{
  "id": 20692,
  "label": "astrocytic tumor",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0021636",
  "properties": {
    "xrefs": [
      "DOID:3069",
      "GARD:0012928",
      "MedDRA:10003571",
      "NCIT:C6958",
      "Orphanet:94"
    ],
    "synonyms": [
      "astrocytic neoplasm",
      "astrocytic tumor",
      "astrocytoma, no ICD-O subtype",
      "astroglioma",
      "astrocytoma",
      "astrocytoma of cerebrum"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "A glial tumor of the brain or spinal cord showing astrocytic differentiation. It includes the following clinicopathological entities: pilocytic astrocytoma, diffuse astrocytoma, anaplastic astrocytoma, pleomorphic xanthoastrocytoma, subependymal giant cell astrocytoma, and glioblastoma."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 8,
  "parents": [
    {
      "id": 20287,
      "label": "glioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20418
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0005543",
          "GARD:0006513",
          "MEDGEN:9030",
          "MESH:D005910",
          "NCIT:C3059",
          "Orphanet:182067",
          "SCTID:393564001",
          "UMLS:C0017638"
        ],
        "synonyms": [
          "glial neoplasm",
          "glial tumor",
          "glial tumour",
          "glioma",
          "neoplasm of neuroglia",
          "neoplasm of the neuroglia",
          "neuroglial neoplasm",
          "neuroglial tumor",
          "neuroglial tumour",
          "tumor of neuroglia",
          "tumor of the neuroglia",
          "tumour of neuroglia",
          "tumour of the neuroglia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A benign or malignant brain and spinal cord tumor that arises from glial cells (astrocytes, oligodendrocytes, ependymal cells). Tumors that arise from astrocytes are called astrocytic tumors or astrocytomas. Tumors that arise from oligodendrocytes are called oligodendroglial tumors. Tumors that arise from ependymal cells are called ependymomas."
      },
      "child_count": 9,
      "reference_id": "MONDO:0021042"
    }
  ],
  "children": [
    {
      "id": 4577,
      "label": "adult astrocytic tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20692
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3076",
          "GARD:0023151",
          "MEDGEN:272290",
          "NCIT:C7049",
          "UMLS:C1332183"
        ],
        "synonyms": [
          "astrocytic tumor",
          "astrocytic tumour",
          "adult astrocytic neoplasm",
          "adult astrocytic tumor"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An astrocytic tumor occurring during adulthood. Representative examples include diffuse astrocytoma, anaplastic astrocytoma, and glioblastoma."
      },
      "child_count": 2,
      "reference_id": "MONDO:0002503"
    },
    {
      "id": 4578,
      "label": "childhood astrocytic tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20320,
        20692
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3079",
          "GARD:0023152",
          "MEDGEN:272112",
          "NCIT:C9022",
          "UMLS:C1321865"
        ],
        "synonyms": [
          "astrocytic tumor",
          "astrocytic tumour",
          "astrocytic tumor of childhood",
          "astrocytic tumors, childhood",
          "astrocytic tumour of childhood",
          "childhood astrocytic neoplasm",
          "childhood astrocytic tumor",
          "juvenile astrocytoma",
          "juvenile astrocytoma (morphologic abnormality)",
          "paediatric astrocytic neoplasm",
          "paediatric astrocytic tumour",
          "paediatric astrocytoma",
          "pediatric astrocytic neoplasm",
          "pediatric astrocytic tumor"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An astrocytic tumor appearing before the age of twenty one without designation of benign or malignant nor designated location."
      },
      "child_count": 8,
      "reference_id": "MONDO:0002505"
    },
    {
      "id": 5134,
      "label": "gliofibroma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        20692
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4856",
          "GARD:0023394",
          "ICDO:9442/1",
          "MEDGEN:226850",
          "NCIT:C5419",
          "UMLS:C1266178"
        ],
        "synonyms": [
          "gliofibroma (morphologic abnormality)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An astrocytic tumor affecting young people. Morphologically, it is characterized by the presence of collagenous tissue surrounding neoplastic astrocytes. In some cases the collagen is produced by the tumor cells (desmoplastic astrocytoma), whereas in others it is produced by mesenchymal cells (mixed glioma/fibroma)."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003170"
    },
    {
      "id": 17144,
      "label": "high grade astrocytic tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20692,
        24071
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020704",
          "MEDGEN:769639",
          "NCIT:C102897",
          "Orphanet:251561",
          "UMLS:C3640999"
        ],
        "synonyms": [
          "high grade astrocytic neoplasm",
          "high grade astrocytic tumor",
          "high-grade astrocytic neoplasm",
          "high-grade astrocytic tumor",
          "high-grade astrocytic tumour",
          "high-grade astrocytoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An anaplastic astrocytoma (grade III astrocytic tumor) or glioblastoma (grade IV astrocytic tumor)."
      },
      "child_count": 6,
      "reference_id": "MONDO:0016680"
    },
    {
      "id": 19525,
      "label": "astrocytoma (excluding glioblastoma)",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20692
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0000272",
          "GARD:0025146",
          "ICDO:9400/3",
          "MEDGEN:438",
          "MESH:D001254",
          "NCIT:C60781",
          "ONCOTREE:ASTR",
          "SCTID:147101000119108",
          "UMLS:C0004114"
        ],
        "synonyms": [
          "astrocytoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A tumor of the brain or spinal cord showing astrocytic differentiation. It includes the following clinicopathological entities: pilocytic astrocytoma, diffuse astrocytoma, anaplastic astrocytoma, pleomorphic xanthoastrocytoma, and subependymal giant cell astrocytoma."
      },
      "child_count": 5,
      "reference_id": "MONDO:0019781"
    },
    {
      "id": 20694,
      "label": "low grade astrocytic tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20692,
        20693
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025344",
          "NCIT:C116342"
        ],
        "synonyms": [
          "low grade astrocytic neoplasm",
          "low grade astrocytic tumor",
          "low-grade astrocytic neoplasm",
          "low-grade astrocytic tumor",
          "low-grade astrocytic tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A grade I or grade II astrocytic tumor. This category includes pilocytic astrocytoma (grade I), subependymal giant cell astrocytoma (grade I), and diffuse astrocytoma (grade II)."
      },
      "child_count": 2,
      "reference_id": "MONDO:0021638"
    },
    {
      "id": 25200,
      "label": "anaplastic pleomorphic xanthoastrocytoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20692
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080854",
          "GARD:0013624",
          "MEDGEN:924393",
          "NCIT:C129327",
          "UMLS:C4283858"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A malignant astrocytoma that is characterized by the presence of five or more mitoses per 10 high-power fields."
      },
      "child_count": 1,
      "reference_id": "MONDO:0850312"
    },
    {
      "id": 25254,
      "label": "infant-type hemispheric glioma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        20692
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0081278",
          "GARD:0026636",
          "MEDGEN:1806401",
          "NCIT:C185471",
          "Orphanet:695136",
          "UMLS:C5669919"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A malignant astrocytoma that is characterized by receptor tyrosine kinase fusions in the NTRK family, ROS1, ALK, or MET genes, that arises in the cerebral hemisphere and occurs in early childhood."
      },
      "child_count": 0,
      "reference_id": "MONDO:0858940"
    }
  ],
  "roots": [
    {
      "id": 20287,
      "label": "glioma"
    }
  ]
}