{
  "id": 21295,
  "label": "eccrine carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0024240",
  "properties": {
    "xrefs": [
      "DOID:4920",
      "ICDO:8413/3",
      "MEDGEN:690083",
      "NCIT:C27255",
      "SCTID:400173004",
      "UMLS:C1266066"
    ],
    "synonyms": [
      "carcinoma of eccrine sweat gland",
      "carcinoma, eccrine gland, malignant",
      "eccrine adenocarcinoma",
      "eccrine adenocarcinoma (morphologic abnormality)",
      "eccrine carcinoma",
      "eccrine carcinoma of skin",
      "eccrine sweat gland adenocarcinoma",
      "eccrine sweat gland carcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0002051",
        "name": "integumentary system disorder"
      }
    ],
    "definition": "An adenocarcinoma with eccrine differentiation arising from the sweat glands. It includes the following subtypes: ductal eccrine adenocarcinoma, papillary eccrine carcinoma, and eccrine porocarcinoma."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 6,
  "parents": [
    {
      "id": 7162,
      "label": "eccrine sweat gland cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4230,
        4329
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4921",
          "MEDGEN:233660",
          "NCIT:C5559",
          "UMLS:C1334577"
        ],
        "synonyms": [
          "cancer of eccrine sweat gland",
          "eccrine sweat gland cancer",
          "malignant eccrine neoplasm",
          "malignant eccrine neoplasm of skin",
          "malignant eccrine neoplasm of the skin",
          "malignant eccrine skin neoplasm",
          "malignant eccrine skin tumor",
          "malignant eccrine skin tumour",
          "malignant eccrine sweat gland neoplasm",
          "malignant eccrine tumor",
          "malignant eccrine tumor of skin",
          "malignant eccrine tumor of the skin",
          "malignant eccrine tumour",
          "malignant eccrine tumour of skin",
          "malignant eccrine tumour of the skin",
          "malignant neoplasm of eccrine sweat gland"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "An cancer with eccrine differentiation arising from the sweat glands.B"
      },
      "child_count": 2,
      "reference_id": "MONDO:0005506"
    },
    {
      "id": 7178,
      "label": "sweat gland carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4329,
        6712,
        8398
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5667",
          "EFO:0005591",
          "ICDO:8400/3",
          "MEDGEN:234685",
          "NCIT:C6938",
          "ONCOTREE:AECA",
          "UMLS:C1412016"
        ],
        "synonyms": [
          "carcinoma of sweat gland",
          "carcinoma of the sweat gland",
          "carcinoma, sweat gland, malignant",
          "sweat gland carcinoma",
          "sweat gland carcinoma/apocrine eccrine carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A carcinoma arising from the sweat glands. Representative examples include tubular carcinoma, spiradenocarcinoma, eccrine carcinoma, hidradenocarcinoma, and apocrine carcinoma."
      },
      "child_count": 12,
      "reference_id": "MONDO:0005524"
    }
  ],
  "children": [
    {
      "id": 5439,
      "label": "papillary eccrine carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4583,
        21295
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5591",
          "NCIT:C27254",
          "SCTID:254709009"
        ],
        "synonyms": [
          "papillary apocrine fibroadenoma",
          "papillary eccrine adenoma",
          "papillary eccrine carcinoma",
          "tubular apocrine adenoma",
          "digital papillary adenocarcinoma",
          "eccrine papillary adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ]
      },
      "child_count": 2,
      "reference_id": "MONDO:0003531"
    },
    {
      "id": 5726,
      "label": "vulvar eccrine adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        21295,
        21365
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6339",
          "GARD:0023701",
          "MEDGEN:384495",
          "NCIT:C40305",
          "UMLS:C2202743"
        ],
        "synonyms": [
          "eccrine carcinoma of mammalian vulva",
          "mammalian vulva eccrine carcinoma",
          "vulvar eccrine adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "An eccrine adenocarcinoma that arises from the sweat glands in the vulva."
      },
      "child_count": 2,
      "reference_id": "MONDO:0003861"
    },
    {
      "id": 6221,
      "label": "malignant spiradenoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        21295,
        21606
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7960",
          "GARD:0010466",
          "ICDO:8403/3",
          "MEDGEN:266097",
          "NCIT:C5117",
          "SCTID:403942003",
          "UMLS:C1266063"
        ],
        "synonyms": [
          "Spiradenocarcinoma",
          "malignant eccrine spiradenoma",
          "malignant eccrine spiradenoma (morphologic abnormality)",
          "malignant spiradenoma",
          "spiradenoma, malignant"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A very rare, aggressive carcinoma of the sweat glands arising from malignant transformation of a long standing spiradenoma. It usually grows in the upper extremities, lower extremities, trunk, and head and neck. It has the tendency to recur and metastasize most often to the lymph nodes, bones, and lungs."
      },
      "child_count": 2,
      "reference_id": "MONDO:0004412"
    },
    {
      "id": 7745,
      "label": "eccrine porocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        21295
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7566",
          "EFO:1000229",
          "GARD:0007431",
          "ICDO:8409/3",
          "MEDGEN:266098",
          "MESH:D057090",
          "NCIT:C5560",
          "ONCOTREE:POCA",
          "SCTID:254708001",
          "UMLS:C1266065"
        ],
        "synonyms": [
          "eccrine porocarcinoma",
          "epidermotropic eccrine carcinoma",
          "malignant eccrine poroma",
          "porocarcinoma",
          "eccrine porocarcinoma of skin",
          "porocarcinoma/spiroadenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A carcinoma with eccrine differentiation arising from the sweat glands. It may arise de novo or as a malignant transformation of a pre-existing poroma. It usually grows in the legs, buttocks, feet, and trunk and usually presents as an ulcerative plaque. It is characterized by the presence of intraepidermal and dermal nests of malignant epithelial cells. It may recur after excision and metastasize to the lymph nodes and less frequently to distal anatomic sites."
      },
      "child_count": 1,
      "reference_id": "MONDO:0006189"
    },
    {
      "id": 21107,
      "label": "eccrine mucinous carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        21295
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:577240",
          "UMLS:C0346020"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0023039"
    },
    {
      "id": 21296,
      "label": "ductal eccrine adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        21295
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5570",
          "MEDGEN:266048",
          "NCIT:C43345",
          "SCTID:403939009",
          "UMLS:C1260964"
        ],
        "synonyms": [
          "ductal eccrine adenocarcinoma",
          "ductal eccrine carcinoma",
          "malignant acrospiroma",
          "sweat gland carcinoma of the hand",
          "eccrine ductal carcinoma (morphologic abnormality)",
          "eccrine ductal carcinoma of skin",
          "hidradenocarcinoma",
          "malignant hidradenoma",
          "primary mucoepidermoid cutaneous carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0024245"
    }
  ],
  "roots": [
    {
      "id": 7162,
      "label": "eccrine sweat gland cancer"
    },
    {
      "id": 7178,
      "label": "sweat gland carcinoma"
    }
  ]
}