{
  "id": 20678,
  "label": "connective tissue neoplasm",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0021581",
  "properties": {
    "xrefs": [
      "ICD9:239.2",
      "MEDGEN:45035",
      "MESH:D009372",
      "SCTID:126598008",
      "UMLS:C0027656"
    ],
    "synonyms": [
      "connective tissue neoplasm",
      "connective tissue neoplasm (disease)",
      "connective tissue tumor",
      "connective tissue tumour",
      "neoplasm of connective tissue",
      "neoplasm of connective tissues",
      "tumor of connective tissue",
      "tumour of connective tissue",
      "connective tissue neoplasms",
      "neoplasm, connective tissue"
    ],
    "categories": [
      {
        "ref": "MONDO:0003900",
        "name": "connective tissue disorder"
      }
    ],
    "definition": "Neoplasms composed of connective tissue, including elastic, mucous, reticular, osseous, and cartilaginous tissue. The concept does not refer to neoplasms located in connective tissue."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 13,
  "parents": [
    {
      "id": 5762,
      "label": "connective tissue disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29379
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:65",
          "EFO:1001986",
          "MEDGEN:1098",
          "MESH:D003240",
          "NANDO:2100172",
          "NCIT:C26729",
          "SCTID:105969002",
          "UMLS:C0009782"
        ],
        "synonyms": [
          "connective tissue disease",
          "connective tissue disease or disorder",
          "connective tissue diseases",
          "connective tissue disorder",
          "connective tissue disorders",
          "disease of connective tissue",
          "disease or disorder of connective tissue",
          "disease, connective tissue",
          "disorder of connective tissue",
          "primary disorder of connective tissue",
          "tissue disease, connective"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A disease involving the connective tissue."
      },
      "child_count": 16,
      "reference_id": "MONDO:0003900"
    },
    {
      "id": 6798,
      "label": "neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        21214
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:14566",
          "EFO:0000616",
          "HP:0002664",
          "ICD10CM:C00-D49",
          "ICD10CM:C7A-C7A",
          "ICD10CM:C7B-C7B",
          "ICD9:140-239",
          "ICD9:239.8",
          "ICD9:239.9",
          "MEDGEN:10294",
          "MESH:D009369",
          "NCIT:C3262",
          "ONCOTREE:OTHER",
          "SCTID:55342001",
          "UMLS:C0027651"
        ],
        "synonyms": [
          "cell process disease",
          "disease of cellular proliferation",
          "neoplasia",
          "neoplasm",
          "neoplasm (disease)",
          "neoplastic disease",
          "neoplastic growth",
          "tumor",
          "tumor disease",
          "tumour",
          "tumour disease",
          "other neoplasm"
        ],
        "definition": "A benign or malignant tissue growth resulting from uncontrolled cell proliferation. Benign neoplastic cells resemble normal cells without exhibiting significant cytologic atypia, while malignant cells exhibit overt signs such as dysplastic features, atypical mitotic figures, necrosis, nuclear pleomorphism, and anaplasia. Representative examples of benign neoplasms include papillomas, cystadenomas, and lipomas; malignant neoplasms include carcinomas, sarcomas, lymphomas, and leukemias."
      },
      "child_count": 48,
      "reference_id": "MONDO:0005070"
    }
  ],
  "children": [
    {
      "id": 3042,
      "label": "cartilage cancer",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3041,
        6893,
        20678
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060102",
          "GARD:0006004",
          "MEDGEN:1843449",
          "UMLS:C4290064"
        ],
        "synonyms": [
          "cancer of cartilage tissue",
          "cartilage tissue cancer",
          "cartilaginous cancer",
          "malignant cartilage tissue neoplasm",
          "malignant neoplasm of cartilage tissue"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A cancer involving a cartilage tissue."
      },
      "child_count": 0,
      "reference_id": "MONDO:0000639"
    },
    {
      "id": 4459,
      "label": "chondroma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3040,
        6893,
        20678,
        21426
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2602",
          "ICDO:9220/0",
          "MEDGEN:181701",
          "MESH:D002812",
          "NCIT:C53459",
          "UMLS:C0936248"
        ],
        "synonyms": [
          "chondroma",
          "chondroma, benign"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A benign well circumscribed neoplasm of hyaline cartilage arising from bone or soft tissue. It is characterized by the presence of chondrocytes."
      },
      "child_count": 12,
      "reference_id": "MONDO:0002360"
    },
    {
      "id": 4592,
      "label": "tenosynovial giant cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4297,
        4597,
        20678,
        21600
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:314",
          "EFO:1000562",
          "ICD9:727.89",
          "ICDO:9252/0",
          "MEDGEN:232927",
          "NCIT:C3402",
          "SCTID:310605004",
          "UMLS:C1318543"
        ],
        "synonyms": [
          "fibrous histiocytoma of tendon sheath",
          "giant cell neoplasm of Tenosynovium",
          "giant cell neoplasm of tendon sheath",
          "giant cell neoplasm of the Tenosynovium",
          "giant cell tumor of Tenosynovium",
          "giant cell tumor of tendon sheath",
          "giant cell tumor of the Tenosynovium",
          "giant cell tumour of the Tenosynovium",
          "tendon sheath giant cell neoplasm",
          "tendon sheath giant cell tumor",
          "tendon sheath giant cell tumour",
          "tenosynovial giant cell neoplasm",
          "tenosynovial giant cell tumor"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A tumor usually arising in the synovium of joints, bursa or tendon sheath. It is characterized by the presence of mononuclear cells, multinucleated osteoclast-like giant cells, hemosiderin-laden macrophages, foam cells, and an inflammatory infiltrate. According to the growth pattern, it is classified as localized or diffuse."
      },
      "child_count": 12,
      "reference_id": "MONDO:0002522"
    },
    {
      "id": 5242,
      "label": "dartoic leiomyoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5232,
        20678
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5147",
          "GARD:0023436",
          "ICD9:215.9",
          "MEDGEN:91078",
          "NCIT:C4483",
          "SCTID:254770007",
          "UMLS:C0346066"
        ],
        "synonyms": [
          "dartoic leiomyoma",
          "dartoic myoma",
          "dartos muscle leiomyoma",
          "leiomyoma of dartos muscle"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A cutaneous leiomyoma arising from the dartos muscle of the scrotum or labia majora."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003301"
    },
    {
      "id": 6131,
      "label": "cholangiolocellular carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5166,
        20678
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7642",
          "GARD:0023929",
          "MEDGEN:273143",
          "NCIT:C41617",
          "UMLS:C1516490"
        ],
        "synonyms": [
          "CLC",
          "cholangiocarcinoma of intralobular bile duct",
          "cholangiolocellular carcinoma",
          "intralobular bile duct cholangiocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An intrahepatic cholangiocarcinoma that arises from the canals of Hering."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004315"
    },
    {
      "id": 7547,
      "label": "scirrhous adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6712,
        20678
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4024",
          "EFO:0007478",
          "ICDO:8141/3",
          "MEDGEN:2873",
          "MESH:D002293",
          "NCIT:C2928",
          "UMLS:C0007135"
        ],
        "synonyms": [
          "FIBROADENOCARCINOMA, malignant",
          "adenocarcinoma with productive fibrosis",
          "fibrocarcinoma",
          "scirrhous adenocarcinoma",
          "scirrhous adenocarcinoma (morphologic abnormality)",
          "scirrhous carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "An infiltrating adenocarcinoma characterized by the presence of desmoplastic stromal reaction."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005953"
    },
    {
      "id": 7661,
      "label": "angiomyxoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        20678,
        23337
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000087",
          "ICD9:215.9",
          "ICDO:8841/0",
          "ICDO:8841/1",
          "MEDGEN:1790210",
          "NCIT:C3254",
          "SCTID:404083008",
          "UMLS:C5551004"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A benign soft tissue neoplasm characterized by the presence of neoplastic spindle and stellate cells, and vascular proliferation in a myxoid stroma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006086"
    },
    {
      "id": 7762,
      "label": "fibroblastic neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4667,
        20678
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000255",
          "MEDGEN:60198",
          "NCIT:C7075",
          "UMLS:C0206643"
        ],
        "synonyms": [
          "fibroblastic neoplasm",
          "fibroblastic tumor",
          "fibroblastic tumour",
          "fibrocytic neoplasm",
          "fibrocytic tumor",
          "fibrocytic tumour",
          "fibrogenic neoplasm",
          "fibrogenicTumor",
          "fibrous neoplasm",
          "fibrous tumor",
          "fibrous tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A benign, intermediate, or malignant mesenchymal neoplasm characterized by the presence of neoplastic fibroblasts."
      },
      "child_count": 14,
      "reference_id": "MONDO:0006209"
    },
    {
      "id": 10235,
      "label": "chondrosarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6816,
        20678,
        21247
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3371",
          "EFO:0000333",
          "GARD:0006055",
          "HP:0006765",
          "ICD9:170.9",
          "ICDO:9220/3",
          "MEDGEN:3054",
          "MESH:D002813",
          "MedDRA:10008734",
          "NANDO:2200050",
          "NCIT:C2946",
          "OMIM:215300",
          "ONCOTREE:CHS",
          "Orphanet:55880",
          "SCTID:443520009",
          "UMLS:C0008479"
        ],
        "synonyms": [
          "chondrosarcoma",
          "chondrosarcoma (disease)",
          "chondrosarcoma, malignant",
          "chondrosarcoma, somatic mutation",
          "chondrosarcoma of bone",
          "primary chondrosarcoma of the bone"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A malignant cartilaginous matrix-producing mesenchymal neoplasm arising from the bone and soft tissue. It usually affects middle-aged to elderly adults. The pelvic bones, ribs, shoulder girdle, and long bones are the most common sites of involvement. Most chondrosarcomas arise de novo, but some may develop in a preexisting benign cartilaginous lesion."
      },
      "child_count": 12,
      "reference_id": "MONDO:0008977"
    },
    {
      "id": 18958,
      "label": "bone neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7061,
        20678
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0003820",
          "GARD:0018892",
          "ICD10CM:C40-C41",
          "MEDGEN:488993",
          "NCIT:C9343",
          "ONCOTREE:BONE",
          "Orphanet:68411",
          "UMLS:C2732838"
        ],
        "synonyms": [
          "bone neoplasm",
          "bone neoplasms",
          "bone tissue neoplasm",
          "bone tissue tumor",
          "bone tissue tumour",
          "bone tumor",
          "bone tumors",
          "bone tumour",
          "bone tumours",
          "neoplasm of bone",
          "neoplasm of bone tissue",
          "neoplasm of the bone",
          "osseous neoplasm",
          "osseous tumor",
          "osseous tumour",
          "tumor of bone",
          "tumor of bone tissue",
          "tumor of the bone",
          "tumour of bone",
          "tumour of bone tissue",
          "tumour of the bone",
          "primary bone cancer",
          "primary malignant neoplasm of bone",
          "rare bone tumor",
          "rare bone tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A benign, intermediate, or malignant neoplasm involving the bone or articular cartilage."
      },
      "child_count": 40,
      "reference_id": "MONDO:0019060"
    },
    {
      "id": 20521,
      "label": "tumor of adipose tissue",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4667,
        20678
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD9:239.2",
          "MEDGEN:61646",
          "NCIT:C4248",
          "SCTID:254831005",
          "UMLS:C0206631"
        ],
        "synonyms": [
          "adipose tissue neoplasm",
          "adipose tissue neoplasm (disease)",
          "adipose tissue tumor",
          "adipose tissue tumour",
          "lipomatous neoplasm",
          "lipomatous tumor",
          "lipomatous tumour",
          "neoplasm of adipose tissue",
          "neoplasm of the adipose tissue",
          "tumor of adipose tissue",
          "tumor of the adipose tissue",
          "tumour of the adipose tissue"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A neoplasm (disease) that involves the adipose tissue."
      },
      "child_count": 6,
      "reference_id": "MONDO:0021354"
    },
    {
      "id": 25578,
      "label": "lipofibromatosis-like neural tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        20678
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080894"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A connective tissue cancer that has material basis in LMNA-NTRK1 gene fusion."
      },
      "child_count": 0,
      "reference_id": "MONDO:0956985"
    },
    {
      "id": 25579,
      "label": "solitary fibrous tumor/hemangiopericytoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        20678
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080897"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A connective tissue cancer that is characterized as the combination of solitary fibrous tumors and hemangiopericytomas."
      },
      "child_count": 0,
      "reference_id": "MONDO:0956986"
    }
  ],
  "roots": [
    {
      "id": 5762,
      "label": "connective tissue disorder"
    },
    {
      "id": 6798,
      "label": "neoplasm"
    }
  ]
}