{
  "id": 20528,
  "label": "leukemia, myeloid, accelerated-phase",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0021367",
  "properties": {
    "xrefs": [
      "GARD:0025315",
      "MEDGEN:6059",
      "MESH:D015465",
      "NCIT:C3173",
      "UMLS:C0023472"
    ],
    "synonyms": [
      "Accelerated Phase CML",
      "Accelerated Phase Chronic Granulocytic Leukaemia",
      "Accelerated Phase Chronic Granulocytic Leukemia",
      "Accelerated Phase Chronic Myelocytic Leukaemia",
      "Accelerated Phase Chronic Myelocytic Leukemia",
      "Accelerated Phase Chronic Myelogenous Leukaemia",
      "Accelerated Phase Chronic Myelogenous Leukemia",
      "Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive",
      "Accelerated Phase Chronic Myeloid Leukaemia",
      "Accelerated Phase Chronic Myeloid Leukemia",
      "Accelerated phase chronic myeloid leukaemia",
      "Accelerated phase chronic myeloid leukemia",
      "Aggressive-Phase CML",
      "Aggressive-Phase Chronic Myelocytic Leukaemia",
      "Aggressive-Phase Chronic Myelocytic Leukemia",
      "Aggressive-Phase Chronic Myelogenous Leukaemia",
      "Aggressive-Phase Chronic Myelogenous Leukemia",
      "Aggressive-Phase Chronic Myeloid Leukaemia",
      "Aggressive-Phase Chronic Myeloid Leukemia",
      "CML ACCELERATED",
      "CML AGGRESSIVE",
      "Leukemia, Myelogenous, Aggressive Phase",
      "Leukemia, Myelogenous, Aggressive-Phase",
      "Leukemia, Myeloid, Accelerated Phase",
      "Leukemia, Myeloid, Accelerated-Phase",
      "Leukemia, Myeloid, Aggressive-Phase",
      "Myelogenous Leukemia, Chronic, Aggressive Phase",
      "Myelogenous Leukemia, Chronic, Aggressive-Phase",
      "Myeloid Leukemia, Chronic, Accelerated Phase",
      "Myeloid Leukemia, Chronic, Accelerated-Phase",
      "Myeloid Leukemia, Chronic, Aggressive Phase",
      "Myeloid Leukemia, Chronic, Aggressive-Phase"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0003900",
        "name": "connective tissue disorder"
      },
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "The phase of chronic myeloid leukemia following the chronic phase (leukemia, myeloid, chronic-phase), where there are increased systemic symptoms, worsening cytopenias, and refractory leukocytosis."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 13067,
      "label": "chronic myelogenous leukemia, BCR-ABL1 positive",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6429,
        21247
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0081088",
          "DOID:8552",
          "EFO:0000339",
          "GARD:0006105",
          "ICD9:205.1",
          "ICDO:9863/3",
          "ICDO:9875/3",
          "MEDGEN:75993",
          "MedDRA:10009013",
          "NANDO:2200013",
          "NCIT:C3174",
          "OMIM:608232",
          "ONCOTREE:CML",
          "Orphanet:521",
          "UMLS:C0279543"
        ],
        "synonyms": [
          "BCR-ABL Positive chronic myelogenous leukaemia",
          "BCR-ABL Positive chronic myelogenous leukemia",
          "CML",
          "CML - chronic myelogenous leukaemia",
          "CML - chronic myelogenous leukemia",
          "chronic granulocytic leukemia",
          "chronic myelocytic leukaemia",
          "chronic myelocytic leukemia",
          "chronic myelogenous leukaemia (CML)",
          "chronic myelogenous leukemia",
          "chronic myelogenous leukemia (CML)",
          "chronic myelogenous leukemia, BCR-ABL1 Positive",
          "chronic myelogenous leukemias",
          "chronic myeloid leukemia",
          "hematopoeitic - chronic myelocytic leukaemia (CML)",
          "hematopoeitic - chronic myelocytic leukemia (CML)",
          "leukemia, Philadelphia chromosome-positive, resistant to imatinib, Somatic mutation",
          "leukemia, chronic myeloid, Philadelphia chromosome positive, somatic",
          "myeloid leukemia, chronic",
          "leukemia, chronic myelogenous",
          "leukemia, chronic myeloid",
          "leukemia, chronic myeloid, atypical"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A chronic myeloproliferative neoplasm characterized by the expression of the BCR-ABL1 fusion gene. It presents with neutrophilic leukocytosis. It can appear at any age, but it mostly affects middle aged and older individuals. Patients usually present with fatigue, weight loss, anemia, night sweats, and splenomegaly. If untreated, it follows a biphasic or triphasic natural course; an initial indolent chronic phase which is followed by an accelerated phase, a blast phase, or both. Allogeneic stem cell transplantation and tyrosine kinase inhibitors delay disease progression and prolong overall survival."
      },
      "child_count": 6,
      "reference_id": "MONDO:0011996"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 13067,
      "label": "chronic myelogenous leukemia, BCR-ABL1 positive"
    }
  ]
}