{
  "id": 20437,
  "label": "adrenal gland neoplasm",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0021227",
  "properties": {
    "xrefs": [
      "EFO:0003850",
      "GARD:0019765",
      "MEDGEN:1352",
      "NCIT:C2859",
      "ONCOTREE:ADRENAL_GLAND",
      "Orphanet:100091",
      "UMLS:C0001624"
    ],
    "synonyms": [
      "adrenal gland neoplasm (disease)",
      "adrenal gland tumor",
      "adrenal gland tumour",
      "adrenal neoplasm",
      "adrenal neoplasms",
      "adrenal tumor",
      "adrenal tumour",
      "neoplasm of adrenal gland",
      "neoplasm of the adrenal gland",
      "tumor of adrenal gland",
      "tumor of the adrenal gland",
      "tumour of adrenal gland",
      "tumour of the adrenal gland",
      "ADRENAL_GLAND",
      "adrenal/paraganglial tumor",
      "adrenal/paraganglial tumour"
    ],
    "categories": [
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A neoplasm (disease) that involves the adrenal gland."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 8,
  "parents": [
    {
      "id": 4223,
      "label": "endocrine gland neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6798,
        6875
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0003769",
          "ICD9:239.7",
          "MEDGEN:4044",
          "NCIT:C3010",
          "SCTID:387922007",
          "UMLS:C0014132"
        ],
        "synonyms": [
          "endocrine gland neoplasm (disease)",
          "endocrine gland tumor",
          "endocrine gland tumour",
          "endocrine neoplasm",
          "endocrine system neoplasm",
          "endocrine system tumor",
          "endocrine system tumour",
          "endocrine tumor",
          "endocrine tumour",
          "neoplasm of endocrine gland",
          "tumor of endocrine gland",
          "tumour of endocrine gland",
          "malignant endocrine tumor",
          "malignant endocrine tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign or malignant neoplasm arising from the epithelial cells of an endocrine organ. Representative examples include pituitary gland adenoma, pituitary gland carcinoma, thyroid gland carcinoma, carcinoid tumor, and neuroendocrine carcinoma."
      },
      "child_count": 28,
      "reference_id": "MONDO:0002082"
    },
    {
      "id": 7151,
      "label": "adrenal gland disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6875
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9553",
          "EFO:0005539",
          "ICD9:255",
          "ICD9:255.8",
          "ICD9:255.9",
          "MEDGEN:892577",
          "MESH:D000307",
          "NCIT:C26690",
          "SCTID:30171000",
          "UMLS:C4021794"
        ],
        "synonyms": [
          "adrenal gland disease",
          "adrenal gland disease or disorder",
          "adrenal gland diseases",
          "adrenal gland disorder",
          "adrenal gland disorders",
          "disease of adrenal gland",
          "disease or disorder of adrenal gland",
          "disorder of adrenal gland"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A disease involving the adrenal gland."
      },
      "child_count": 18,
      "reference_id": "MONDO:0005495"
    }
  ],
  "children": [
    {
      "id": 4843,
      "label": "adrenal gland cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7537,
        20310,
        20437
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3953",
          "GARD:0005751",
          "ICD10CM:C74",
          "ICD9:194.0",
          "ICD9:239.7",
          "MEDGEN:152909",
          "MESH:D000310",
          "NCIT:C9338",
          "SCTID:127021009",
          "UMLS:C0750887",
          "icd11.foundation:1766185236"
        ],
        "synonyms": [
          "adrenal neoplasm",
          "tumor of the adrenal gland",
          "tumour of the adrenal gland",
          "adrenal cancer",
          "adrenal gland cancer",
          "cancer of adrenal gland",
          "malignant adrenal gland neoplasm",
          "malignant adrenal gland tumor",
          "malignant adrenal gland tumour",
          "malignant adrenal neoplasm",
          "malignant adrenal tumor",
          "malignant adrenal tumour",
          "malignant neoplasm of adrenal gland",
          "malignant neoplasm of the adrenal gland",
          "malignant tumor of adrenal gland",
          "malignant tumor of the adrenal gland",
          "malignant tumour of adrenal gland",
          "malignant tumour of the adrenal gland"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant neoplasm involving the adrenal gland"
      },
      "child_count": 9,
      "reference_id": "MONDO:0002817"
    },
    {
      "id": 8921,
      "label": "multiple endocrine neoplasia type 1",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2903,
        16897,
        17512,
        20437
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10017",
          "GARD:0003829",
          "ICD10CM:E31.21",
          "ICD9:237.4",
          "ICD9:258.01",
          "MEDGEN:9957",
          "MESH:D018761",
          "MedDRA:10028190",
          "NANDO:2200405",
          "NCIT:C3225",
          "NORD:1466",
          "OMIM:131100",
          "Orphanet:652",
          "SCTID:30664006",
          "UMLS:C0025267",
          "icd11.foundation:1638765741"
        ],
        "synonyms": [
          "multiple endocrine adenomatosis",
          "MEA type 1",
          "MEA type I",
          "MEN1",
          "MEN1 multiple endocrine neoplasia",
          "MEN1 syndrome",
          "MEN1-related multiple endocrine neoplasia",
          "Wermer syndrome",
          "Wermer's syndrome",
          "men 1",
          "men type 1",
          "men type I",
          "multiple endocrine adenomatosis type 1",
          "multiple endocrine adenomatosis type I",
          "multiple endocrine adenomatosis, type I",
          "multiple endocrine neoplasia 1",
          "multiple endocrine neoplasia caused by mutation in MEN1",
          "multiple endocrine neoplasia type 1",
          "multiple endocrine neoplasia type 1 syndrome",
          "multiple endocrine neoplasia type I",
          "multiple endocrine neoplasia, type I",
          "MEA 1",
          "MEN1 somatic mutations",
          "endocrine adenomatosis multiple",
          "endocrine adenomatosis, multiple",
          "multiple endocrine neoplasia, type 1"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An autosomal dominant tumor predisposition syndrome caused by pathogenic variants in the MEN1 gene, characterized by an increased risk of tumors of the parathyroid glands, pituitary gland, and foregut neuroendocrine tumors (most commonly pancreatic islet cells)."
      },
      "child_count": 0,
      "reference_id": "MONDO:0007540"
    },
    {
      "id": 10301,
      "label": "Cushing disease due to pituitary adenoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5357,
        18043,
        19975,
        20437
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7004",
          "GARD:0012867",
          "MEDGEN:66381",
          "MESH:D049913",
          "MedDRA:10035109",
          "NANDO:1200379",
          "NANDO:2200350",
          "NCIT:C113210",
          "OMIM:219090",
          "Orphanet:96253",
          "SCTID:254958004",
          "UMLS:C0221406",
          "icd11.foundation:380861892"
        ],
        "synonyms": [
          "ACTH producing pituitary adenoma",
          "Cushing disease",
          "Cushing disease, pituitary",
          "Cushing's disease",
          "PITA4",
          "corticotroph pituitary adenoma",
          "pituitary adenoma 4, ACTH-secreting",
          "pituitary adenoma 4, ACTH-secreting, somatic",
          "pituitary adenoma, ACTH-secreting",
          "pituitary corticotroph micro-adenoma",
          "pituitary dependent Cushing syndrome",
          "pituitary-dependent Cushing syndrome",
          "ACTH-secreting pituitary adenoma",
          "Corticotropinoma",
          "corticotroph adenoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A form of adrenocorticotropic hormone (ACTH)-dependent Cushing syndrome, an endogenous Cushing syndrome (CS), characterized by chronic over-secretion of adrenocorticotropic hormone (ACTH) due to a pituitary corticotroph adenoma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0009050"
    },
    {
      "id": 19407,
      "label": "pituitary dermoid and epidermoid cysts",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        20437
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019161",
          "MEDGEN:1674582",
          "Orphanet:91351",
          "UMLS:C5190781"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0019615"
    },
    {
      "id": 20446,
      "label": "adrenal medulla neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20437
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025301",
          "MEDGEN:108572",
          "NCIT:C4856",
          "UMLS:C0596046"
        ],
        "synonyms": [
          "adrenal medulla neoplasm (disease)",
          "adrenal medulla tumor",
          "adrenal medulla tumour",
          "neoplasm of adrenal medulla",
          "tumor of adrenal medulla",
          "tumour of adrenal medulla"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A neoplasm (disease) that involves the adrenal medulla."
      },
      "child_count": 3,
      "reference_id": "MONDO:0021237"
    },
    {
      "id": 20630,
      "label": "benign neoplasm of adrenal gland",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3032,
        20437
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025326",
          "ICD10CM:D35.0",
          "ICD9:227.0",
          "MEDGEN:56330",
          "NCIT:C3629",
          "SCTID:91967007",
          "UMLS:C0154040",
          "icd11.foundation:2121003176"
        ],
        "synonyms": [
          "adrenal gland benign neoplasm",
          "benign adrenal gland neoplasm",
          "benign adrenal gland tumor",
          "benign adrenal gland tumour",
          "benign adrenal neoplasm",
          "benign adrenal tumor",
          "benign adrenal tumour",
          "benign neoplasm of the adrenal gland",
          "benign tumor of adrenal gland",
          "benign tumor of the adrenal gland",
          "benign tumour of adrenal gland",
          "benign tumour of the adrenal gland"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign neoplasm that involves the adrenal gland."
      },
      "child_count": 6,
      "reference_id": "MONDO:0021511"
    },
    {
      "id": 22865,
      "label": "pheochromocytoma-paraganglioma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        20437
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0022315",
          "MEDGEN:1826130",
          "Orphanet:573163",
          "UMLS:C5681712"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A rare neuroendocrine tumor arising from chromaffin cells of the adrenal medulla (pheochromocytoma) or from sympathetic and parasympathetic ganglia (paraganglioma). These tumors are most often benign and may produce catecholamines in excess causing hypertension and sometimes severe acute cardiovascular complications."
      },
      "child_count": 0,
      "reference_id": "MONDO:0035540"
    },
    {
      "id": 22943,
      "label": "adrenal cortex neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4842,
        20437
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025820",
          "MEDGEN:1350",
          "MESH:D000306",
          "NCIT:C2858",
          "UMLS:C0001618"
        ],
        "synonyms": [
          "adrenal cortex neoplasm",
          "adrenal cortex tumor",
          "adrenal cortex tumour",
          "adrenocortical neoplasm",
          "adrenocortical tumor",
          "adrenocortical tumour",
          "neoplasm of adrenal cortex",
          "tumor of adrenal cortex",
          "tumour of adrenal cortex"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign or malignant (primary or metastatic) neoplasm affecting the adrenal cortex. (NCI05)"
      },
      "child_count": 6,
      "reference_id": "MONDO:0036591"
    }
  ],
  "roots": [
    {
      "id": 4223,
      "label": "endocrine gland neoplasm"
    },
    {
      "id": 7151,
      "label": "adrenal gland disorder"
    }
  ]
}