{
  "id": 20442,
  "label": "pineal body neoplasm",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0021232",
  "properties": {
    "xrefs": [
      "MEDGEN:237252",
      "NCIT:C3328",
      "ONCOTREE:PINT",
      "UMLS:C1412004"
    ],
    "synonyms": [
      "neoplasm of pineal area",
      "neoplasm of pineal body",
      "neoplasm of pineal region",
      "neoplasm of the pineal area",
      "neoplasm of the pineal region",
      "pineal area neoplasm",
      "pineal area tumor",
      "pineal area tumour",
      "pineal body neoplasm (disease)",
      "pineal body tumor",
      "pineal body tumour",
      "pineal neoplasm",
      "pineal region neoplasm",
      "pineal region tumor",
      "pineal region tumour",
      "pineal tumor",
      "pineal tumour",
      "pinealoma",
      "tumor of pineal area",
      "tumor of pineal body",
      "tumor of pineal region",
      "tumor of the pineal area",
      "tumor of the pineal region",
      "tumour of pineal area",
      "tumour of pineal body",
      "tumour of pineal region",
      "tumour of the pineal area",
      "tumour of the pineal region"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A neoplasm (disease) that involves the pineal body."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 5,
  "parents": [
    {
      "id": 4223,
      "label": "endocrine gland neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6798,
        6875
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0003769",
          "ICD9:239.7",
          "MEDGEN:4044",
          "NCIT:C3010",
          "SCTID:387922007",
          "UMLS:C0014132"
        ],
        "synonyms": [
          "endocrine gland neoplasm (disease)",
          "endocrine gland tumor",
          "endocrine gland tumour",
          "endocrine neoplasm",
          "endocrine system neoplasm",
          "endocrine system tumor",
          "endocrine system tumour",
          "endocrine tumor",
          "endocrine tumour",
          "neoplasm of endocrine gland",
          "tumor of endocrine gland",
          "tumour of endocrine gland",
          "malignant endocrine tumor",
          "malignant endocrine tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign or malignant neoplasm arising from the epithelial cells of an endocrine organ. Representative examples include pituitary gland adenoma, pituitary gland carcinoma, thyroid gland carcinoma, carcinoid tumor, and neuroendocrine carcinoma."
      },
      "child_count": 28,
      "reference_id": "MONDO:0002082"
    },
    {
      "id": 5067,
      "label": "thalamic disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7209
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4662",
          "MEDGEN:52693",
          "MESH:D013786",
          "NCIT:C85186",
          "UMLS:C0039726"
        ],
        "synonyms": [
          "disease of dorsal plus ventral thalamus",
          "disease or disorder of dorsal plus ventral thalamus",
          "disorder of dorsal plus ventral thalamus",
          "dorsal plus ventral thalamus disease",
          "dorsal plus ventral thalamus disease or disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A disorder of the thalamus. Causes include brain neoplasms, cerebrovascular disorders, brain trauma, brain hypoxia, infections, and brain hemorrhage. Signs and symptoms include movement and sensory abnormalities, visual abnormalities, ataxia, and coma."
      },
      "child_count": 3,
      "reference_id": "MONDO:0003081"
    },
    {
      "id": 20429,
      "label": "brain neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7209,
        7694
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0003833",
          "MEDGEN:14216",
          "NCIT:C2907",
          "UMLS:C0006118"
        ],
        "synonyms": [
          "brain neoplasm (disease)",
          "brain neoplasms",
          "brain tumor",
          "brain tumour",
          "neoplasm of brain",
          "neoplasm of the brain",
          "tumor of brain",
          "tumor of the Brain",
          "tumour of brain",
          "tumour of the Brain"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A neoplasm (disease) that involves the brain."
      },
      "child_count": 34,
      "reference_id": "MONDO:0021211"
    },
    {
      "id": 23822,
      "label": "neuroendocrine disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6799,
        6875
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:1843486",
          "UMLS:C0541403"
        ],
        "synonyms": [
          "neuroendocrine system disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A disease or disorder that affects the neuroendocrine gland, any of the organized aggregations of cells that function as secretory or excretory organs and that release hormones in response to neural stimuli."
      },
      "child_count": 8,
      "reference_id": "MONDO:0100070"
    }
  ],
  "children": [
    {
      "id": 5194,
      "label": "pineal gland cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5646,
        20310,
        20442
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5032",
          "GARD:0027637",
          "ICD10CM:C75.3",
          "ICD9:194.4",
          "MEDGEN:102284",
          "NCIT:C3573",
          "SCTID:363483004",
          "UMLS:C0153655"
        ],
        "synonyms": [
          "neoplasm of the pineal region",
          "pineocytic tumor",
          "pineocytic tumour",
          "tumor of the pineal region",
          "tumour of the pineal region",
          "cancer of pineal body",
          "malignant neoplasm of pineal body",
          "malignant neoplasm of pineal gland",
          "malignant neoplasm of the pineal gland",
          "malignant pineal area neoplasm",
          "malignant pineal area tumor",
          "malignant pineal area tumour",
          "malignant pineal body neoplasm",
          "malignant pineal gland neoplasm",
          "malignant pineal gland tumor",
          "malignant pineal gland tumour",
          "malignant pineal region neoplasm",
          "malignant pineal region tumor",
          "malignant pineal region tumour",
          "malignant tumor of pineal gland",
          "malignant tumor of the pineal gland",
          "malignant tumour of pineal gland",
          "malignant tumour of the pineal gland",
          "pineal body cancer",
          "pinealoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Abnormal malignant growth of the cells that comprise the pineal parenchyma."
      },
      "child_count": 9,
      "reference_id": "MONDO:0003249"
    },
    {
      "id": 5864,
      "label": "pineal region teratoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4757,
        20442
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6856",
          "GARD:0023777",
          "MEDGEN:277517",
          "NCIT:C6753",
          "UMLS:C1335419"
        ],
        "synonyms": [
          "pineal area teratoma",
          "teratoma of pineal area",
          "teratoma of pineal region",
          "teratoma of the pineal area",
          "teratoma of the pineal region"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A mature or immature teratoma that arises in the pineal region."
      },
      "child_count": 6,
      "reference_id": "MONDO:0004015"
    },
    {
      "id": 6246,
      "label": "pineal region meningioma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        17113,
        20442
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8031",
          "GARD:0024006",
          "MEDGEN:235478",
          "NCIT:C6756",
          "UMLS:C1335418"
        ],
        "synonyms": [
          "meningioma (disease) of pineal body",
          "meningioma of pineal area",
          "meningioma of pineal gland",
          "meningioma of pineal region",
          "meningioma of the pineal area",
          "meningioma of the pineal gland",
          "meningioma of the pineal region",
          "pineal area meningioma",
          "pineal body meningioma (disease)",
          "pineal gland meningioma",
          "pineal meningioma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A meningioma that affects the pineal gland."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004440"
    },
    {
      "id": 17180,
      "label": "papillary tumor of the pineal region",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        20418,
        20442
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0081251",
          "GARD:0020725",
          "ICDO:9395/3",
          "MEDGEN:457445",
          "NCIT:C92624",
          "ONCOTREE:PTPR",
          "Orphanet:251915",
          "UMLS:C2985219"
        ],
        "synonyms": [
          "PTPR"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Papillary tumor of the pineal region (PTPR) is a very rare neoplasm of the pineal region that is thought to arise from the specialized ependymocytes of the subcommissural organ and that manifests with visual disturbances, headaches, loss of coordination and balance, nausea and vomiting due to obstructive hydrocephalus."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016724"
    },
    {
      "id": 21613,
      "label": "pineal parenchymal cell neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20418,
        20442
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICDO:9360/1",
          "NCIT:C6965"
        ],
        "synonyms": [
          "neoplasm of pineal gland",
          "neoplasm of the pineal gland",
          "pineal gland neoplasm",
          "pineal gland tumor",
          "pineal gland tumour",
          "pineal parenchymal cell neoplasm",
          "pineal parenchymal cell tumor",
          "pineal parenchymal cell tumour",
          "pineal parenchymal neoplasm",
          "pineal parenchymal tumor",
          "pineal parenchymal tumour",
          "pineocytic neoplasm",
          "pineocytic tumor",
          "pineocytic tumour",
          "tumor of pineal gland",
          "tumor of the pineal gland",
          "tumour of pineal gland",
          "tumour of the pineal gland"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A neoplasm arising from the pineocyte, a cell with photosensory and neuroendocrine functions. It may be composed of mature elements or primitive, immature cells. The cellular composition determines the biological behavior and clinical outcome. Three types are recognized: pineoblastoma, pineocytoma, and pineal parenchymal tumor of intermediate differentiation (Adapted from WHO.)"
      },
      "child_count": 6,
      "reference_id": "MONDO:0024890"
    }
  ],
  "roots": [
    {
      "id": 4223,
      "label": "endocrine gland neoplasm"
    },
    {
      "id": 5067,
      "label": "thalamic disorder"
    },
    {
      "id": 20429,
      "label": "brain neoplasm"
    },
    {
      "id": 23822,
      "label": "neuroendocrine disorder"
    }
  ]
}