{
  "id": 21132,
  "label": "exogenous ochronosis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0023094",
  "properties": {
    "xrefs": [
      "GARD:0027910",
      "ICD9:270.2",
      "MEDGEN:1854236",
      "MESH:C531762",
      "SCTID:410041002",
      "UMLS:C5887145",
      "icd11.foundation:835922687"
    ],
    "synonyms": [
      "exogenous ochronosis",
      "ochronosis, acquired",
      "ocular ochronosis",
      "pseudo-ochronosis"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0003900",
        "name": "connective tissue disorder"
      }
    ],
    "definition": "Exogenous ochronosis refers tothe bluish-black discoloration of certain tissues, such as the ear cartilage, the ocular (eye) tissue, and other body locations when it is due toexposure to various substances.It has been reported most commonly with topical application of hydroquinones to the skin. The discolorationmay becaused byan effect ontyrosinase(an enzyme located in melanocytes, which are skincells that produce pigment), or by inhibiting homogentisic acid oxidase, resulting in the accumulation and deposition of homogentisic acid (HGA) in cartilage. The discoloration is often permanent, but when exogenous ochronosis is caused by topical hydroquinones, carbon dioxide lasers and dermabrasion have been reported to be helpful. Exogenous ochronosis is different from hereditary ochronosis, which is an inherited condition that occurs with alkaptonuria."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 4082,
      "label": "ochronosis disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5762,
        6795,
        6893
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:14223",
          "GARD:0007231",
          "HP:0030764",
          "ICD9:270.2",
          "MEDGEN:45177",
          "MESH:D009794",
          "NCIT:C84938",
          "SCTID:410042009",
          "UMLS:C0028817"
        ],
        "synonyms": [
          "ochronosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A disorder characterized by bluish-black discoloration of the cartilaginous tissues due to accumulation of homogentisic acid. It is associated with alkaptonuria. Signs and symptoms include dark urine, skin pigmentation, and arthritis."
      },
      "child_count": 3,
      "reference_id": "MONDO:0001910"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 4082,
      "label": "ochronosis disorder"
    }
  ]
}