{
  "id": 20417,
  "label": "odontogenic neoplasm",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0021192",
  "properties": {
    "xrefs": [
      "GARD:0027878",
      "ICDO:9270/1",
      "MEDGEN:10426",
      "MESH:D009808",
      "NCIT:C3286",
      "UMLS:C0028880"
    ],
    "synonyms": [
      "calcareous tooth neoplasm",
      "calcareous tooth neoplasm (disease)",
      "calcareous tooth tumor",
      "calcareous tooth tumour",
      "neoplasm of calcareous tooth",
      "odontogenic neoplasm",
      "odontogenic tumor",
      "odontogenic tumour",
      "tumor of calcareous tooth",
      "tumour of calcareous tooth"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0006858",
        "name": "mouth disorder"
      }
    ],
    "definition": "A benign or malignant neoplasm arising from tooth-forming tissues. It occurs in the maxillofacial skeleton or the gingiva. Benign tumors are slow growing and are not associated with specific clinical symptoms. Pain is absent or slight. Malignant tumors are usually associated with rapid swelling and pain."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 7231,
      "label": "head and neck neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6798
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0005950",
          "ICD9:239.89",
          "MEDGEN:6728",
          "NCIT:C3077",
          "ONCOTREE:HEADNECK",
          "SCTID:255055008",
          "UMLS:C0018671"
        ],
        "synonyms": [
          "craniocervical region neoplasm",
          "craniocervical region neoplasm (disease)",
          "craniocervical region tumor",
          "craniocervical region tumour",
          "head and neck neoplasm",
          "head and neck neoplasm (excluding central nervous system)",
          "head and neck tumor",
          "head and neck tumour",
          "neoplasm of craniocervical region",
          "neoplasm of head and neck",
          "neoplasm of the head and neck",
          "tumor of craniocervical region",
          "tumor of head and neck",
          "tumor of the head and neck",
          "tumour of craniocervical region",
          "tumour of head and neck",
          "tumour of the head and neck"
        ],
        "definition": "A benign or malignant neoplasm that affects the anatomic structures of the head and neck region. Representative examples of benign neoplasms include salivary gland pleomorphic adenoma and nasal cavity papilloma. Representative examples of malignant neoplasms include oral cavity squamous cell carcinoma, laryngeal squamous cell carcinoma, and salivary gland carcinoma."
      },
      "child_count": 37,
      "reference_id": "MONDO:0005586"
    },
    {
      "id": 8422,
      "label": "tooth disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6893,
        8301
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1091",
          "EFO:1001216",
          "MEDGEN:11852",
          "MESH:D014076",
          "NCIT:C35077",
          "SCTID:234947003",
          "UMLS:C0040435"
        ],
        "synonyms": [
          "calcareous tooth disease",
          "calcareous tooth disease or disorder",
          "dental disorder",
          "disease of calcareous tooth",
          "disease or disorder of calcareous tooth",
          "disorder of calcareous tooth",
          "tooth disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ],
        "definition": "A disease involving the calcareous tooth."
      },
      "child_count": 22,
      "reference_id": "MONDO:0006999"
    },
    {
      "id": 20434,
      "label": "digestive system neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6798
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0008549",
          "MEDGEN:8398",
          "MESH:D005770",
          "NCIT:C3052",
          "UMLS:C0012243"
        ],
        "synonyms": [
          "GI neoplasm",
          "GI system neoplasm",
          "GI system tumor",
          "GI system tumour",
          "GI tumor",
          "GI tumour",
          "digestive neoplasm",
          "digestive system neoplasm (disease)",
          "digestive system tumor",
          "digestive system tumour",
          "digestive tumor",
          "digestive tumour",
          "gastrointestinal neoplasm",
          "gastrointestinal system neoplasm",
          "gastrointestinal system tumor",
          "gastrointestinal system tumour",
          "gastrointestinal tumor",
          "gastrointestinal tumour",
          "neoplasm of GI system",
          "neoplasm of digestive system",
          "neoplasm of gastrointestinal system",
          "neoplasm of the GI system",
          "neoplasm of the digestive system",
          "neoplasm of the gastrointestinal system",
          "tumor of GI system",
          "tumor of digestive system",
          "tumor of gastrointestinal system",
          "tumor of the GI system",
          "tumor of the digestive system",
          "tumor of the gastrointestinal system",
          "tumour of GI system",
          "tumour of digestive system",
          "tumour of gastrointestinal system",
          "tumour of the GI system",
          "tumour of the digestive system",
          "tumour of the gastrointestinal system"
        ],
        "definition": "A neoplasm (disease) that involves the digestive system."
      },
      "child_count": 23,
      "reference_id": "MONDO:0021223"
    }
  ],
  "children": [
    {
      "id": 7657,
      "label": "ameloblastic carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3041,
        4185,
        7738,
        20417
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000078",
          "GARD:0011855",
          "MEDGEN:231088",
          "NCIT:C7492",
          "NORD:763",
          "Orphanet:314422",
          "UMLS:C1314678"
        ],
        "synonyms": [
          "ameloblastic carcinoma",
          "odontoma, ameloblastic, malignant"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ],
        "definition": "A rare, cytologically malignant ameloblastoma that may metastasize."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006079"
    },
    {
      "id": 18018,
      "label": "ameloblastoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3040,
        20417,
        22952
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050894",
          "GARD:0005747",
          "ICDO:9310/0",
          "MEDGEN:1457",
          "MESH:D000564",
          "MedDRA:10066796",
          "NCIT:C4313",
          "NORD:764",
          "Orphanet:314419",
          "SCTID:285311001",
          "UMLS:C0002448"
        ],
        "synonyms": [
          "ameloblastoma",
          "ameloblastoma of jaw",
          "Adenoameloblastoma",
          "adamantinoma",
          "adenomatoid odontogenic tumor",
          "adenomatoid odontogenic tumour",
          "aot"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ],
        "definition": "The most common odontogenic tumor, arising from the epithelial component of the embryonic tooth and usually affecting the molar-ramus region of the mandible or maxilla. Although most ameloblastomas are morphologically and clinically benign, they may cause extensive local destruction, recur, or metastasize."
      },
      "child_count": 12,
      "reference_id": "MONDO:0017795"
    },
    {
      "id": 18644,
      "label": "Keratocystic odontogenic tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        20417
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021870",
          "MEDGEN:313330",
          "NCIT:C54302",
          "Orphanet:447777",
          "SCTID:713277006",
          "UMLS:C1708604"
        ],
        "synonyms": [
          "KTOC",
          "odontogenic Keratocyst",
          "odontogenic keratocystoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ],
        "definition": "An intraosseous odontogenic neoplasm that usually arises from the mandible. It is characterized by the presence of a single or multiple cysts lined with parakeratinized stratified squamous epithelium. The neoplastic lesions may be solitary or multiple. It has the potential for aggressive behavior, local destruction, and recurrence."
      },
      "child_count": 0,
      "reference_id": "MONDO:0018648"
    },
    {
      "id": 20810,
      "label": "calcifying epithelial odontogenic tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4599,
        20417
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027904",
          "ICDO:9340/0",
          "MEDGEN:87266",
          "MESH:C537961",
          "NCIT:C54301",
          "UMLS:C0334574"
        ],
        "synonyms": [
          "Pindborg tumor",
          "Pindborg tumour",
          "calcifying epithelial odontogenic tumor",
          "CEOT"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ],
        "definition": "A slow growing, locally invasive neoplasm arising from tooth-forming tissues. It most often grows intraosseously in the mandible and less frequently in the maxilla. In a minority of cases it grows extraosseously in the gingiva. It is characterized by the presence of a fibrous stroma, epithelial cells with abundant eosinophilic cytoplasm, and amyloid material which is often calcified. Small tumors may be successfully treated with enucleation. Local resection is usually required for larger tumors. Recurrences have been reported in a minority of cases."
      },
      "child_count": 0,
      "reference_id": "MONDO:0022057"
    }
  ],
  "roots": [
    {
      "id": 7231,
      "label": "head and neck neoplasm"
    },
    {
      "id": 8422,
      "label": "tooth disorder"
    },
    {
      "id": 20434,
      "label": "digestive system neoplasm"
    }
  ]
}