{
  "id": 20466,
  "label": "inherited orthostatic hypotension",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0021272",
  "properties": {
    "xrefs": [
      "GARD:0021878",
      "MEDGEN:1842591",
      "OMIMPS:223360",
      "Orphanet:448426",
      "UMLS:C5681106"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ]
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 16612,
      "label": "primary orthostatic hypotension",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6799
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:1842969",
          "Orphanet:182058",
          "UMLS:C5680599"
        ],
        "synonyms": [
          "neurogenic orthostatic hypotension"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Primary orthostatic hypotension is a rare type of orthostatic hypotension. It is not a disease per se, but a condition caused by several disorders that affect a specific part of the autonomic nervous system, such as multiple system atrophy, young-onset Parkinson's disease, pure autonomic failure, dopamine beta-hydroxylase deficiency, familial dysautonomia, and pure autonomic failure among others. The autonomic nervous system is the part of the nervous system that regulates certain involuntary body functions such as heart rate, blood pressure, sweating, and bowel and bladder control. Orthostatic hypotension is a form of low blood pressure that happens when standing-up from sitting or lying down. Common symptoms may include dizziness, lightheadedness, generalized weakness, leg buckling, nausea, blurry vision, fatigue, and headaches. Additional symptoms can include chest pain (angina), head and neck pain (often affecting neck and shoulders with a coat hanger distribution), decline in cognitive functioning such as difficulty concentrating, temporary loss of consciousness or “blackout”. Some people with primary orthostatic hypotension may also have high blood pressure when lying down. The treatment depends upon several factors including the specific underlying cause including The treatment depends upon several factors including the specific underlying cause and may include physical counter-maneuvers like lying down, sitting down, squatting clenching buttocks, leg crossing, and support garment and medication."
      },
      "child_count": 2,
      "reference_id": "MONDO:0015914"
    },
    {
      "id": 24270,
      "label": "hereditary neurological disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5714,
        6799
      ],
      "type_id": 0,
      "properties": {
        "synonyms": [
          "neurogenetic disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A heterogeneous group of genetic conditions with Mendelian (autosomal dominant, recessive, or X-linked) or chromosomal etiology characterized by abnormalities in the brain, spinal cord, nerves, or muscles."
      },
      "child_count": 528,
      "reference_id": "MONDO:0100545"
    }
  ],
  "children": [
    {
      "id": 10368,
      "label": "orthostatic hypotension 1",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        17985,
        20466
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0090145",
          "GARD:0001903",
          "ICD9:270.8",
          "MEDGEN:1648402",
          "MESH:C535600",
          "NANDO:2200597",
          "OMIM:223360",
          "Orphanet:230",
          "SCTID:237923004",
          "UMLS:C4746777"
        ],
        "synonyms": [
          "dopamine beta-hydroxylase deficiency",
          "noradrenaline deficiency",
          "norepinephrine deficiency",
          "orthostatic hypotension 1, due to DBH deficiency",
          "dopamine BETA-HYDROXYLASE deficiency, congenital",
          "dopamine beta hydroxylase deficiency"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A very rare primary monoamine neurotransmitter synthesis disorder with norepinephrine and adrenaline deficiency that leads to young-onset severe orthostatic hypotension and eyelid ptosis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0009123"
    },
    {
      "id": 12581,
      "label": "postural orthostatic tachycardia syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3258,
        20466,
        24272
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0111154",
          "EFO:1000645",
          "GARD:0013591",
          "MEDGEN:226970",
          "MESH:D054972",
          "NCIT:C85020",
          "OMIM:604715",
          "Orphanet:443236",
          "SCTID:371073003",
          "UMLS:C1299624",
          "icd11.foundation:1533647472"
        ],
        "synonyms": [
          "POTS",
          "familial orthostatic tachycardia due to norepinephrine transporter deficiency",
          "irritable heart",
          "orthostatic intolerance due to NET deficiency",
          "soldiers heart",
          "Soldiers heart",
          "neurocirculatory asthenia",
          "orthostatic intolerance"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A condition characterized by development of symptoms while standing. It is an autonomic nervous system disorder and the symptoms are relieved once the person sits back down. Symptoms include heart."
      },
      "child_count": 0,
      "reference_id": "MONDO:0011479"
    },
    {
      "id": 20154,
      "label": "orthostatic hypotension 2",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        20466
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025238",
          "MEDGEN:1648282",
          "OMIM:618182",
          "UMLS:C4748569"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0020751"
    }
  ],
  "roots": [
    {
      "id": 16612,
      "label": "primary orthostatic hypotension"
    },
    {
      "id": 24270,
      "label": "hereditary neurological disease"
    }
  ]
}