{
  "id": 20693,
  "label": "low grade glioma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0021637",
  "properties": {
    "xrefs": [
      "DOID:0060101",
      "DOID:0080829",
      "GARD:0025343",
      "MEDGEN:744283",
      "NCIT:C132067",
      "UMLS:C1997217"
    ],
    "synonyms": [
      "benign glioma",
      "glioma, benign",
      "low grade glioma",
      "low-grade glioma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "A grade I or grade II glioma arising from the central nervous system. This category includes pilocytic astrocytoma, diffuse astrocytoma, subependymal giant cell astrocytoma, ependymoma, oligodendroglioma, oligoastrocytoma, and angiocentric glioma."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 6,
  "parents": [
    {
      "id": 20287,
      "label": "glioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20418
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0005543",
          "GARD:0006513",
          "MEDGEN:9030",
          "MESH:D005910",
          "NCIT:C3059",
          "Orphanet:182067",
          "SCTID:393564001",
          "UMLS:C0017638"
        ],
        "synonyms": [
          "glial neoplasm",
          "glial tumor",
          "glial tumour",
          "glioma",
          "neoplasm of neuroglia",
          "neoplasm of the neuroglia",
          "neuroglial neoplasm",
          "neuroglial tumor",
          "neuroglial tumour",
          "tumor of neuroglia",
          "tumor of the neuroglia",
          "tumour of neuroglia",
          "tumour of the neuroglia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A benign or malignant brain and spinal cord tumor that arises from glial cells (astrocytes, oligodendrocytes, ependymal cells). Tumors that arise from astrocytes are called astrocytic tumors or astrocytomas. Tumors that arise from oligodendrocytes are called oligodendroglial tumors. Tumors that arise from ependymal cells are called ependymomas."
      },
      "child_count": 9,
      "reference_id": "MONDO:0021042"
    }
  ],
  "children": [
    {
      "id": 4612,
      "label": "schwannoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4613,
        17200,
        20693
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3192",
          "DOID:955",
          "EFO:0000693",
          "GARD:0004767",
          "ICD9:215.9",
          "ICDO:9560/0",
          "MEDGEN:45053",
          "MedDRA:10029234",
          "MedDRA:10029235",
          "NANDO:2200103",
          "NCIT:C3269",
          "ONCOTREE:SCHW",
          "Orphanet:252164",
          "SCTID:404022001",
          "UMLS:C0027809",
          "icd11.foundation:378766741"
        ],
        "synonyms": [
          "benign neurilemmoma",
          "benign schwannoma",
          "neurilemmoma",
          "neurinoma",
          "peripheral fibroblastoma",
          "schwannoma",
          "schwannoma (WHO grade I)",
          "schwannoma, benign",
          "SCHW",
          "neurolemmoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A benign, usually encapsulated slow growing tumor composed of Schwann cells. It affects peripheral and cranial nerves. It recurs infrequently and only rare cases associated with malignant transformation have been reported."
      },
      "child_count": 30,
      "reference_id": "MONDO:0002546"
    },
    {
      "id": 17166,
      "label": "angiocentric glioma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        20693
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0081261",
          "GARD:0020714",
          "ICDO:9431/1",
          "MEDGEN:453267",
          "NCIT:C92552",
          "ONCOTREE:ANGL",
          "Orphanet:251671",
          "UMLS:C2363903"
        ],
        "synonyms": [
          "Monomorphus angiocentric glioma",
          "angiocentric glioma (WHO grade I)",
          "angiocentric neuroepithelial tumor",
          "angiocentric neuroepithelial tumour",
          "ANGL"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Angiocentric glioma (AG) is an extremely rare slow-growing glial neoplasm of the central nervous system, usually arising in a superficial location in the cerebrum, affecting all ages and both sexes, and characterized by intractable seizures and headaches, with most cases being cured by surgical incision alone and therefore having a good prognosis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016705"
    },
    {
      "id": 20694,
      "label": "low grade astrocytic tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20692,
        20693
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025344",
          "NCIT:C116342"
        ],
        "synonyms": [
          "low grade astrocytic neoplasm",
          "low grade astrocytic tumor",
          "low-grade astrocytic neoplasm",
          "low-grade astrocytic tumor",
          "low-grade astrocytic tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A grade I or grade II astrocytic tumor. This category includes pilocytic astrocytoma (grade I), subependymal giant cell astrocytoma (grade I), and diffuse astrocytoma (grade II)."
      },
      "child_count": 2,
      "reference_id": "MONDO:0021638"
    },
    {
      "id": 20695,
      "label": "grade II glioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20693
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025345",
          "MEDGEN:1391502",
          "NCIT:C132505",
          "UMLS:C4330050"
        ],
        "synonyms": [
          "WHO grade II glioma",
          "grade II glioma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A glioma arising from the central nervous system. This category includes diffuse astrocytoma, ependymoma, oligodendroglioma, and oligoastrocytoma."
      },
      "child_count": 5,
      "reference_id": "MONDO:0021639"
    },
    {
      "id": 25548,
      "label": "childhood low-grade glioma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        20693
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080830",
          "GARD:0026753",
          "MEDGEN:1861125",
          "NCIT:C202299",
          "UMLS:C5908420"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A low-grade glioma that occurs in children and encompasses tumors of astrocytic, oligodendroglial, and mixed glial-neuronal histology."
      },
      "child_count": 0,
      "reference_id": "MONDO:0859591"
    },
    {
      "id": 25552,
      "label": "diffuse low-grade glioma, MAPK pathway–altered",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        20693
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0081260",
          "GARD:0026757",
          "NCIT:C185218"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A low grade glioma that is characterized by a gene alteration that results in a MAPK pathway abnormality, with morphological features of astrocytoma or oligodendroglioma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0859614"
    }
  ],
  "roots": [
    {
      "id": 20287,
      "label": "glioma"
    }
  ]
}