{
  "id": 21182,
  "label": "functional pancreatic neuroendocrine tumor",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0023206",
  "properties": {
    "xrefs": [
      "GARD:0022053",
      "MEDGEN:310778",
      "NCIT:C45840",
      "Orphanet:506060",
      "UMLS:C1708107"
    ],
    "synonyms": [
      "functional pancreatic NET",
      "functional pancreatic neuroendocrine tumor",
      "functioning PNET",
      "functioning pancreatic NET",
      "functioning pancreatic endocrine tumor",
      "functioning pancreatic endocrine tumour",
      "functioning pancreatic neuroendocrine tumor",
      "functioning pancreatic neuroendocrine tumour",
      "functioning well differentiated pancreatic endocrine neoplasm",
      "functioning well differentiated pancreatic endocrine tumor",
      "functioning well differentiated pancreatic endocrine tumour",
      "functioning well-differentiated NEN of pancreas",
      "functioning well-differentiated neuroendocrine neoplasm of pancreas",
      "functioning well-differentiated pancreatic NEN",
      "functioning well-differentiated pancreatic neuroendocrine neoplasm",
      "syndromic pancreatic NET",
      "syndromic pancreatic neuroendocrine tumor",
      "syndromic pancreatic neuroendocrine tumour",
      "functioning neuroendocrine tumor of pancreas",
      "functioning neuroendocrine tumour of pancreas"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A low or intermediate grade well differentiated tumor with neuroendocrine differentiation that arises from the pancreas. It is characterized by the presence of a clinical syndrome that results from hormone hypersecretion."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 19671,
      "label": "pancreatic neuroendocrine tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2885,
        7431
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000045",
          "GARD:0013034",
          "ICDO:8150/1",
          "MEDGEN:277875",
          "NCIT:C27720",
          "ONCOTREE:PANET",
          "Orphanet:97253",
          "UMLS:C1337011"
        ],
        "synonyms": [
          "islet cell tumor",
          "islet cell tumors - pancreas",
          "islet cell tumors of the pancreas",
          "islet cell tumour",
          "islet cell tumours - pancreas",
          "islet cell tumours of the pancreas",
          "pancreatic NET",
          "pancreatic neuroendocrine tumor",
          "well differentiated pancreatic endocrine neoplasm",
          "well differentiated pancreatic endocrine tumor",
          "well differentiated pancreatic endocrine tumour",
          "well-differentiated NEN of pancreas",
          "well-differentiated neuroendocrine neoplasm of pancreas",
          "well-differentiated pancreatic NEN",
          "well-differentiated pancreatic neuroendocrine neoplasm",
          "PANET",
          "neuroendocrine tumor of pancreas",
          "neuroendocrine tumour of pancreas",
          "pancreatic endocrine tumor",
          "pancreatic endocrine tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Pancreatic endocrine tumor, also known as pancreatic neuroendocrine tumor (PNET), describes a group of endocrine tumors originating in the pancreas that are usually indolent and benign, but may have the potential to be malignant. They can be functional, exhibiting a hormonal hypersecretion syndrome, but can be non-functional presenting with non-specific symptoms and include insulinoma, glucagonoma, VIPoma, somatostatinoma (SSoma), PPoma and Zollinger-Ellison syndrome (ZES, or gastrinoma) and other ectopic hormone producing tumors (such as GRFoma)."
      },
      "child_count": 22,
      "reference_id": "MONDO:0019954"
    },
    {
      "id": 20359,
      "label": "functioning endocrine neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4223
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICDO:8158/1",
          "MEDGEN:458881",
          "NCIT:C94759",
          "UMLS:C2986655"
        ],
        "synonyms": [
          "functioning endocrine neoplasm",
          "functioning tumor",
          "functioning tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A hormone producing endocrine neoplasm, associated with a hormonal syndrome."
      },
      "child_count": 2,
      "reference_id": "MONDO:0021120"
    }
  ],
  "children": [
    {
      "id": 6149,
      "label": "pancreatic ACTH-producing neuroendocrine tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        21182
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7697",
          "GARD:0023943",
          "ICDO:8158/1",
          "MEDGEN:233302",
          "NCIT:C27466",
          "UMLS:C1335300"
        ],
        "synonyms": [
          "pancreatic ACTH producing NET",
          "pancreatic ACTH producing neuroendocrine tumor",
          "pancreatic ACTH producing neuroendocrine tumour",
          "pancreatic ACTH producing tumor",
          "pancreatic ACTH producing tumour",
          "pancreatic ACTH-producing neuroendocrine tumor",
          "pancreatic adrenocorticotropic hormone producing tumor",
          "pancreatic ACTH hormone producing tumor",
          "pancreatic ACTH hormone producing tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant, ectopic ACTH secreting pancreatic neuroendocrine tumor, associated with Cushing's syndrome. The prognosis is usually poor."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004333"
    },
    {
      "id": 21549,
      "label": "pancreatic gastrinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5436,
        21182
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025441",
          "MEDGEN:1849954",
          "NCIT:C95596",
          "UMLS:C5848106"
        ],
        "synonyms": [
          "pancreatic gastrinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A neuroendocrine tumor arising from the pancreas. It is characterized by inappropriate secretion of gastrin and associated with Zollinger Ellison syndrome. The latter is characterized by the presence of peptic ulcer, gastroesophageal reflux disease, abdominal pain, diarrhea, and malabsorption."
      },
      "child_count": 0,
      "reference_id": "MONDO:0024638"
    },
    {
      "id": 21578,
      "label": "pancreatic insulinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6780,
        21182
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3892",
          "GARD:0025458",
          "HP:0012197",
          "MEDGEN:43907",
          "MESH:D007340",
          "MedDRA:10022498",
          "NANDO:2200398",
          "NCIT:C95598",
          "SCTID:302822000",
          "UMLS:C0021670",
          "icd11.foundation:193813168"
        ],
        "synonyms": [
          "insulinoma",
          "pancreatic insulinoma",
          "Insulinomas",
          "Insulomas",
          "adenoma, beta cell",
          "adenoma, beta-cell",
          "adenomas, beta-cell",
          "beta cell tumor",
          "beta cell tumour",
          "beta-cell adenoma",
          "beta-cell adenomas",
          "beta-cell tumor",
          "beta-cell tumors",
          "beta-cell tumour",
          "beta-cell tumours",
          "insulin-producing tumour of islet cells",
          "insulinoma tumor suppressor GENE locus",
          "insulinoma tumour suppressor GENE locus",
          "insuloma",
          "islet cell adenoma",
          "tumor, beta-cell",
          "tumors, beta-cell"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An insulin-producing neuroendocrine tumor arising from the beta cells of the pancreas. Patients exhibit symptoms related to hypoglycemia due to inappropriate secretion of insulin."
      },
      "child_count": 0,
      "reference_id": "MONDO:0024677"
    }
  ],
  "roots": [
    {
      "id": 19671,
      "label": "pancreatic neuroendocrine tumor"
    },
    {
      "id": 20359,
      "label": "functioning endocrine neoplasm"
    }
  ]
}