{
  "id": 20456,
  "label": "nervous system neoplasm",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0021248",
  "properties": {
    "xrefs": [
      "MEDGEN:45046",
      "NCIT:C3268",
      "UMLS:C0027766"
    ],
    "synonyms": [
      "neoplasm of nervous system",
      "neoplasm of the nervous system",
      "nervous system neoplasm (disease)",
      "nervous system neoplasms",
      "nervous system tumor",
      "nervous system tumour",
      "tumor of nervous system",
      "tumor of the nervous system",
      "tumour of nervous system",
      "tumour of the nervous system"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "A neoplasm (disease) that involves the nervous system."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 7,
  "parents": [
    {
      "id": 6798,
      "label": "neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        21214
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:14566",
          "EFO:0000616",
          "HP:0002664",
          "ICD10CM:C00-D49",
          "ICD10CM:C7A-C7A",
          "ICD10CM:C7B-C7B",
          "ICD9:140-239",
          "ICD9:239.8",
          "ICD9:239.9",
          "MEDGEN:10294",
          "MESH:D009369",
          "NCIT:C3262",
          "ONCOTREE:OTHER",
          "SCTID:55342001",
          "UMLS:C0027651"
        ],
        "synonyms": [
          "cell process disease",
          "disease of cellular proliferation",
          "neoplasia",
          "neoplasm",
          "neoplasm (disease)",
          "neoplastic disease",
          "neoplastic growth",
          "tumor",
          "tumor disease",
          "tumour",
          "tumour disease",
          "other neoplasm"
        ],
        "definition": "A benign or malignant tissue growth resulting from uncontrolled cell proliferation. Benign neoplastic cells resemble normal cells without exhibiting significant cytologic atypia, while malignant cells exhibit overt signs such as dysplastic features, atypical mitotic figures, necrosis, nuclear pleomorphism, and anaplasia. Representative examples of benign neoplasms include papillomas, cystadenomas, and lipomas; malignant neoplasms include carcinomas, sarcomas, lymphomas, and leukemias."
      },
      "child_count": 48,
      "reference_id": "MONDO:0005070"
    },
    {
      "id": 6799,
      "label": "nervous system disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29379
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:863",
          "EFO:0000618",
          "ICD10CM:G00-G99",
          "ICD9:349.89",
          "ICD9:349.9",
          "MEDGEN:14336",
          "MESH:D009422",
          "NCIT:C26835",
          "SCTID:118940003",
          "UMLS:C0027765",
          "Wikipedia:Nervous_system_disease"
        ],
        "synonyms": [
          "disease of nervous system",
          "disease or disorder of nervous system",
          "disorder of nervous system",
          "nervous system disease",
          "nervous system disease or disorder",
          "nervous system disorder",
          "neurologic disease",
          "neurologic disorder",
          "neurological disease",
          "neurological disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A non-neoplastic or neoplastic disorder that affects the brain, spinal cord, or peripheral nerves."
      },
      "child_count": 72,
      "reference_id": "MONDO:0005071"
    }
  ],
  "children": [
    {
      "id": 3049,
      "label": "nervous system benign neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6887,
        20456
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060115",
          "ICD9:225.8",
          "ICD9:225.9",
          "MEDGEN:99232",
          "NCIT:C4789",
          "SCTID:92247009",
          "UMLS:C0497550"
        ],
        "synonyms": [
          "benign neoplasm of nervous system",
          "benign neoplasm of the nervous system",
          "benign nervous system neoplasm",
          "benign nervous system tumor",
          "benign nervous system tumour",
          "benign tumor of nervous system",
          "benign tumor of the nervous system",
          "benign tumour of nervous system",
          "benign tumour of the nervous system",
          "nervous system benign neoplasm",
          "nervous system neoplasm, benign"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Abnormal growth of cells in the nervous system without evidence of malignant characteristics. Unlike other organ systems, tumors in the central nervous system can have benign histological characteristics but still have life threatening effects due to their location within the neuraxis (e.g., brainstem gliomas)."
      },
      "child_count": 10,
      "reference_id": "MONDO:0000648"
    },
    {
      "id": 3627,
      "label": "peripheral nervous system neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5512,
        20456
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1192",
          "EFO:0002431",
          "ICD9:239.2",
          "MEDGEN:45817",
          "MESH:D010524",
          "NCIT:C3321",
          "ONCOTREE:PNS",
          "SCTID:126980002",
          "UMLS:C0031118"
        ],
        "synonyms": [
          "PNS neoplasm",
          "PNS neoplasms",
          "PNS tumor",
          "PNS tumour",
          "neoplasm of PNS",
          "neoplasm of peripheral nerve",
          "neoplasm of peripheral nervous system",
          "neoplasm of the PNS",
          "neoplasm of the peripheral nerve",
          "neoplasm of the peripheral nervous system",
          "neoplasms, PNS",
          "neoplasms, peripheral nervous system",
          "peripheral nerve neoplasm",
          "peripheral nerve tumor",
          "peripheral nerve tumour",
          "peripheral nervous system neoplasm",
          "peripheral nervous system neoplasm (disease)",
          "peripheral nervous system tumor",
          "peripheral nervous system tumour",
          "tumor of PNS",
          "tumor of peripheral nerve",
          "tumor of peripheral nervous system",
          "tumor of the PNS",
          "tumor of the peripheral nerve",
          "tumor of the peripheral nervous system",
          "tumour of PNS",
          "tumour of peripheral nerve",
          "tumour of peripheral nervous system",
          "tumour of the PNS",
          "tumour of the peripheral nerve",
          "tumour of the peripheral nervous system",
          "CNS-excluded nervous sys. cancer",
          "nerve sheath neoplasm",
          "nerve sheath tumors",
          "nerve sheath tumours"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A benign or malignant neoplasm arising from a peripheral nerve or the perineural sheaths."
      },
      "child_count": 18,
      "reference_id": "MONDO:0001406"
    },
    {
      "id": 7479,
      "label": "nervous system cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733,
        20456
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3093",
          "EFO:0007392",
          "ICD9:192",
          "ICD9:192.8",
          "ICD9:192.9",
          "MEDGEN:99231",
          "MESH:D009423",
          "NCIT:C4788",
          "SCTID:372063002",
          "UMLS:C0497549"
        ],
        "synonyms": [
          "nervous system neoplasm",
          "neural neoplasm",
          "neural tumor",
          "neural tumour",
          "tumor of the nervous system",
          "tumour of the nervous system",
          "cancer of nervous system",
          "malignant neoplasm of nervous system",
          "malignant neoplasm of the nervous system",
          "malignant nervous system neoplasm",
          "malignant nervous system tumor",
          "malignant nervous system tumour",
          "malignant tumor of nervous system",
          "malignant tumor of the nervous system",
          "malignant tumour of nervous system",
          "malignant tumour of the nervous system",
          "nervous system cancer",
          "nervous system neoplasms, malignant"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A primary or metastatic malignant neoplasm involving the nervous system."
      },
      "child_count": 12,
      "reference_id": "MONDO:0005872"
    },
    {
      "id": 7694,
      "label": "central nervous system neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4657,
        20456
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000158",
          "MEDGEN:88335",
          "NCIT:C9293",
          "UMLS:C0085136"
        ],
        "synonyms": [
          "CNS neoplasm",
          "CNS tumor",
          "CNS tumour",
          "brain/spinal cord tumor",
          "brain/spinal cord tumour",
          "central nervous system neoplasm",
          "central nervous system neoplasm (disease)",
          "central nervous system tumor",
          "central nervous system tumour",
          "neoplasm of CNS",
          "neoplasm of central nervous system",
          "neoplasm of the central nervous system",
          "tumor of CNS",
          "tumor of central nervous system",
          "tumor of the CNS",
          "tumor of the central nervous system",
          "tumour of CNS",
          "tumour of central nervous system",
          "tumour of the CNS",
          "tumour of the central nervous system"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A benign or malignant, primary or metastatic neoplasm that affects the brain, meninges, or spinal cord. Representative examples of primary neoplasms include astrocytoma, oligodendroglioma, ependymoma, and meningioma. Representative examples of metastatic neoplasms include carcinoma and leukemia."
      },
      "child_count": 20,
      "reference_id": "MONDO:0006130"
    },
    {
      "id": 17197,
      "label": "tumor of cranial and spinal nerves",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20456
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0012697",
          "MEDGEN:1842705",
          "Orphanet:252057",
          "UMLS:C5679636"
        ],
        "synonyms": [
          "rare tumor of cranial and spinal nerves",
          "rare tumour of cranial and spinal nerves"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 4,
      "reference_id": "MONDO:0016749"
    },
    {
      "id": 20418,
      "label": "neuroepithelial neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20456
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:60215",
          "MESH:D018302",
          "NCIT:C3787",
          "ONCOTREE:PRNET",
          "UMLS:C0206715"
        ],
        "synonyms": [
          "neoplasm of neuroepithelial tissue",
          "neoplasm of neuroepithelium",
          "neoplasm of the neuroepithelium",
          "neuroepithelial neoplasm",
          "neuroepithelial neoplasms",
          "neuroepithelial tissue neoplasm",
          "neuroepithelial tissue tumor",
          "neuroepithelial tissue tumour",
          "neuroepithelial tumor",
          "neuroepithelial tumors",
          "neuroepithelial tumour",
          "neuroepithelial tumours",
          "tumor of neuroepithelial tissue",
          "tumor of neuroepithelium",
          "tumor of the neuroepithelium",
          "tumour of neuroepithelial tissue",
          "tumour of neuroepithelium",
          "tumour of the neuroepithelium",
          "primary neuroepithelial tumor",
          "primary neuroepithelial tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A neoplasm of the nervous system that arises from the neuroepithelial tissues. Representative examples include astrocytic tumors, oligodendroglial tumors, ependymal tumors, and primitive neuroectodermal tumors."
      },
      "child_count": 6,
      "reference_id": "MONDO:0021193"
    },
    {
      "id": 20441,
      "label": "retina neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6979,
        20431,
        20456
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000509",
          "MEDGEN:101180",
          "NCIT:C4800",
          "UMLS:C0524801"
        ],
        "synonyms": [
          "neoplasm of retina",
          "neoplasm of the retina",
          "retina neoplasm (disease)",
          "retina tumor",
          "retina tumour",
          "retinal neoplasm",
          "retinal tumor",
          "retinal tumour",
          "tumor of retina",
          "tumor of the retina",
          "tumour of retina",
          "tumour of the retina"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A neoplasm (disease) that involves the retina."
      },
      "child_count": 15,
      "reference_id": "MONDO:0021231"
    }
  ],
  "roots": [
    {
      "id": 6798,
      "label": "neoplasm"
    },
    {
      "id": 6799,
      "label": "nervous system disorder"
    }
  ]
}