{
  "id": 20695,
  "label": "grade II glioma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0021639",
  "properties": {
    "xrefs": [
      "GARD:0025345",
      "MEDGEN:1391502",
      "NCIT:C132505",
      "UMLS:C4330050"
    ],
    "synonyms": [
      "WHO grade II glioma",
      "grade II glioma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "A glioma arising from the central nervous system. This category includes diffuse astrocytoma, ependymoma, oligodendroglioma, and oligoastrocytoma."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 5,
  "parents": [
    {
      "id": 20693,
      "label": "low grade glioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20287
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060101",
          "DOID:0080829",
          "GARD:0025343",
          "MEDGEN:744283",
          "NCIT:C132067",
          "UMLS:C1997217"
        ],
        "synonyms": [
          "benign glioma",
          "glioma, benign",
          "low grade glioma",
          "low-grade glioma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A grade I or grade II glioma arising from the central nervous system. This category includes pilocytic astrocytoma, diffuse astrocytoma, subependymal giant cell astrocytoma, ependymoma, oligodendroglioma, oligoastrocytoma, and angiocentric glioma."
      },
      "child_count": 6,
      "reference_id": "MONDO:0021637"
    }
  ],
  "children": [
    {
      "id": 17150,
      "label": "diffuse astrocytoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        17149,
        20695
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4857",
          "GARD:0005907",
          "MEDGEN:83708",
          "NANDO:2200085",
          "NCIT:C7173",
          "ONCOTREE:DASTR",
          "Orphanet:251595",
          "UMLS:C0280785"
        ],
        "synonyms": [
          "WHO grade II astrocytoma",
          "astrocytoma, diffuse",
          "astrocytoma, diffuse, malignant",
          "diffuse astrocytoma",
          "grade II astrocytic neoplasm",
          "grade II astrocytic tumor",
          "grade II astrocytic tumour",
          "grade II astrocytoma",
          "fibrillary astrocytoma (histologic variant)",
          "gemistocytic astrocytoma (histologic variant)",
          "low-grade diffuse astrocytoma",
          "protoplasmic astrocytoma (histologic variant)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A low-grade (WHO grade II) astrocytic neoplasm. It is characterized by diffuse infiltration of neighboring central nervous system structures. These lesions typically affect young adults and have a tendency for progression to anaplastic astrocytoma and glioblastoma. Based on the IDH genes mutation status, diffuse astrocytomas are classified as IDH-mutant, IDH-wildtype, and not otherwise specified."
      },
      "child_count": 8,
      "reference_id": "MONDO:0016686"
    },
    {
      "id": 17158,
      "label": "oligodendroglioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        18713,
        20695
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3181",
          "EFO:0000632",
          "GARD:0009953",
          "ICDO:9450/3",
          "MEDGEN:45190",
          "MESH:D009837",
          "MedDRA:10030286",
          "NANDO:2200089",
          "NCIT:C3288",
          "ONCOTREE:ODG",
          "Orphanet:251627",
          "UMLS:C0028945"
        ],
        "synonyms": [
          "oligodendroglial neoplasm",
          "oligodendroglial tumor",
          "oligodendroglial tumour",
          "WHO grade II oligodendroglial neoplasm",
          "WHO grade II oligodendroglial tumor",
          "WHO grade II oligodendroglial tumour",
          "oligodendroglioma",
          "well differentiated oligodendroglial tumor",
          "well differentiated oligodendroglial tumour",
          "well differentiated oligodendroglioma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A well-differentiated (WHO grade II), diffusely infiltrating neuroglial tumor, typically located in the cerebral hemispheres. It is composed predominantly of cells which morphologically resemble oligodendroglia. The neoplastic cells have rounded homogeneous nuclei and, on paraffin sections, a swollen, clear cytoplasm ('honeycomb' appearance). (Adapted from WHO)"
      },
      "child_count": 8,
      "reference_id": "MONDO:0016695"
    },
    {
      "id": 17161,
      "label": "ependymoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5210,
        20695
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4844",
          "EFO:1000028",
          "GARD:0006353",
          "ICDO:9391/3",
          "MEDGEN:41825",
          "MESH:D004806",
          "MedDRA:10014967",
          "NANDO:2200088",
          "NCIT:C3017",
          "ONCOTREE:EPM",
          "Orphanet:251636",
          "UMLS:C0014474"
        ],
        "synonyms": [
          "benign ependymoma",
          "ependymoma",
          "WHO grade II ependymal neoplasm",
          "WHO grade II ependymal tumor",
          "WHO grade II ependymal tumour",
          "ependymoma, benign",
          "clear cell ependymoma (histologic variant)",
          "ependymoma, familial",
          "papillary ependymoma (histologic variant)",
          "tanycytic ependymoma (histologic variant)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A WHO grade II, slow growing tumor of children and young adults, usually located intraventricularly. It is the most common ependymal neoplasm. It often causes clinical symptoms by blocking cerebrospinal fluid pathways. Key histological features include perivascular pseudorosettes and ependymal rosettes. (WHO)"
      },
      "child_count": 16,
      "reference_id": "MONDO:0016698"
    },
    {
      "id": 17164,
      "label": "oligoastrocytoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5211,
        20695
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7912",
          "EFO:0000630",
          "GARD:0009769",
          "MEDGEN:154285",
          "MedDRA:10027744",
          "NCIT:C4050",
          "ONCOTREE:OAST",
          "Orphanet:251656",
          "SCTID:716647001",
          "UMLS:C0547065"
        ],
        "synonyms": [
          "MOA",
          "WHO grade II mixed glioma",
          "glioma, mixed, benign",
          "mixed astrocytic-oligodendroglial neoplasm",
          "mixed astrocytic-oligodendroglial tumor",
          "mixed astrocytic-oligodendroglial tumour",
          "mixed astrocytoma-oligodendroglioma",
          "mixed oligo-astrocytoma",
          "mixed oligoastrocytoma",
          "mixed oligodendroglioma-astrocytoma",
          "oligoastrocytoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A WHO grade II tumor composed of a conspicuous mixture of two distinct neoplastic cell types morphologically resembling the tumor cells in oligodendroglioma and diffuse astrocytoma. (WHO)"
      },
      "child_count": 2,
      "reference_id": "MONDO:0016702"
    },
    {
      "id": 17167,
      "label": "chordoid glioma of the third ventricle",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4729,
        4814,
        7155,
        20695
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3773",
          "DOID:3774",
          "GARD:0020715",
          "ICDO:9444/1",
          "MEDGEN:232956",
          "NCIT:C5592",
          "ONCOTREE:CHGL",
          "Orphanet:251674",
          "SCTID:715900001",
          "UMLS:C1322252"
        ],
        "synonyms": [
          "chordoid glioma",
          "chordoid glioma (morphologic abnormality)",
          "chordoid glioma of 3rd ventricle",
          "chordoid glioma of the 3rd ventricle",
          "chordoid glioma of the third ventricle",
          "chordoid glioma of the third ventricle (WHO grade II)",
          "chordoid glioma of third ventricle",
          "third ventricle chordoid glioma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A rare, slow-growing neuroepithelial neoplasm of uncertain origin affecting adults. It is located in the third ventricle. It is characterized by the presence of epithelioid cells which express GFAP, and mucinous stroma which contains lymphoplasmacytic infiltrates."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016706"
    }
  ],
  "roots": [
    {
      "id": 20693,
      "label": "low grade glioma"
    }
  ]
}