{
  "id": 20398,
  "label": "Paget disease",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0021165",
  "properties": {
    "xrefs": [
      "MEDGEN:277958",
      "NCIT:C7073",
      "UMLS:C1368019"
    ],
    "synonyms": [
      "Paget cell neoplasm",
      "Paget disease",
      "Paget's cell neoplasm",
      "Paget's disease"
    ],
    "definition": "A malignant neoplasm composed of large cells with large nuclei, prominent nucleoli, and abundant pale cytoplasm (Paget cells). Paget cell neoplasms include Paget disease of the nipple and extramammary Paget disease which may affect the vulva, penis, anus, skin and scrotum."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 5,
  "parents": [
    {
      "id": 6712,
      "label": "adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6734,
        21312
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "CSP:2000-0386",
          "DOID:299",
          "EFO:0000228",
          "ICDO:8140/3",
          "MEDGEN:122",
          "MESH:D000230",
          "NCIT:C2852",
          "ONCOTREE:ADNOS",
          "SCTID:443961001",
          "UMLS:C0001418"
        ],
        "synonyms": [
          "adenocarcinoma",
          "adenocarcinoma NOS (morphologic abnormality)",
          "adenocarcinoma, malignant",
          "adenocarcinoma, no subtype (morphologic abnormality)",
          "adenocarcinomas",
          "ADNOS"
        ],
        "definition": "A common cancer characterized by the presence of malignant glandular cells. Morphologically, adenocarcinomas are classified according to the growth pattern (e.g., papillary, alveolar) or according to the secreting product (e.g., mucinous, serous). Representative examples of adenocarcinoma are ductal and lobular breast carcinoma, lung adenocarcinoma, renal cell carcinoma, hepatocellular carcinoma (hepatoma), colon adenocarcinoma, and prostate adenocarcinoma."
      },
      "child_count": 128,
      "reference_id": "MONDO:0004970"
    }
  ],
  "children": [
    {
      "id": 4699,
      "label": "mammary Paget disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6729,
        20398
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3443",
          "ICDO:8540/3",
          "MEDGEN:18263",
          "MESH:D010144",
          "NCIT:C47857",
          "UMLS:C0030185"
        ],
        "synonyms": [
          "Paget disease of the breast",
          "Paget's disease of breast",
          "Paget's disease of the breast",
          "breast Paget disease",
          "mammary Paget disease",
          "mammary Paget's disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A malignant neoplasm in which there is infiltration of the skin overlying the breast by neoplastic large cells with abundant pale cytoplasm and large nuclei with prominent nucleoli (Paget cells). It is almost always associated with an intraductal or invasive ductal carcinoma of the breast. The clinical features include focal skin reddening, and eczema. Retraction of the nipple may sometimes occur."
      },
      "child_count": 2,
      "reference_id": "MONDO:0002648"
    },
    {
      "id": 4700,
      "label": "scrotum Paget disease",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4701,
        20398
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3444",
          "MEDGEN:65959",
          "NCIT:C7728",
          "UMLS:C0238330"
        ],
        "synonyms": [
          "Paget disease of the scrotum",
          "Paget's disease of scrotum",
          "Paget's disease of the scrotum",
          "scrotal Paget's disease",
          "scrotum Paget disease",
          "scrotum Paget's disease",
          "scrotum mammary Paget's disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A mammary Paget's disease that involves the scrotum."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002649"
    },
    {
      "id": 4706,
      "label": "cutaneous Paget disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4707,
        20398
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3450"
        ],
        "synonyms": [
          "cutaneous Paget's disease",
          "zone of skin Paget disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A skin carcinoma that is characterized by infiltration of the skin by neoplastic large cells with abundant pale cytoplasm and large nuclei with prominent nucleoli."
      },
      "child_count": 2,
      "reference_id": "MONDO:0002655"
    },
    {
      "id": 6094,
      "label": "osteosarcoma arising in bone Paget disease",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4505,
        4680,
        20398
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7542",
          "GARD:0023906",
          "ICDO:9184/3",
          "MEDGEN:569679",
          "NCIT:C6469",
          "UMLS:C0334546"
        ],
        "synonyms": [
          "Paget osteosarcoma",
          "Paget's osteosarcoma",
          "osteosarcoma arising in Paget disease of bone",
          "osteosarcoma arising in Paget's disease of bone",
          "osteosarcoma arising in bone Paget's disease",
          "osteosarcoma arising in osseous Paget's disease",
          "osteosarcoma arising in osteitis deformans"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A sarcomatous transformation of pre-existing Paget disease of the bone. Osteosarcomas arising from Paget disease of the bone are high grade lesions and usually have a poor prognosis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004275"
    },
    {
      "id": 9488,
      "label": "extramammary Paget disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20398
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000249",
          "GARD:0004192",
          "ICDO:8542/3",
          "MEDGEN:45280",
          "MESH:D010145",
          "MedDRA:10033366",
          "MedDRA:10068223",
          "NCIT:C3302",
          "OMIM:167300",
          "ONCOTREE:EMPD",
          "Orphanet:2800",
          "UMLS:C0030186",
          "icd11.foundation:1796624917"
        ],
        "synonyms": [
          "Extramammary Paget's disease",
          "Paget disease Extramammary",
          "Paget's disease of skin",
          "Paget's disease of the skin",
          "Paget's skin disease",
          "extramammary Paget disease",
          "EMPD",
          "Paget disease, EXTRAMAMMARY",
          "cutaneous Paget's disease"
        ],
        "definition": "A malignant neoplasm in which there is infiltration of the skin by neoplastic large cells with abundant pale cytoplasm and large nuclei with prominent nucleoli (Paget cells). It may affect the anus, penis, scrotum, and vulva."
      },
      "child_count": 3,
      "reference_id": "MONDO:0008177"
    }
  ],
  "roots": [
    {
      "id": 6712,
      "label": "adenocarcinoma"
    }
  ]
}