{
  "id": 21206,
  "label": "ovarian granulosa cell tumor",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0023283",
  "properties": {
    "xrefs": [
      "GARD:0027911",
      "MEDGEN:277970",
      "MESH:C537296",
      "NCIT:C6261",
      "SCTID:254863004",
      "UMLS:C1370419"
    ],
    "synonyms": [
      "granulosa cell neoplasm of ovary",
      "granulosa cell neoplasm of the ovary",
      "granulosa cell tumor of ovary",
      "granulosa cell tumor of the ovary",
      "granulosa cell tumour of ovary",
      "granulosa cell tumour of the ovary",
      "ovarian granulosa cell neoplasm",
      "ovarian granulosa cell tumor",
      "ovary granulosa cell tumor",
      "ovary granulosa cell tumour",
      "GCT of the ovary",
      "adult granulosa cell tumor of the ovary",
      "adult granulosa cell tumour of the ovary",
      "granulosa theca cell tumor",
      "granulosa theca cell tumor of the ovary",
      "granulosa theca cell tumour",
      "granulosa theca cell tumour of the ovary"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A granulosa-stromal cell tumor that arises from the ovary. It is characterized by the presence of granulosa cells that comprise at least ten percent of the cellular population. The granulosa cells are often found in a background that contains theca and fibrous cells. There are two major subtypes recognized, adult and juvenile granulosa cell tumor. Clinically, patients may present with an abdominal mass. Symptoms depend on the patient's age. The most important indicator of prognosis is tumor stage. Age over forty years at the time of the initial diagnosis, large tumor size, bilaterality, cellular atypia, and increased mitotic activity are factors indicating a potentially aggressive clinical course and relative poor prognosis."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 7622,
      "label": "granulosa cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4223,
        7639
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2999",
          "EFO:1000032",
          "MEDGEN:6676",
          "MESH:D006106",
          "NCIT:C3070",
          "ONCOTREE:GRCT",
          "UMLS:C0018206"
        ],
        "synonyms": [
          "granulosa cell neoplasm",
          "granulosa cell neoplasm (disease)",
          "granulosa cell tumor",
          "granulosa cell tumor, adult type (morphologic abnormality)",
          "granulosa cell tumor, sarcomatoid",
          "neoplasm of granulosa cell",
          "tumor of granulosa cell",
          "tumour of granulosa cell",
          "GRCT",
          "granulosa cell tumor, undetermined"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A slow-growing, malignant tumor, characterize by the presence of granulosa-like cells and Call-Exner bodies, that is almost always found in the ovary. In rare cases, it has also been found in the testicle. There are two types of granulosa cell tumor that can be distinguished under the microscope: the adult and the juvenile. The testicular juvenile granulosa cell tumors are perhaps the most common congenital testicular neoplasms."
      },
      "child_count": 4,
      "reference_id": "MONDO:0006036"
    },
    {
      "id": 20709,
      "label": "ovarian sex cord-stromal tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7639,
        20309
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080369",
          "GARD:0012285",
          "MEDGEN:154644",
          "NCIT:C4862",
          "ONCOTREE:SCST",
          "UMLS:C0600113"
        ],
        "synonyms": [
          "Sex cord-stromal neoplasm of ovary",
          "Sex cord-stromal neoplasm of the ovary",
          "Sex cord-stromal tumor of ovary",
          "Sex cord-stromal tumor of the ovary",
          "Sex cord-stromal tumour of ovary",
          "Sex cord-stromal tumour of the ovary",
          "ovarian Sex cord-stromal neoplasm",
          "ovarian Sex cord-stromal tumor",
          "ovarian Sex cord-stromal tumour",
          "ovary sex cord-stromal tumor",
          "ovary sex cord-stromal tumour",
          "sex cord-stromal tumor of ovary",
          "sex cord-stromal tumour of ovary",
          "ovarian sex cord tumor with annular tubules",
          "ovarian sex cord tumour with annular tubules",
          "sex cord stromal tumor",
          "sex cord stromal tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign or malignant neoplasm that arises from the ovary and is composed of granulosa cells, Sertoli cells, Leydig cells, theca cells, and fibroblasts. Representative examples include thecoma, fibroma, Sertoli cell tumor, and granulosa cell tumor."
      },
      "child_count": 12,
      "reference_id": "MONDO:0021657"
    }
  ],
  "children": [
    {
      "id": 19985,
      "label": "maligant granulosa cell tumor of ovary",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18316,
        20310,
        21206
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019707",
          "MEDGEN:138043",
          "NCIT:C8403",
          "Orphanet:99915",
          "SCTID:254861002",
          "UMLS:C0346175",
          "icd11.foundation:148207042"
        ],
        "synonyms": [
          "adult ovarian granulosa cell tumor",
          "adult ovarian granulosa cell tumour",
          "cancer of granulosa cell",
          "granulosa cell cancer",
          "granulosa cell malignant tumor",
          "granulosa cell malignant tumour",
          "malignant granulosa cell neoplasm",
          "malignant granulosa cell neoplasm of ovary",
          "malignant granulosa cell neoplasm of the ovary",
          "malignant granulosa cell tumor of ovary",
          "malignant granulosa cell tumor of the ovary",
          "malignant granulosa cell tumour of ovary",
          "malignant granulosa cell tumour of the ovary",
          "malignant ovarian granulosa cell neoplasm",
          "malignant ovarian granulosa cell tumor",
          "malignant ovarian granulosa cell tumour",
          "ovarian granulosa cell tumor of adults",
          "ovarian granulosa cell tumour of adults",
          "GCT of the ovary",
          "GTCT",
          "Maligant granulosa cell tumor of the ovary",
          "Maligant granulosa cell tumour of the ovary",
          "adult granulosa cell tumor of the ovary",
          "adult granulosa cell tumour of the ovary",
          "granulosa theca cell tumor",
          "granulosa theca cell tumor of the ovary",
          "granulosa theca cell tumour",
          "granulosa theca cell tumour of the ovary"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An aggressive granulosa cell tumor that arises from the ovary and metastasizes to other anatomic sites."
      },
      "child_count": 0,
      "reference_id": "MONDO:0020541"
    }
  ],
  "roots": [
    {
      "id": 7622,
      "label": "granulosa cell tumor"
    },
    {
      "id": 20709,
      "label": "ovarian sex cord-stromal tumor"
    }
  ]
}