{
  "id": 20387,
  "label": "dermis disorder",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0021154",
  "properties": {
    "xrefs": [
      "MEDGEN:1843083",
      "Orphanet:79381",
      "UMLS:C5681483"
    ],
    "synonyms": [
      "dermis disease",
      "dermis disease or disorder",
      "disease of dermis",
      "disease or disorder of dermis",
      "disorder of dermis",
      "other dermis disorder"
    ],
    "categories": [
      {
        "ref": "MONDO:0002051",
        "name": "integumentary system disorder"
      }
    ],
    "definition": "A disease that involves the dermis."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 28,
  "parents": [
    {
      "id": 6820,
      "label": "skin disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4198
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:37",
          "EFO:0000701",
          "ICD9:702",
          "ICD9:702.8",
          "ICD9:709.8",
          "MEDGEN:20777",
          "MESH:D012871",
          "NANDO:2100281",
          "NCIT:C3371",
          "SCTID:95320005",
          "UMLS:C0037274"
        ],
        "synonyms": [
          "cutaneous disorder",
          "disease of zone of skin",
          "disease or disorder of zone of skin",
          "disorder of skin",
          "disorder of zone of skin",
          "skin diseases and manifestations",
          "skin disorder",
          "zone of skin disease",
          "zone of skin disease or disorder",
          "dermatosis",
          "genodermatosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "Any deviation from the normal structure or function of the skin or subcutaneous tissue that is manifested by a characteristic set of symptoms and signs."
      },
      "child_count": 72,
      "reference_id": "MONDO:0005093"
    }
  ],
  "children": [
    {
      "id": 4409,
      "label": "dermis tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4599,
        20387
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2438",
          "GARD:0023112",
          "MEDGEN:91075",
          "NCIT:C4475",
          "UMLS:C0346041"
        ],
        "synonyms": [
          "dermal neoplasm",
          "dermal tumor",
          "dermal tumour",
          "dermis neoplasm",
          "dermis neoplasm (disease)",
          "dermis tumor",
          "neoplasm of dermis",
          "neoplasm of the dermis",
          "tumor of dermis",
          "tumor of the dermis",
          "tumour of the dermis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A benign, intermediate, or malignant neoplasm that arises from the dermis."
      },
      "child_count": 16,
      "reference_id": "MONDO:0002300"
    },
    {
      "id": 8062,
      "label": "necrobiosis lipoidica",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        20387
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3486",
          "EFO:1000738",
          "GARD:0013040",
          "MEDGEN:45021",
          "MESH:D009335",
          "NCIT:C34840",
          "Orphanet:542592",
          "SCTID:9418005",
          "UMLS:C0027538",
          "Wikipedia:Necrobiosis_lipoidica",
          "icd11.foundation:655608138"
        ],
        "synonyms": [
          "necrobiosis lipoidica",
          "necrobiosis lipoidica diabeticorum (formerly)"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "Necrobiosis lipoidica is a rare skin disorder of collagen degeneration. It is characterized by a rash that occurs on the lower legs. It is more common in women, and there are usually several spots. They are slightly raised shiny red-brown patches. The centers are often yellowish and may develop open sores that are slow to heal. Infections can occur but are uncommon. Some patients have itching, pain, or abnormal sensations. It usually occurs more often in people with diabetes, in people with a family history of diabetes or a tendency to get diabetes, but can occur in nondiabetic people. About 11% to 65% of patients with necrobiosis lipoidica also have diabetes, but the exact cause is still not known. Treatment is difficult. The disease is typically chronic with variable progression and scarring."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006583"
    },
    {
      "id": 8530,
      "label": "isolated anhidrosis with normal sweat glands",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        8014,
        19144,
        20387,
        23867
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060603",
          "GARD:0017843",
          "MEDGEN:1800259",
          "OMIM:106190",
          "Orphanet:468666",
          "UMLS:C5568836"
        ],
        "synonyms": [
          "Dann-Epstein-Sohar syndrome",
          "ITPR2 anhidrosis",
          "anhidrosis caused by mutation in ITPR2",
          "ANHD",
          "anhidrosis, isolated, with normal sweat glands",
          "isolated generalised anhidrosis with normal sweat glands",
          "isolated generalized anhidrosis with normal sweat glands"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "Any anhidrosis in which the cause of the disease is a mutation in the ITPR2 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0007118"
    },
    {
      "id": 8673,
      "label": "familial cutaneous collagenoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        20387
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0009799",
          "MEDGEN:96073",
          "MESH:C562925",
          "OMIM:115250",
          "Orphanet:53296",
          "SCTID:239139000",
          "UMLS:C0406817",
          "icd11.foundation:982220551"
        ],
        "synonyms": [
          "collagenoma, familial cutaneous"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "Familial cutaneous collagenoma is a connective tissue nevus characterized by multiple, flesh-colored asymptomatic nodules distributed symmetrically on the trunk and upper arms (mainly on the upper two-thirds of the back), manifesting around adolescence. The skin biopsy reveals an accumulation of collagen fibers with reduction in the number of elastic fibers. Cardiac anomalies may be observed. Familial cutaneous collagenoma follows an autosomal dominant mode of transmission."
      },
      "child_count": 0,
      "reference_id": "MONDO:0007271"
    },
    {
      "id": 8911,
      "label": "elastosis perforans serpiginosa",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        20387
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0010103",
          "ICD10CM:L87.2",
          "MEDGEN:65137",
          "MESH:C536202",
          "MedDRA:10014338",
          "OMIM:130100",
          "Orphanet:79148",
          "SCTID:49428008",
          "UMLS:C0221271",
          "icd11.foundation:1430012917"
        ],
        "synonyms": [
          "elastosis perforans serpiginosa",
          "Miescher elastoma",
          "elastoma Intrapapillare perforans verruciformis",
          "eps"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0007529"
    },
    {
      "id": 9464,
      "label": "progressive osseous heteroplasia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        20387,
        23867,
        25052
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0111535",
          "GARD:0000109",
          "MEDGEN:137714",
          "MESH:C562735",
          "MedDRA:10048902",
          "NORD:1618",
          "OMIM:166350",
          "Orphanet:2762",
          "SCTID:719271000",
          "UMLS:C0334041",
          "icd11.foundation:1107209347"
        ],
        "synonyms": [
          "POH",
          "familial ectopic ossification",
          "poh",
          "ectopic ossification familial type",
          "ectopic ossification, familial",
          "osseous heteroplasia, progressive",
          "osteoma cutis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A rare genetic bone disorder characterized clinically by progressive extraskeletal bone formation presenting in early life with cutaneous ossification, that progressively involves subcutaneous and then subsequently deep connective tissues, including muscle and fascia. POH overlaps with a number of related genetic disorders including Albright hereditary osteodystrophy, pseudohypoparathyroidism (see these terms), and primary osteoma cutis, that share the common features of superficial heterotopic ossification in association with inactivating mutations of GNAS gene (20q13.2-q13.3), coding for guanine nucleotide-binding proteins. POH can, however, be distinguished clinically by the deep and progressive nature of the heterotopic bone formation."
      },
      "child_count": 0,
      "reference_id": "MONDO:0008153"
    },
    {
      "id": 9643,
      "label": "antecubital pterygium syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        20387
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0004570",
          "MEDGEN:401231",
          "MESH:C566738",
          "OMIM:178200",
          "Orphanet:2987",
          "UMLS:C1867439"
        ],
        "synonyms": [
          "antecubital pterygium syndrome",
          "antecubital pterygium",
          "pterygium antecubital",
          "pterygium, antecubital"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0008339"
    },
    {
      "id": 10255,
      "label": "familial reactive perforating collagenosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        20387
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0013331",
          "MEDGEN:347504",
          "MESH:C565687",
          "OMIM:216700",
          "Orphanet:79147",
          "UMLS:C1857624",
          "icd11.foundation:563155724"
        ],
        "synonyms": [
          "RPC",
          "collagenosis, familial reactive perforating",
          "inherited reactive perforating collagenosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "Familial reactive perforating collagenosis is a very rare genetic skin disease characterized by transepidermal elimination of collagen fibers presenting as recurrent spontaneously involuting keratotic papules or nodules."
      },
      "child_count": 0,
      "reference_id": "MONDO:0009000"
    },
    {
      "id": 10342,
      "label": "dermochondrocorneal dystrophy",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4370,
        20387
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0001815",
          "ICD9:379.99",
          "MEDGEN:98151",
          "MESH:C535375",
          "OMIM:221800",
          "Orphanet:79149",
          "SCTID:254150007",
          "UMLS:C0432288",
          "icd11.foundation:1305138145"
        ],
        "synonyms": [
          "FranC'ois syndrome",
          "François syndrome",
          "dermochondrocorneal dystrophy",
          "DCCD",
          "Dermochondrocorneal dystrophy of François",
          "Francois syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "Dermochondrocorneal dystrophy is characterized by osteochondrodystrophy of the hands and feet, corneal dystrophy and the presence of skin nodules clustered around the metacarpophalangeal and interphalangeal joints, around the nose and ears and on the posterior surface of the elbow. Gingival lesions may also be present. It has been described in less than 20 patients. Transmission is autosomal recessive."
      },
      "child_count": 0,
      "reference_id": "MONDO:0009094"
    },
    {
      "id": 10754,
      "label": "lipoid proteinosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4594,
        20387,
        23867
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:14498",
          "GARD:0003268",
          "ICD9:272.8",
          "MEDGEN:6112",
          "MESH:D008065",
          "NANDO:2200608",
          "NCIT:C84829",
          "OMIM:247100",
          "Orphanet:530",
          "SCTID:38692000",
          "UMLS:C0023795",
          "icd11.foundation:326368380"
        ],
        "synonyms": [
          "Urbach-Wiethe disease",
          "hyalinosis cutis et mucosae",
          "lipid proteinosis",
          "lipoid proteinosis",
          "lipoproteinosis",
          "Urbach Wiethe disease",
          "hyalinosis cutis Et mucosae",
          "lipoid proteinosis of Urbach and Wiethe"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "Lipoid proteinosis (LP) is a rare genodermatosis characterized clinically by mucocutaneous lesions, hoarseness developing in early childhood and, at times, neurological complications."
      },
      "child_count": 0,
      "reference_id": "MONDO:0009530"
    },
    {
      "id": 16181,
      "label": "primary cutaneous amyloidosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        18960,
        20387
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050639",
          "GARD:0000132",
          "MEDGEN:120635",
          "MESH:C562642",
          "MedDRA:10011659",
          "NCIT:C199391",
          "Orphanet:137807",
          "SCTID:282834007",
          "UMLS:C0268397"
        ],
        "synonyms": [
          "primary localised cutaneous amyloidosis",
          "primary localized cutaneous amyloidosis",
          "PLCA",
          "familial primary localised cutaneous amyloidosis",
          "familial primary localized cutaneous amyloidosis",
          "amyloidosis IX",
          "amyloidosis familial cutaneous lichen",
          "amyloidosis, primary localised cutaneous",
          "amyloidosis, primary localized cutaneous",
          "lichen amyloidosis familial"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "Cutaneous amyloidosis refers to a variety of skin diseases characterized histologically by the extracellular accumulation of amyloid deposits in the dermis. Rare forms include lichen amyloidosus, X-linked reticulate pigmentary disorder, primary localized cutaneous nodular amyloidosis, and macular amyloidosis."
      },
      "child_count": 10,
      "reference_id": "MONDO:0015301"
    },
    {
      "id": 16226,
      "label": "linear atrophoderma of Moulin",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        20387
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019932",
          "MEDGEN:698076",
          "Orphanet:140933",
          "SCTID:403395007",
          "UMLS:C1274753",
          "icd11.foundation:1116101506"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "Linear atrophoderma of Moulin (LAM) is characterized by mildly atrophic and hyperpigmented band-like lesions that follow the lines of Blaschko on the trunk or limbs. Since its initial description in 1992, less than 30 cases have been reported in the literature. Onset occurs during childhood or adolescence and the disease is non-progressive. There is no prior inflammation or subsequent scleroderma. The etiology is unknown but as LAM follows the lines of Blaschko it has been suggested that the disease is caused by mosaicism of a predisposing gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0015371"
    },
    {
      "id": 16907,
      "label": "confetti-like macular atrophy",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        20387
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020544",
          "MEDGEN:1803272",
          "Orphanet:221142",
          "UMLS:C5687155"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0016376"
    },
    {
      "id": 16948,
      "label": "late-onset focal dermal elastosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        20387
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020578",
          "MEDGEN:1658281",
          "Orphanet:228227",
          "UMLS:C4751167"
        ],
        "synonyms": [
          "PXE-like late-onset focal dermal elastosis",
          "pseudoxanthoma-like late-onset focal dermal elastosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "Late-onset focal dermal elastosis is a rare, acquired, dermis elastic tissue disorder characterized by a pseudoxanthoma elasticum-like papular eruption consisting of multiple, slowly progressive, asymptomatic, 2-5 mm, white to yellowish, non-follicular papules (that tend to form cobblestone plaques) predominantly distributed over the neck, axillae and flexural areas, with no systemic involvement. Skin biopsy reveals a focal increase of normal-appearing elastic tissue in the reticular dermis with no calcium deposits."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016437"
    },
    {
      "id": 16949,
      "label": "linear focal dermal elastosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        20387
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020579",
          "MEDGEN:1666729",
          "Orphanet:228236",
          "UMLS:C4751166"
        ],
        "synonyms": [
          "Elastotic striae",
          "linear focal elastosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "Linear focal elastosis is a rare, acquired, dermis elastic tissue disorder characterized by asymptomatic, palpable, hypertrophic or atrophic, yellowish or red, indurated, horizontal, striae-like linear plaques distributed symmetrically across the mid and lower back. No systemic involvement has been described. Skin biopsy reveals a focal increase in abnormal elastic tissue with abundant, wavy, fragmented and aggregated, basophilic elastic fibers in the reticular dermis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016438"
    },
    {
      "id": 16950,
      "label": "elastoderma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        20387
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0012716",
          "ICD9:701.8",
          "MEDGEN:590504",
          "Orphanet:228240",
          "SCTID:238832003",
          "UMLS:C0406555",
          "icd11.foundation:1880397739"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "Elastoderma is a rare condition that affects the skin. People affected by elastoderma generally have increased laxity of skin covering a specific area of the body. Decreased recoil of the skin has also been reported. Although any part of the body can be affected, the skin of the neck and extremities (arms and legs, especially at the elbows and/or knees) are most commonly involved. The exact underlying cause is currently unknown; however, it generally occurs sporadically in people with no family history of the condition. There is no standard therapy available for elastoderma. Some cases have been treated with surgical excision (removal of affected skin), but hyperlaxity of skin often returns following the surgery."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016439"
    },
    {
      "id": 16953,
      "label": "elastoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        20387
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020582",
          "ICD9:215.9",
          "MEDGEN:473177",
          "Orphanet:228254",
          "SCTID:239140003",
          "UMLS:C0473583",
          "icd11.foundation:1464650282"
        ],
        "synonyms": [
          "Nevus elasticus",
          "Weidman juvenile elastoma",
          "juvenile elastoma without osteopoikilosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0016442"
    },
    {
      "id": 16954,
      "label": "papular elastorrhexis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        20387
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020583",
          "MEDGEN:1813032",
          "NCIT:C4707",
          "Orphanet:228264",
          "SCTID:239138008",
          "UMLS:C5680907",
          "icd11.foundation:1231672259"
        ],
        "synonyms": [
          "Nevus anelasticus",
          "disseminated nevus anelasticus",
          "eruptive collagenoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "An acquired form of collagenoma that appears in childhood. It is characterized by discrete, firm, skin-colored, and slightly elevated cutaneous papules, nodules or plaques that may be generalized, or found on the trunk and the extremities."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016443"
    },
    {
      "id": 16955,
      "label": "primary anetoderma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        20387
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020584",
          "MEDGEN:98029",
          "MESH:D057088",
          "Orphanet:228272",
          "SCTID:238829001",
          "UMLS:C0406550",
          "icd11.foundation:308286033"
        ],
        "synonyms": [
          "primary macular atrophy"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "Primary anetoderma is a rare skin disease characterized by loss of elastin tissue resulting in localized areas of flaccid skin in the absence of a secondary cause."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016444"
    },
    {
      "id": 16956,
      "label": "familial anetoderma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        20387
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020585",
          "MEDGEN:1387956",
          "Orphanet:228277",
          "SCTID:733467001",
          "UMLS:C4518793"
        ],
        "synonyms": [
          "hereditary anetoderma",
          "hereditary macular atrophy"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "Familial anetoderma is an extremely rare genetic skin disease characterized by loss of elastin tissue leading to localized areas of flaccid skin and a family history of the disorder."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016445"
    },
    {
      "id": 16958,
      "label": "white fibrous papulosis of the neck",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        20387
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020587",
          "MEDGEN:1647664",
          "Orphanet:228290",
          "UMLS:C4706484",
          "icd11.foundation:1989852752"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "White fibrous papulosis of the neck (WFPN) is a rare, acquired, dermal elastic tissue disorder characterized by multiple, 2-3 mm sized, non-confluent, asymptomatic, white or pale-colored, non-follicular, firm papular lesions occurring predominantly on the lateral or posterior aspects of the neck. Other, rarely reported sites include inferior axillae, central mid-back and upper sternal region."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016447"
    },
    {
      "id": 16960,
      "label": "mid-dermal elastolysis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        20387
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020589",
          "MEDGEN:1672488",
          "Orphanet:228299",
          "UMLS:C4728147",
          "icd11.foundation:1379952112"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0016449"
    },
    {
      "id": 18480,
      "label": "lichen myxedematosus",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4593,
        20387
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021709",
          "ICD9:701.8",
          "MEDGEN:1848864",
          "Orphanet:402007",
          "SCTID:111197009",
          "UMLS:C5848049"
        ],
        "synonyms": [
          "lichen myxoedematosus",
          "lichenoid myxedema",
          "papular mucinosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ]
      },
      "child_count": 6,
      "reference_id": "MONDO:0018432"
    },
    {
      "id": 18584,
      "label": "pseudoxanthoma elasticum-like skin manifestations with retinitis pigmentosa",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4370,
        20387
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021820",
          "MEDGEN:1810682",
          "Orphanet:436274",
          "UMLS:C5680045"
        ],
        "synonyms": [
          "PXE-like syndrome with retinitis pigmentosa"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0018577"
    },
    {
      "id": 18945,
      "label": "primary cutis verticis gyrata",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20387
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0001643",
          "ICD9:757.39",
          "MEDGEN:78095",
          "Orphanet:671",
          "SCTID:51603000",
          "UMLS:C0263417",
          "icd11.foundation:71926572"
        ],
        "synonyms": [
          "cutis verticis gyrata"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "Cutis verticis gyrata (CVG) is a progressive cutaneous disorder predominantly affecting males and characterized by hypertrophy and thickening of the skin of the scalp forming convoluted furrows with deep, tender, and cerebriform cutaneous folds. Hair is usually normal in the furrows and sparse on the folds. CG can be isolated (essential CVG) or associated with other abnormalities such as intellectual deficit, epilepsy, cataract, blindness, and deafness (non essential CVG)."
      },
      "child_count": 3,
      "reference_id": "MONDO:0019033"
    },
    {
      "id": 19143,
      "label": "mixed dermis disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20387
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:1842502",
          "Orphanet:79380",
          "UMLS:C5681484"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ]
      },
      "child_count": 6,
      "reference_id": "MONDO:0019294"
    },
    {
      "id": 20877,
      "label": "atrophoderma of Pierini and Pasini",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4370,
        20387
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0005866",
          "ICD10CM:L90.3",
          "MEDGEN:854615",
          "Orphanet:658810",
          "SCTID:711524008",
          "UMLS:C3887897"
        ],
        "synonyms": [
          "congenital atrophoderma of Pasini and Pierini",
          "idiopathic atrophoderma of Pasini and Pierini"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "Atrophoderma of Pierini and Pasini is thought to possibly represent a late stage of morphea a type of localized scleroderma. Signs and symptoms ofatrophoderma of Pierini and Pasini include multiple oval, darkened (hyperpigmented) plaques in which tissue under the skin breaks downso that there is a depression (dent) within the skin. Some findings suggest that atrophoderma of Pierini and Pasini may be associated with B burgdorferi, a bacteria that causesLyme disease, in some cases."
      },
      "child_count": 0,
      "reference_id": "MONDO:0022513"
    },
    {
      "id": 26282,
      "label": "annular erythema of infancy",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        20387
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "Orphanet:699057"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0979325"
    }
  ],
  "roots": [
    {
      "id": 6820,
      "label": "skin disorder"
    }
  ]
}