{
  "id": 20696,
  "label": "grade III glioma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0021640",
  "properties": {
    "xrefs": [
      "GARD:0025346",
      "MEDGEN:925529",
      "NCIT:C127816",
      "UMLS:C4287997"
    ],
    "synonyms": [
      "WHO grade III glioma",
      "anaplastic glioma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "A group of malignant gliomas that includes anaplastic astrocytoma, anaplastic oligodendroglioma, anaplastic oligoastrocytoma, and anaplastic ependymoma."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 24071,
      "label": "malignant glioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4753,
        20078,
        20287
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3070",
          "GARD:0026148",
          "ICDO:9380/3",
          "MEDGEN:107826",
          "MedDRA:10018338",
          "NCIT:C4822",
          "UMLS:C0555198"
        ],
        "synonyms": [
          "glioma",
          "neuroglial tumor",
          "neuroglial tumour",
          "glial cell tumour",
          "glioma, malignant",
          "high grade glioma",
          "high-grade glioma",
          "malignant glial neoplasm",
          "malignant glial tumor",
          "malignant glial tumour",
          "malignant glioma",
          "malignant neuroglial neoplasm",
          "malignant neuroglial tumor",
          "malignant neuroglial tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A grade III or grade IV glioma arising from the central nervous system. This category includes glioblastoma, anaplastic astrocytoma, anaplastic ependymoma, anaplastic oligodendroglioma, and anaplastic oligoastrocytoma."
      },
      "child_count": 36,
      "reference_id": "MONDO:0100342"
    }
  ],
  "children": [
    {
      "id": 17159,
      "label": "anaplastic oligodendroglioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        18713,
        20048,
        20696
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7154",
          "EFO:0002501",
          "GARD:0009472",
          "ICDO:9451/3",
          "MEDGEN:90812",
          "MedDRA:10026659",
          "NCIT:C4326",
          "ONCOTREE:AODG",
          "Orphanet:251630",
          "UMLS:C0334590"
        ],
        "synonyms": [
          "WHO grade III oligodendroglial neoplasm",
          "WHO grade III oligodendroglial tumor",
          "WHO grade III oligodendroglial tumour",
          "anaplastic oligodendroglioma",
          "malignant oligodendroglioma",
          "oligodendroglioma, anaplastic, malignant",
          "oligodendroglioma, malignant",
          "undifferentiated oligodendroglioma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A WHO grade III oligodendroglioma with focal or diffuse malignant morphologic features (prominent nuclear pleomorphism, mitoses, and increased cellularity)."
      },
      "child_count": 3,
      "reference_id": "MONDO:0016696"
    },
    {
      "id": 17163,
      "label": "anaplastic ependymoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5210,
        20048,
        20696
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5074",
          "DOID:5889",
          "GARD:0010634",
          "ICDO:9392/3",
          "MEDGEN:128891",
          "MedDRA:10014968",
          "NCIT:C4049",
          "ONCOTREE:APE",
          "Orphanet:251646",
          "UMLS:C0280788"
        ],
        "synonyms": [
          "ependymal tumors",
          "ependymal tumours",
          "WHO grade III ependymal neoplasm",
          "WHO grade III ependymal tumor",
          "WHO grade III ependymal tumour",
          "anaplastic ependymal neoplasm",
          "anaplastic ependymal tumor",
          "anaplastic ependymal tumour",
          "anaplastic ependymoma",
          "ependymoma, anaplastic, malignant",
          "ependymoma, malignant",
          "high-grade ependymoma",
          "malignant ependymoma",
          "undifferentiated ependymal neoplasm",
          "undifferentiated ependymal tumor",
          "undifferentiated ependymal tumour",
          "undifferentiated ependymoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Anaplastic ependymoma is a rare, malignant type of ependymoma that most often arises in the supratentorial region of the brain of children and young adults and that manifests with variable symptoms including headaches, nausea, vision impairment, memory loss and difficulty walking."
      },
      "child_count": 9,
      "reference_id": "MONDO:0016700"
    },
    {
      "id": 17165,
      "label": "anaplastic oligoastrocytoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7464,
        17164,
        20048,
        20696
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0002500",
          "GARD:0010637",
          "MEDGEN:96556",
          "NCIT:C6959",
          "ONCOTREE:AOAST",
          "Orphanet:251663",
          "UMLS:C0431108"
        ],
        "synonyms": [
          "WHO grade III mixed glioma",
          "aMOA",
          "anaplastic mixed glioma",
          "anaplastic oligoastrocytoma",
          "AOAST"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An oligoastrocytoma characterized by the presence of increased cellularity, nuclear atypia, pleomorphism, and high mitotic activity."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016703"
    }
  ],
  "roots": [
    {
      "id": 24071,
      "label": "malignant glioma"
    }
  ]
}