{
  "id": 20652,
  "label": "pancreatic neuroendocrine tumor G1",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0021535",
  "properties": {
    "xrefs": [
      "GARD:0025333",
      "MEDGEN:459467",
      "NCIT:C95584",
      "SCTID:254613007",
      "UMLS:C2987241"
    ],
    "synonyms": [
      "grade 1 neuroendocrine neoplasm of pancreas",
      "pancreas NET G1",
      "pancreas carcinoid tumor",
      "pancreas carcinoid tumour",
      "pancreas neuroendocrine neoplasm G1",
      "pancreas neuroendocrine tumor, well differentiated, low grade",
      "pancreatic NET G1",
      "pancreatic neuroendocrine tumor G1"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A low grade well differentiated tumor with neuroendocrine differentiation that arises from the pancreas. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal or less than 2%."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 7051,
      "label": "carcinoid tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19314
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0004243",
          "GARD:0024176",
          "HP:0100570",
          "ICD9:209.60",
          "ICDO:8240/3",
          "ICDO:8241/3",
          "MEDGEN:2838",
          "MESH:D002276",
          "NANDO:2200396",
          "NCIT:C2915",
          "SCTID:443492008",
          "UMLS:C0007095"
        ],
        "synonyms": [
          "NET G1",
          "carcinoid",
          "carcinoid tumor",
          "carcinoid tumor (disease)",
          "carcinoid tumour (disease)",
          "neuroendocrine neoplasm G1",
          "neuroendocrine tumor G1",
          "neuroendocrine tumour G1"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A slow growing neuroendocrine tumor, composed of uniform, round, or polygonal cells having monotonous, centrally located nuclei and small nucleoli, infrequent mitoses, and no necrosis. The tumor may show a variety of patterns, such as solid, trabecular, and acinar. Electron microscopy shows small secretory granules. Immunohistochemical studies reveal NSE, as well as chromogranin immunoreactivity. Malignant histology (cellular pleomorphism, hyperchromatic nuclei, prominent nucleoli, necrosis, and mitoses) can occasionally be seen. Such cases may have an aggressive clinical course. Gastrointestinal tract and lung are common sites of involvement."
      },
      "child_count": 7,
      "reference_id": "MONDO:0005369"
    },
    {
      "id": 19671,
      "label": "pancreatic neuroendocrine tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2885,
        7431
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000045",
          "GARD:0013034",
          "ICDO:8150/1",
          "MEDGEN:277875",
          "NCIT:C27720",
          "ONCOTREE:PANET",
          "Orphanet:97253",
          "UMLS:C1337011"
        ],
        "synonyms": [
          "islet cell tumor",
          "islet cell tumors - pancreas",
          "islet cell tumors of the pancreas",
          "islet cell tumour",
          "islet cell tumours - pancreas",
          "islet cell tumours of the pancreas",
          "pancreatic NET",
          "pancreatic neuroendocrine tumor",
          "well differentiated pancreatic endocrine neoplasm",
          "well differentiated pancreatic endocrine tumor",
          "well differentiated pancreatic endocrine tumour",
          "well-differentiated NEN of pancreas",
          "well-differentiated neuroendocrine neoplasm of pancreas",
          "well-differentiated pancreatic NEN",
          "well-differentiated pancreatic neuroendocrine neoplasm",
          "PANET",
          "neuroendocrine tumor of pancreas",
          "neuroendocrine tumour of pancreas",
          "pancreatic endocrine tumor",
          "pancreatic endocrine tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Pancreatic endocrine tumor, also known as pancreatic neuroendocrine tumor (PNET), describes a group of endocrine tumors originating in the pancreas that are usually indolent and benign, but may have the potential to be malignant. They can be functional, exhibiting a hormonal hypersecretion syndrome, but can be non-functional presenting with non-specific symptoms and include insulinoma, glucagonoma, VIPoma, somatostatinoma (SSoma), PPoma and Zollinger-Ellison syndrome (ZES, or gastrinoma) and other ectopic hormone producing tumors (such as GRFoma)."
      },
      "child_count": 22,
      "reference_id": "MONDO:0019954"
    }
  ],
  "children": [
    {
      "id": 21457,
      "label": "enterochromaffin cell serotonin-producing pancreatic neuroendocrine tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        20652
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0022055",
          "MEDGEN:91057",
          "NCIT:C4446",
          "Orphanet:506090",
          "UMLS:C0345933"
        ],
        "synonyms": [
          "EC cell, serotonin producing pancreatic NET",
          "EC cell, serotonin producing pancreatic neuroendocrine tumor",
          "EC cell, serotonin producing pancreatic neuroendocrine tumour",
          "carcinoid neoplasm of pancreas",
          "carcinoid neoplasm of the pancreas",
          "carcinoid tumor of pancreas",
          "carcinoid tumor of the pancreas",
          "carcinoid tumour of pancreas",
          "carcinoid tumour of the pancreas",
          "enterochromaffin cell serotonin-producing pancreatic neuroendocrine tumor",
          "pancreatic carcinoid tumor",
          "pancreatic carcinoid tumour",
          "pancreatic serotonin producing neoplasm",
          "pancreatic serotonin producing tumor",
          "pancreatic serotonin producing tumour",
          "serotonin-producing PNET",
          "serotonin-producing pancreatic NET",
          "serotonin-producing pancreatic neuroendocrine tumor",
          "serotonin-producing pancreatic neuroendocrine tumour",
          "serotonin-producing tumor of pancreas",
          "serotonin-producing tumor of the pancreas",
          "serotonin-producing tumour of pancreas",
          "serotonin-producing tumour of the pancreas",
          "serotonin-producing neuroendocrine tumor of pancreas",
          "serotonin-producing neuroendocrine tumour of pancreas"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A usually slow-growing, grade 1 pancreatic neuroendocrine tumor that secretes serotonin. When it metastasizes to the liver, it produces the clinical symptoms of the carcinoid syndrome."
      },
      "child_count": 0,
      "reference_id": "MONDO:0024504"
    }
  ],
  "roots": [
    {
      "id": 7051,
      "label": "carcinoid tumor"
    },
    {
      "id": 19671,
      "label": "pancreatic neuroendocrine tumor"
    }
  ]
}