{
  "id": 20314,
  "label": "paraneoplastic syndrome",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0021073",
  "properties": {
    "xrefs": [
      "MEDGEN:45320",
      "MESH:D010257",
      "NCIT:C3311",
      "SCTID:49783001",
      "UMLS:C0030472"
    ],
    "synonyms": [
      "paraneoplastic syndrome"
    ],
    "categories": [
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      }
    ],
    "definition": "A classification for rare disorders of diverse organ systems (endocrine, neuromuscular, gastrointestinal, renal, dermatologic, rheumatologic, hematologic) that are affected by substances secreted by a distant neoplasm but not by the action of the neoplasm itself metastasizing to that organ or tissue. Less than 1 % of neoplasms are associated with these syndromes. An immune-mediated response to neoplasm-elaborated proteins may be the cause of these syndromes. Additionally, their manifestation may signal the presence of an occult neoplasm, potentially at an earlier stage of disease thereby leading to a better clinical outcome. Constitutional signs may include fever, night sweats, anorexia and cachexia. Clinical course is usually progressive. Prognosis is variable depending on the effective treatment of the underlying neoplasm."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 8,
  "parents": [
    {
      "id": 4370,
      "label": "syndromic disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29379
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:225",
          "MEDGEN:11688",
          "MESH:D013577",
          "NCIT:C28193",
          "OGMS:0000086",
          "UMLS:C0039082"
        ],
        "synonyms": [
          "cluster, symptom",
          "clusters, symptom",
          "symptom cluster",
          "symptom clusters",
          "syndrome",
          "syndrome associated with disease or disorder",
          "syndromes",
          "syndromic disease",
          "syndromic disease or disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "A group of signs, symptoms, and clinicopathological characteristics that may or may not have a genetic basis and collectively define an abnormal condition."
      },
      "child_count": 1182,
      "reference_id": "MONDO:0002254"
    },
    {
      "id": 23540,
      "label": "cancer-related condition",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        23519
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:128925",
          "NCIT:C8278",
          "UMLS:C0280950"
        ],
        "synonyms": [
          "cancer related problem/condition",
          "cancer-related condition",
          "cancer-related problem or condition",
          "oncologic complications",
          "problem/condition, cancer related",
          "problem/condition, cancer-related"
        ],
        "definition": "A disorder either associated with an increased risk for malignant transformation (e.g., intraepithelial neoplasia, leukoplakia, dysplastic nevus, myelodysplastic syndrome) or that develops as a result of the presence of an existing malignant neoplasm (e.g., paraneoplastic syndrome)."
      },
      "child_count": 2,
      "reference_id": "MONDO:0045054"
    }
  ],
  "children": [
    {
      "id": 18348,
      "label": "paraneoplastic neurologic syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6799,
        20314
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0007326",
          "ICD9:331.89",
          "MEDGEN:155656",
          "MedDRA:10072106",
          "Orphanet:36388",
          "SCTID:192877007",
          "UMLS:C0751911"
        ],
        "synonyms": [
          "PCD",
          "PNS",
          "nervous system paraneoplastic syndrome",
          "paraneoplastic syndrome of nervous system",
          "paraneoplastic cerebellar degeneration"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A paraneoplastic syndrome that involves the nervous system."
      },
      "child_count": 14,
      "reference_id": "MONDO:0018215"
    },
    {
      "id": 24647,
      "label": "parneoplastic endocrine syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6875,
        20314
      ],
      "type_id": 0,
      "properties": {
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Paraneoplastic syndrome that involves the endocrine system."
      },
      "child_count": 4,
      "reference_id": "MONDO:0700252"
    },
    {
      "id": 24648,
      "label": "paraneoplastic hematological syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7217,
        20314
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0026398"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Paraneoplastic syndrome that involves the hematopoietic system."
      },
      "child_count": 4,
      "reference_id": "MONDO:0700253"
    },
    {
      "id": 24649,
      "label": "paraneoplastic gastrointestinal syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        20314
      ],
      "type_id": 0,
      "properties": {
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "Paraneoplastic syndrome that involves the digestive system."
      },
      "child_count": 0,
      "reference_id": "MONDO:0700254"
    },
    {
      "id": 24650,
      "label": "paraneoplastic renal syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4253,
        20314
      ],
      "type_id": 0,
      "properties": {
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "Paraneoplastic syndrome that involves the renal system."
      },
      "child_count": 2,
      "reference_id": "MONDO:0700255"
    },
    {
      "id": 24660,
      "label": "paraneoplastic rheumatic syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        20314
      ],
      "type_id": 0,
      "properties": {
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "Paraneoplastic syndrome that involves the joints, bones, muscles, and/or connective tissue."
      },
      "child_count": 0,
      "reference_id": "MONDO:0700265"
    },
    {
      "id": 24661,
      "label": "paraneoplastic cutaneous syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4198,
        20314
      ],
      "type_id": 0,
      "properties": {
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "Paraneoplastic syndrome that involves the integumental system."
      },
      "child_count": 2,
      "reference_id": "MONDO:0700266"
    },
    {
      "id": 26063,
      "label": "bilateral diffuse uveal melanocytic proliferation disease",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        20314
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027194",
          "MEDGEN:705031",
          "Orphanet:674968",
          "UMLS:C1282144"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0971131"
    }
  ],
  "roots": [
    {
      "id": 4370,
      "label": "syndromic disease"
    },
    {
      "id": 23540,
      "label": "cancer-related condition"
    }
  ]
}