{
  "id": 21273,
  "label": "mediastinal yolk sac tumor",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0023726",
  "properties": {
    "xrefs": [
      "GARD:0008258",
      "MEDGEN:233176",
      "NCIT:C6443",
      "UMLS:C1334683"
    ],
    "synonyms": [
      "endodermal sinus neoplasm of mediastinum",
      "endodermal sinus neoplasm of the mediastinum",
      "endodermal sinus tumor of mediastinum",
      "endodermal sinus tumor of the mediastinum",
      "endodermal sinus tumour of mediastinum",
      "endodermal sinus tumour of the mediastinum",
      "mediastinal endodermal sinus neoplasm",
      "mediastinal endodermal sinus tumor",
      "mediastinal endodermal sinus tumour",
      "mediastinal yolk Sac neoplasm",
      "mediastinal yolk Sac tumor",
      "mediastinal yolk Sac tumour",
      "mediastinum yolk sac tumor",
      "mediastinum yolk sac tumour",
      "yolk Sac neoplasm of mediastinum",
      "yolk Sac neoplasm of the mediastinum",
      "yolk Sac tumor of mediastinum",
      "yolk Sac tumor of the mediastinum",
      "yolk Sac tumour of mediastinum",
      "yolk Sac tumour of the mediastinum",
      "EST",
      "mediastinal endodermal sinus tumors",
      "mediastinal endodermal sinus tumours"
    ],
    "definition": "An extragonadal non-seminomatous malignant germ cell tumor that arises from the mediastinum. It is characterized by the presence of small pale cells with small amount of cytoplasm and round to oval nuclei with small nucleoli forming a variety of patterns, including microcystic, macrocystic, pseudopapillary, myxomatous, hepatoid, polyvesicular vitelline, and solid. It manifests with respiratory distress, thoracic pain, fever, and superior vena cava syndrome."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 7365,
      "label": "yolk sac tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5475
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1911",
          "EFO:0007252",
          "GARD:0000348",
          "ICDO:9071/3",
          "MEDGEN:41782",
          "MedDRA:10048251",
          "NANDO:2200069",
          "NCIT:C3011",
          "ONCOTREE:BYST",
          "Orphanet:876",
          "SCTID:404081005",
          "UMLS:C0014145"
        ],
        "synonyms": [
          "endodermal sinus neoplasm",
          "endodermal sinus tumor",
          "hepatoid yolk sac tumor",
          "yolk SAC tumor, malignant",
          "yolk Sac neoplasm",
          "yolk Sac tumor",
          "yolk Sac tumor site unspecified",
          "yolk Sac tumour site unspecified",
          "yolk sac tumor",
          "infantile embryonal carcinoma"
        ],
        "definition": "A non-seminomatous malignant germ cell tumor composed of primitive germ cells. It is the most common malignant germ cell tumor in the pediatric population. It occurs in the infant testis, ovary, sacrococcygeal region, vagina, uterus, prostate, abdomen, liver, retroperitoneum, thorax, and pineal/third ventricle. The tumor mimics the yolk sac of the embryo and produces alpha-fetoprotein (AFP). Treatment includes: surgical resection, radiation, and chemotherapy. This tumor is very responsive to chemotherapy regimens that include cisplatinum."
      },
      "child_count": 7,
      "reference_id": "MONDO:0005744"
    },
    {
      "id": 7838,
      "label": "mediastinal malignant germ cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5094,
        7455,
        20308
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000366",
          "GARD:0024365",
          "MEDGEN:277334",
          "NCIT:C6446",
          "SCTID:713293002",
          "UMLS:C1334597"
        ],
        "synonyms": [
          "malignant mediastinal germ cell tumor",
          "malignant mediastinal germ cell tumour",
          "mediastinal germ cell tumor, malignant",
          "mediastinal malignant germ cell tumor",
          "thymic malignant germ cell tumor",
          "thymic malignant germ cell tumour",
          "malignant germ cell neoplasm of mediastinum",
          "malignant germ cell neoplasm of the mediastinum",
          "malignant germ cell tumor of mediastinum",
          "malignant germ cell tumor of the mediastinum",
          "malignant germ cell tumour of mediastinum",
          "malignant germ cell tumour of the mediastinum",
          "malignant mediastinal germ cell neoplasm"
        ],
        "definition": "An extragonadal malignant germ cell tumor that arises from the mediastinum. This category includes seminoma, embryonal carcinoma, yolk sac tumor, choriocarcinoma, mixed germ cell tumors, and immature malignant teratoma."
      },
      "child_count": 9,
      "reference_id": "MONDO:0006298"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 7365,
      "label": "yolk sac tumor"
    },
    {
      "id": 7838,
      "label": "mediastinal malignant germ cell tumor"
    }
  ]
}