{
  "id": 20431,
  "label": "eye neoplasm",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0021220",
  "properties": {
    "xrefs": [
      "EFO:0003824",
      "ICD10CM:C69-C72",
      "MEDGEN:5095",
      "NCIT:C3030",
      "ONCOTREE:EYE",
      "UMLS:C0015414"
    ],
    "synonyms": [
      "eye neoplasm (disease)",
      "eye tumor",
      "eye tumour",
      "eyeball of camera-type eye neoplasm",
      "eyeball of camera-type eye tumor",
      "eyeball of camera-type eye tumour",
      "neoplasm of eye",
      "neoplasm of eyeball of camera-type eye",
      "neoplasm of the eye",
      "ocular neoplasm",
      "ocular tumor",
      "ocular tumour",
      "tumor of eye",
      "tumor of eyeball of camera-type eye",
      "tumor of the eye",
      "tumour of eye",
      "tumour of eyeball of camera-type eye",
      "tumour of the eye"
    ],
    "categories": [
      {
        "ref": "MONDO:0002022",
        "name": "disorder of orbital region"
      },
      {
        "ref": "MONDO:0024458",
        "name": "disorder of visual system"
      }
    ],
    "definition": "A neoplasm (disease) that involves the eye."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 13,
  "parents": [
    {
      "id": 7019,
      "label": "eye disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4171,
        21415
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1242",
          "DOID:5614",
          "EFO:0003966",
          "ICD9:360",
          "ICD9:360.29",
          "ICD9:360.89",
          "ICD9:360.9",
          "ICD9:379.8",
          "ICD9:379.90",
          "MEDGEN:5092",
          "MESH:D005128",
          "NCIT:C26767",
          "SCTID:371405004",
          "UMLS:C0015397"
        ],
        "synonyms": [
          "disease of eye",
          "disease of eyeball of camera-type eye",
          "disease or disorder of eyeball of camera-type eye",
          "disorder of eye",
          "disorder of eyeball of camera-type eye",
          "eye disease",
          "eye disorder",
          "eyeball of camera-type eye disease",
          "eyeball of camera-type eye disease or disorder",
          "globe disease",
          "disease of eyeball",
          "disorder of eye proper",
          "disorder of eyeball",
          "disorder of globe"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A non-neoplastic or neoplastic disorder that affects the eye. Representative examples include conjunctivitis, glaucoma, cataract, conjunctival squamous cell carcinoma, uveal melanoma, and retinoblastoma."
      },
      "child_count": 240,
      "reference_id": "MONDO:0005328"
    },
    {
      "id": 7231,
      "label": "head and neck neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6798
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0005950",
          "ICD9:239.89",
          "MEDGEN:6728",
          "NCIT:C3077",
          "ONCOTREE:HEADNECK",
          "SCTID:255055008",
          "UMLS:C0018671"
        ],
        "synonyms": [
          "craniocervical region neoplasm",
          "craniocervical region neoplasm (disease)",
          "craniocervical region tumor",
          "craniocervical region tumour",
          "head and neck neoplasm",
          "head and neck neoplasm (excluding central nervous system)",
          "head and neck tumor",
          "head and neck tumour",
          "neoplasm of craniocervical region",
          "neoplasm of head and neck",
          "neoplasm of the head and neck",
          "tumor of craniocervical region",
          "tumor of head and neck",
          "tumor of the head and neck",
          "tumour of craniocervical region",
          "tumour of head and neck",
          "tumour of the head and neck"
        ],
        "definition": "A benign or malignant neoplasm that affects the anatomic structures of the head and neck region. Representative examples of benign neoplasms include salivary gland pleomorphic adenoma and nasal cavity papilloma. Representative examples of malignant neoplasms include oral cavity squamous cell carcinoma, laryngeal squamous cell carcinoma, and salivary gland carcinoma."
      },
      "child_count": 37,
      "reference_id": "MONDO:0005586"
    }
  ],
  "children": [
    {
      "id": 4352,
      "label": "eyelid neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4599,
        5315,
        20431
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2173",
          "EFO:1000934",
          "MEDGEN:41939",
          "MESH:D005142",
          "NCIT:C3031",
          "Orphanet:98580",
          "SCTID:278697001",
          "UMLS:C0015424"
        ],
        "synonyms": [
          "eyelid neoplasm",
          "eyelid neoplasm (disease)",
          "eyelid tumor",
          "eyelid tumour",
          "neoplasm of eyelid",
          "neoplasm of the eyelid",
          "palpebral tumor",
          "palpebral tumour",
          "tumor of eyelid",
          "tumor of the eyelid",
          "tumour of eyelid",
          "tumour of the eyelid"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A benign or malignant neoplasm that affects the eyelid. Representative examples include hemangioma, nevus, and carcinoma."
      },
      "child_count": 9,
      "reference_id": "MONDO:0002235"
    },
    {
      "id": 4353,
      "label": "ocular cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3050,
        7266,
        20431
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2174",
          "ICD9:190.8",
          "ICD9:239.89",
          "MEDGEN:105418",
          "MESH:D005134",
          "NCIT:C4767",
          "SCTID:371486001",
          "UMLS:C0496836"
        ],
        "synonyms": [
          "eye neoplasm",
          "neoplasm of eye",
          "ocular tumor",
          "ocular tumour",
          "cancer of eye",
          "cancer of eyeball of camera-type eye",
          "cancer of the eye",
          "eye cancer",
          "eye neoplasm, malignant",
          "eyeball of camera-type eye cancer",
          "malignant eye neoplasm",
          "malignant eye tumor",
          "malignant eye tumour",
          "malignant eyeball of camera-type eye neoplasm",
          "malignant neoplasm of eye",
          "malignant neoplasm of eyeball of camera-type eye",
          "malignant neoplasm of the eye",
          "malignant ocular neoplasm",
          "malignant ocular tumor",
          "malignant ocular tumour",
          "malignant tumor of eye",
          "malignant tumor of the eye",
          "malignant tumour of eye",
          "malignant tumour of the eye",
          "neoplasm of eye proper"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A benign or malignant neoplasm affecting the structures of the eye."
      },
      "child_count": 30,
      "reference_id": "MONDO:0002236"
    },
    {
      "id": 9686,
      "label": "ring dermoid of cornea",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5714,
        20431
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0111548",
          "GARD:0009696",
          "MEDGEN:357922",
          "MESH:C535684",
          "OMIM:180550",
          "Orphanet:91481",
          "SCTID:723499000",
          "UMLS:C1867155",
          "icd11.foundation:271430543"
        ],
        "synonyms": [
          "Ring dermoid syndrome",
          "ring dermoid of cornea",
          "RDC",
          "RING dermoid of cornea",
          "bilateral, annular limbal dermoids with corneal and conjunctival extension"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "Ring dermoid of cornea is characterized by annular limbal dermoids (growths with a skin-like structure) with corneal and conjunctival extension. Less than 30 cases have been described. Transmission is autosomal dominant and mutations in the PITX2 gene have been suggested as a potential cause of the condition."
      },
      "child_count": 0,
      "reference_id": "MONDO:0008387"
    },
    {
      "id": 17432,
      "label": "intraocular medulloepithelioma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7212,
        20431
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020945",
          "MEDGEN:408140",
          "NCIT:C66806",
          "Orphanet:268139",
          "UMLS:C1883694"
        ],
        "synonyms": [
          "intraocular medulloepithelioma",
          "orbital medulloepithelioma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "Intraocular medulloepithelioma is a rare eye tumor characterized by a white, gray or yellow-colored cystic mass that arises from the primitive neuroectodermal, nonpigmented epithelium of the ciliary body, or occasionally from the optic nerve, optic disk, retina or iris. Typically it has a benign clinical course with good prognosis and generally presents with childhood onset of poor vision and pain, glaucoma, and/or cataract. Leukocoria, exotropia, exophthalmos, strabismus, epiphora, change in eye color, hyphema, and raised intraocular pressure are also remarkable manifestations."
      },
      "child_count": 0,
      "reference_id": "MONDO:0017050"
    },
    {
      "id": 18609,
      "label": "combined hamartoma of the retina and retinal pigment epithelium",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        20431
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021843",
          "MEDGEN:396281",
          "NCIT:C174548",
          "Orphanet:440727",
          "UMLS:C1862062"
        ],
        "synonyms": [
          "CHR-RPE",
          "combined hamartoma of the retina and RPE"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0018607"
    },
    {
      "id": 18816,
      "label": "orbital leiomyoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        20431
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018845",
          "MEDGEN:930669",
          "Orphanet:52994",
          "SCTID:719045009",
          "UMLS:C4305000",
          "icd11.foundation:614302400"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "Orbital leiomyoma is a rare benign smooth muscle tumor arising from the walls of orbital vessels characterized by its slow growth and well encapsulated nature. It is usually located in an extraconal position, commonly manifesting with painless proptosis. The tumor is composed of spindle cells arranged in a fibrous stroma rich in dilated sinusoidal capillaries. The nuclei of tumor cells are oval with blunted ends and there are no mitotic figures. Orbital leiomyoma when excised has excellent prognosis for vision and life. One case of orbital leiomyosarcoma that possibly represents sarcomatous change in an orbital leiomyoma following radiation treatment has been reported."
      },
      "child_count": 0,
      "reference_id": "MONDO:0018885"
    },
    {
      "id": 19761,
      "label": "conjunctival tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7730,
        20431
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:3208",
          "NCIT:C2961",
          "Orphanet:98616",
          "UMLS:C0009761"
        ],
        "synonyms": [
          "conjunctiva neoplasm",
          "conjunctiva neoplasm (disease)",
          "conjunctiva tumor",
          "conjunctiva tumour",
          "conjunctival neoplasm",
          "conjunctival neoplasms",
          "conjunctival tumor",
          "neoplasm of conjunctiva",
          "neoplasm of the conjunctiva",
          "tumor of conjunctiva",
          "tumor of the conjunctiva",
          "tumour of conjunctiva",
          "tumour of the conjunctiva"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A benign or malignant neoplasm that affects the conjunctiva. Representative examples include papilloma, squamous cell carcinoma, and melanoma."
      },
      "child_count": 6,
      "reference_id": "MONDO:0020204"
    },
    {
      "id": 20433,
      "label": "lacrimal gland neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20431,
        21539
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:83280",
          "NCIT:C4360",
          "UMLS:C0339124"
        ],
        "synonyms": [
          "lacrimal gland neoplasm (disease)",
          "lacrimal gland tumor",
          "lacrimal gland tumour",
          "neoplasm of lacrimal gland",
          "neoplasm of the lacrimal gland",
          "tumor of lacrimal gland",
          "tumor of the lacrimal gland",
          "tumour of lacrimal gland",
          "tumour of the lacrimal gland"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A neoplasm (disease) that involves the lacrimal gland."
      },
      "child_count": 4,
      "reference_id": "MONDO:0021222"
    },
    {
      "id": 20436,
      "label": "uvea neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4712,
        20431
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:52960",
          "NCIT:C3436",
          "UMLS:C0042162"
        ],
        "synonyms": [
          "neoplasm of the uvea",
          "neoplasm of uvea",
          "tumor of the uvea",
          "tumor of uvea",
          "tumour of the uvea",
          "tumour of uvea",
          "uvea neoplasm (disease)",
          "uvea tumor",
          "uvea tumour",
          "uveal neoplasm",
          "uveal tumor",
          "uveal tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A neoplasm (disease) that involves the uvea."
      },
      "child_count": 6,
      "reference_id": "MONDO:0021225"
    },
    {
      "id": 20441,
      "label": "retina neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6979,
        20431,
        20456
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000509",
          "MEDGEN:101180",
          "NCIT:C4800",
          "UMLS:C0524801"
        ],
        "synonyms": [
          "neoplasm of retina",
          "neoplasm of the retina",
          "retina neoplasm (disease)",
          "retina tumor",
          "retina tumour",
          "retinal neoplasm",
          "retinal tumor",
          "retinal tumour",
          "tumor of retina",
          "tumor of the retina",
          "tumour of retina",
          "tumour of the retina"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A neoplasm (disease) that involves the retina."
      },
      "child_count": 15,
      "reference_id": "MONDO:0021231"
    },
    {
      "id": 20447,
      "label": "cornea neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3211,
        20431
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:90940",
          "NCIT:C4361",
          "UMLS:C0339304"
        ],
        "synonyms": [
          "cornea neoplasm (disease)",
          "cornea tumor",
          "cornea tumour",
          "corneal neoplasm",
          "corneal tumor",
          "corneal tumour",
          "neoplasm of cornea",
          "neoplasm of the cornea",
          "tumor of cornea",
          "tumor of the cornea",
          "tumour of cornea",
          "tumour of the cornea"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A neoplasm (disease) that involves the cornea."
      },
      "child_count": 6,
      "reference_id": "MONDO:0021238"
    },
    {
      "id": 20576,
      "label": "benign neoplasm of eye",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3038,
        20431
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD9:224.0",
          "ICD9:224.8",
          "ICD9:224.9",
          "MEDGEN:401267",
          "NCIT:C4780",
          "SCTID:92097004",
          "UMLS:C1867616"
        ],
        "synonyms": [
          "benign eye neoplasm",
          "benign eye tumor",
          "benign eye tumour",
          "benign neoplasm of the eye",
          "benign ocular neoplasm",
          "benign ocular tumor",
          "benign ocular tumour",
          "benign tumor of eye",
          "benign tumor of the eye",
          "benign tumour of eye",
          "benign tumour of the eye",
          "eye benign neoplasm"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A benign neoplasm that involves the eye."
      },
      "child_count": 14,
      "reference_id": "MONDO:0021454"
    },
    {
      "id": 26024,
      "label": "ocular surface squamous neoplasia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4600,
        20431
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027162",
          "MEDGEN:1787978",
          "Orphanet:659744",
          "UMLS:C4761284"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0971056"
    }
  ],
  "roots": [
    {
      "id": 7019,
      "label": "eye disorder"
    },
    {
      "id": 7231,
      "label": "head and neck neoplasm"
    }
  ]
}