{
  "id": 20322,
  "label": "anti-NMDA receptor encephalitis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0021081",
  "properties": {
    "xrefs": [
      "GARD:0020513",
      "MEDGEN:458943",
      "MESH:D060426",
      "NANDO:2201317",
      "NCIT:C94853",
      "Orphanet:217253",
      "SCTID:716684004",
      "UMLS:C2986717",
      "icd11.foundation:1568915618"
    ],
    "synonyms": [
      "anti-NMDA receptor encephalitis",
      "limbic encephalitis with N-methyl-D-aspartate receptor antibodies",
      "limbic encephalitis with NMDA receptor antibodies"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "An autoimmune acute encephalitis caused by antibodies against the glutamate NMDA receptor. It usually affects females and in the majority of cases it is associated with the presence of a tumor, most commonly an ovarian teratoma. The presence of a tumor in patients with this form of encephalitis implies that the latter is a paraneoplastic syndrome. It is manifested with psychiatric symptoms and epileptic seizures. It is a potentially lethal disorder; however, it is usually reversible with the prompt removal of the tumor."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 19673,
      "label": "encephalitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6880,
        7209,
        20092
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9588",
          "ICD10CM:A85",
          "ICD9:323.0",
          "ICD9:323.8",
          "ICD9:323.9",
          "MEDGEN:4027",
          "MESH:D004660",
          "MedDRA:10014581",
          "NCIT:C26760",
          "Orphanet:97275",
          "SCTID:45170000",
          "UMLS:C0014038"
        ],
        "synonyms": [
          "brain inflammation"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An acute inflammatory process affecting the brain parenchyma. Causes include viral infections and less frequently bacterial infections, toxins, and immune-mediated processes."
      },
      "child_count": 21,
      "reference_id": "MONDO:0019956"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 19673,
      "label": "encephalitis"
    }
  ]
}