraganglioma",
          "paragangliomas",
          "paraganglion neoplasm",
          "paraganglion tumor",
          "paraganglion tumour",
          "tumor of paraganglion",
          "tumor of the paraganglion",
          "tumour of paraganglion",
          "tumour of the paraganglion",
          "chemodectoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign or malignant neoplasm arising from paraganglia located along the sympathetic or parasympathetic nerves. Infrequently, it may arise outside the usual distribution of the sympathetic and parasympathetic paraganglia. Tumors arising from the adrenal gland medulla are called pheochromocytomas. Morphologically, paragangliomas usually display a nesting (Zellballen) growth pattern. There are no reliable morphologic criteria to distinguish between benign and malignant paragangliomas. The only definitive indicator of malignancy is the presence of regional or distant metastases."
      },
      "child_count": 48,
      "reference_id": "MONDO:0000448"
    },
    {
      "id": 7265,
      "label": "epithelial neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6798
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0006858",
          "MEDGEN:277963",
          "MESH:D009375",
          "NCIT:C3709",
          "SCTID:118285006",
          "UMLS:C1368683"
        ],
        "synonyms": [
          "epithelial neoplasm",
          "epithelioma"
        ],
        "definition": "A benign or malignant neoplasm that arises from and is composed of epithelial cells. This category include adenomas, papillomas, and carcinomas."
      },
      "child_count": 24,
      "reference_id": "MONDO:0005626"
    },
    {
      "id": 23497,
      "label": "sympathetic nervous system disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3525
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:148206",
          "SCTID:50330009",
          "UMLS:C0750946"
        ],
        "synonyms": [
          "disease of sympathetic nervous system",
          "disease or disorder of sympathetic nervous system",
          "disorder of sympathetic nervous system",
          "sympathetic nervous system disease",
          "sympathetic nervous system disease or disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A disease or disorder that involves the sympathetic nervous system."
      },
      "child_count": 2,
      "reference_id": "MONDO:0044993"
    }
  ],
  "children": [
    {
      "id": 2989,
      "label": "extra-adrenal sympathetic paraganglioma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        20313
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050936",
          "EFO:0000489",
          "GARD:0022801",
          "MEDGEN:263453",
          "NCIT:C48576",
          "UMLS:C1257877"
        ],
        "synonyms": [
          "extra-adrenal Chromaffinoma",
          "extra-adrenal chromaffin neoplasm",
          "extra-adrenal pheochromocytoma",
          "extra-adrenal sympathetic Paraganglionic neoplasm",
          "extra-adrenal sympathetic paraganglioma",
          "extraadrenal pheochromocytoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign or malignant sympathetic paraganglioma arising from paraganglia outside the adrenal gland. Clinical symptoms are related to secretion of catecholamines. Representative examples include the superior and inferior paraaortic and bladder paragangliomas."
      },
      "child_count": 0,
      "reference_id": "MONDO:0000550"
    },
    {
      "id": 6716,
      "label": "adrenal gland pheochromocytoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20313,
        20446
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050892",
          "EFO:0000239",
          "GARD:0024140",
          "ICDO:8700/0",
          "MEDGEN:1636437",
          "NANDO:2200078",
          "NCIT:C3326",
          "UMLS:C4551683"
        ],
        "synonyms": [
          "pheochromocytoma",
          "Intraadrenal paraganglioma",
          "PCC",
          "adrenal gland Chromaffinoma",
          "adrenal gland chromaffin paraganglioma",
          "adrenal gland paraganglioma",
          "adrenal gland pheochromocytoma",
          "adrenal medullary paraganglioma",
          "adrenal medullary pheochromocytoma",
          "adrenal pheochromocytoma",
          "chromaffin paraganglioma of the adrenal gland",
          "pheochromocytoma (adrenal)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign or malignant neuroendocrine neoplasm of the sympathetic nervous system that secretes catecholamines. It arises from the chromaffin cells of the adrenal medulla. Clinical presentation includes headaches, palpitations, chest and abdominal pain, hypertension, fever, and tremor. Microscopically, a characteristic nesting (zellballen) growth pattern is usually seen. Other growth patterns including trabecular pattern may also be present."
      },
      "child_count": 6,
      "reference_id": "MONDO:0004974"
    }
  ],
  "roots": [
    {
      "id": 2912,
      "label": "paraganglioma"
    },
    {
      "id": 7265,
      "label": "epithelial neoplasm"
    },
    {
      "id": 23497,
      "label": "sympathetic nervous system disorder"
    }
  ]
}