{
  "id": 21052,
  "label": "cryofibrinogenemia",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0022904",
  "properties": {
    "xrefs": [
      "ICD9:286.9",
      "MEDGEN:78798",
      "MESH:C536218",
      "SCTID:10934005",
      "UMLS:C0272263"
    ],
    "synonyms": [
      "cryofibrinogenemia"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      }
    ]
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 7222,
      "label": "cryoglobulinemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4539,
        8586
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2917",
          "EFO:0005846",
          "ICD10CM:D89.1",
          "ICD9:273.2",
          "MEDGEN:3673",
          "MESH:D003449",
          "NCIT:C26736",
          "SCTID:30911005",
          "UMLS:C0010403"
        ],
        "synonyms": [
          "cryoglobulinemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "Cryoglobulinemia is a type of vasculitis that is caused by abnormal proteins (antibodies) in the blood called 'cryoglobulins.' At cold temperatures, these proteins become solid or gel-like, which can block blood vessels and cause a variety of health problems. Many people affected by this condition will not experience any unusual signs or symptoms. When present, symptoms vary but may include breathing problems; fatigue; glomerulonephritis ; joint or muscle pain; purpura ; Raynaud's phenomenon ; skin death; and/or skin ulcers. In some cases, the exact underlying cause is unknown; however, cryoglobulinemia can be associated with a variety of conditions including certain types of infection; chronic inflammatory diseases (such as autoimmune disease); and/or cancers of the blood or immune system. Treatment varies based on the severity of the condition, the symptoms present in each person and the underlying cause."
      },
      "child_count": 2,
      "reference_id": "MONDO:0005576"
    }
  ],
  "children": [
    {
      "id": 8797,
      "label": "cryofibrinogenemia, familial primary",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5714,
        21052
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:377679",
          "MESH:C565142",
          "OMIM:123540",
          "UMLS:C1852457"
        ],
        "synonyms": [
          "cryofibrinogenemia, familial primary"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0007406"
    }
  ],
  "roots": [
    {
      "id": 7222,
      "label": "cryoglobulinemia"
    }
  ]
}