{
  "id": 20650,
  "label": "intestinal neuroendocrine tumor G1",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0021533",
  "properties": {
    "xrefs": [
      "GARD:0025331",
      "MEDGEN:138099",
      "MESH:C562842",
      "NCIT:C4637",
      "OMIM:114900",
      "SCTID:276816003",
      "UMLS:C0349535"
    ],
    "synonyms": [
      "carcinoid tumor of intestine",
      "carcinoid tumor of the intestine",
      "carcinoid tumour of intestine",
      "carcinoid tumour of the intestine",
      "grade 1 neuroendocrine neoplasm of intestine",
      "intestinal NET G1",
      "intestinal carcinoid tumor",
      "intestinal carcinoid tumour",
      "intestinal neuroendocrine tumor G1",
      "intestine NET G1",
      "intestine carcinoid tumor",
      "intestine carcinoid tumor (disease)",
      "intestine carcinoid tumour",
      "intestine carcinoid tumour (disease)",
      "intestine neuroendocrine neoplasm G1",
      "intestine neuroendocrine tumor, well differentiated, low grade"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A well differentiated, low grade neuroendocrine tumor (carcinoid tumor) that arises from the small or large intestine. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 2885,
      "label": "digestive system neuroendocrine tumor, grade 1/2",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        21456
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050626",
          "GARD:0022761",
          "MEDGEN:443945",
          "NCIT:C95404",
          "ONCOTREE:GINET",
          "UMLS:C2930967"
        ],
        "synonyms": [
          "alimentary part of gastrointestinal system neuroendocrine tumor",
          "alimentary part of gastrointestinal system neuroendocrine tumour",
          "digestive system NET",
          "digestive system neuroendocrine tumor",
          "digestive system neuroendocrine tumour",
          "digestive system well differentiated neuroendocrine tumor",
          "digestive system well differentiated neuroendocrine tumour",
          "gastroenteropancreatic NET",
          "gastroenteropancreatic neuroendocrine tumor",
          "gastroenteropancreatic neuroendocrine tumour",
          "gastrointestinal NET",
          "gastrointestinal neuroendocrine tumor",
          "gastrointestinal neuroendocrine tumors",
          "gastrointestinal neuroendocrine tumour",
          "gastrointestinal neuroendocrine tumours",
          "gastrointestinal system neuroendocrine tumor",
          "gastrointestinal system neuroendocrine tumour",
          "malignant gastrointestinal neuroendocrine tumor",
          "malignant gastrointestinal neuroendocrine tumour",
          "GINET"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A well-differentiated neuroendocrine tumor arising from the digestive system. It is characterized by the presence of cells with features similar to those of the normal endocrine cells of the digestive system. The neoplastic cells express immunohistochemical evidence of neuroendocrine differentiation and hormones. There is mild to moderate nuclear atypia and less than 20 mitoses per 10 HPF. It includes well-differentiated endocrine tumors or carcinoid tumors and well-differentiated endocrine carcinomas."
      },
      "child_count": 10,
      "reference_id": "MONDO:0000386"
    },
    {
      "id": 4896,
      "label": "intestinal neuroendocrine neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20357,
        21456
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4119",
          "GARD:0023287",
          "MEDGEN:233567",
          "NCIT:C5695",
          "UMLS:C1334231"
        ],
        "synonyms": [
          "intestinal neuroendocrine neoplasm",
          "intestine NET",
          "intestine neuroendocrine neoplasm",
          "intestine neuroendocrine tumor",
          "intestine neuroendocrine tumor, well differentiated, low or intermediate grade",
          "intestine neuroendocrine tumour",
          "neuroendocrine neoplasm of intestine",
          "neuroendocrine neoplasm of the intestine",
          "intestinal neuroendocrine benign tumor",
          "intestinal neuroendocrine benign tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A neoplasm with neuroendocrine differentiation that arises from the small or large intestine. It includes well differentiated neuroendocrine tumors (low and intermediate grade) and poorly differentiated neuroendocrine carcinomas (high grade)."
      },
      "child_count": 8,
      "reference_id": "MONDO:0002883"
    },
    {
      "id": 7051,
      "label": "carcinoid tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19314
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0004243",
          "GARD:0024176",
          "HP:0100570",
          "ICD9:209.60",
          "ICDO:8240/3",
          "ICDO:8241/3",
          "MEDGEN:2838",
          "MESH:D002276",
          "NANDO:2200396",
          "NCIT:C2915",
          "SCTID:443492008",
          "UMLS:C0007095"
        ],
        "synonyms": [
          "NET G1",
          "carcinoid",
          "carcinoid tumor",
          "carcinoid tumor (disease)",
          "carcinoid tumour (disease)",
          "neuroendocrine neoplasm G1",
          "neuroendocrine tumor G1",
          "neuroendocrine tumour G1"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A slow growing neuroendocrine tumor, composed of uniform, round, or polygonal cells having monotonous, centrally located nuclei and small nucleoli, infrequent mitoses, and no necrosis. The tumor may show a variety of patterns, such as solid, trabecular, and acinar. Electron microscopy shows small secretory granules. Immunohistochemical studies reveal NSE, as well as chromogranin immunoreactivity. Malignant histology (cellular pleomorphism, hyperchromatic nuclei, prominent nucleoli, necrosis, and mitoses) can occasionally be seen. Such cases may have an aggressive clinical course. Gastrointestinal tract and lung are common sites of involvement."
      },
      "child_count": 7,
      "reference_id": "MONDO:0005369"
    }
  ],
  "children": [
    {
      "id": 2982,
      "label": "small intestinal neuroendocrine tumor G1",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4994,
        20650
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050925",
          "GARD:0022796",
          "MEDGEN:91150",
          "NCIT:C4638",
          "SCTID:276818002",
          "UMLS:C0349536"
        ],
        "synonyms": [
          "carcinoid tumor of small bowel",
          "carcinoid tumor of small intestine",
          "carcinoid tumor of the small bowel",
          "carcinoid tumor of the small intestine",
          "carcinoid tumour of small bowel",
          "carcinoid tumour of small intestine",
          "carcinoid tumour of the small bowel",
          "carcinoid tumour of the small intestine",
          "grade 1 neuroendocrine neoplasm of small intestine",
          "small bowel carcinoid tumor",
          "small bowel carcinoid tumour",
          "small intestinal NET G1",
          "small intestinal carcinoid tumor",
          "small intestinal carcinoid tumour",
          "small intestinal neuroendocrine tumor G1",
          "small intestine NET G1",
          "small intestine carcinoid tumor",
          "small intestine carcinoid tumor (disease)",
          "small intestine carcinoid tumour",
          "small intestine carcinoid tumour (disease)",
          "small intestine neuroendocrine neoplasm G1",
          "small intestine neuroendocrine tumor, well differentiated, low grade",
          "small intestine carcinoid neuroendocrine tumor",
          "small intestine carcinoid neuroendocrine tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A well differentiated, low grade neuroendocrine tumor (carcinoid tumor) that arises from the small intestine. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent."
      },
      "child_count": 4,
      "reference_id": "MONDO:0000540"
    },
    {
      "id": 7723,
      "label": "colorectal neuroendocrine tumor G1",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7022,
        20650
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000195",
          "GARD:0024315",
          "MEDGEN:474244",
          "NCIT:C96160",
          "UMLS:C3272611"
        ],
        "synonyms": [
          "colorectal NET G1",
          "colorectal carcinoid tumor",
          "colorectal carcinoid tumour",
          "colorectal neuroendocrine tumor G1",
          "colorectum NET G1",
          "colorectum carcinoid tumor",
          "colorectum carcinoid tumour",
          "colorectum neuroendocrine neoplasm G1",
          "colorectum neuroendocrine tumor, well differentiated, low grade",
          "grade 1 neuroendocrine neoplasm of colorectum",
          "large intestinal neuroendocrine tumor G1",
          "large intestinal neuroendocrine tumour G1"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A well differentiated, low grade neuroendocrine tumor (carcinoid tumor) that arises from the colon or rectum. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent."
      },
      "child_count": 4,
      "reference_id": "MONDO:0006162"
    }
  ],
  "roots": [
    {
      "id": 2885,
      "label": "digestive system neuroendocrine tumor, grade 1/2"
    },
    {
      "id": 4896,
      "label": "intestinal neuroendocrine neoplasm"
    },
    {
      "id": 7051,
      "label": "carcinoid tumor"
    }
  ]
}