{
  "id": 21360,
  "label": "colorectal carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0024331",
  "properties": {
    "xrefs": [
      "DOID:0080199",
      "EFO:1001951",
      "MEDGEN:3170",
      "NCIT:C2955",
      "UMLS:C0009402"
    ],
    "synonyms": [
      "cancer of large bowel",
      "cancer of large intestine",
      "cancer of the large bowel",
      "cancer of the large intestine",
      "colorectal (colon or rectal) cancer",
      "colorectal cancer",
      "large bowel cancer",
      "large intestine cancer",
      "CRC",
      "carcinoma of colorectum",
      "carcinoma of large bowel",
      "carcinoma of large intestine",
      "carcinoma of the large bowel",
      "carcinoma of the large intestine",
      "colorectal carcinoma",
      "colorectum carcinoma",
      "large bowel carcinoma",
      "large intestine carcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      }
    ],
    "definition": "A malignant epithelial neoplasm that arises from the colon or rectum and invades through the muscularis mucosa into the submucosa. The vast majority are adenocarcinomas."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 7221,
      "label": "colorectal cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7022,
        7430
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5672",
          "DOID:9256",
          "MEDGEN:83428",
          "NCIT:C4978",
          "OMIM:114500",
          "Orphanet:466667",
          "SCTID:363510005",
          "UMLS:C0346629"
        ],
        "synonyms": [
          "cancer of colorectum",
          "cancer of large bowel",
          "cancer of large intestine",
          "cancer of the large bowel",
          "colon cancer, advanced, somatic",
          "colon cancer, somatic",
          "colorectal cancer",
          "colorectal cancer with chromosomal instability, somatic",
          "colorectal cancer, autosomal dominant, somatic mutation",
          "colorectal cancer, somatic",
          "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation",
          "colorectum cancer",
          "malignant colorectal neoplasm",
          "malignant colorectal tumor",
          "malignant colorectal tumour",
          "malignant colorectum neoplasm",
          "malignant large bowel neoplasm",
          "malignant large bowel tumor",
          "malignant large bowel tumour",
          "malignant large intestine neoplasm",
          "malignant large intestine tumor",
          "malignant large intestine tumour",
          "malignant neoplasm of colorectum",
          "malignant neoplasm of large bowel",
          "malignant neoplasm of large intestine",
          "malignant neoplasm of the large bowel",
          "malignant neoplasm of the large intestine",
          "malignant tumor of large bowel",
          "malignant tumor of large intestine",
          "malignant tumor of the large bowel",
          "malignant tumor of the large intestine",
          "malignant tumour of large bowel",
          "malignant tumour of large intestine",
          "malignant tumour of the large bowel",
          "malignant tumour of the large intestine",
          "CRC",
          "colon cancer",
          "colon cancer, susceptibility to, autosomal dominant, somatic mutation",
          "large intestine cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma."
      },
      "child_count": 10,
      "reference_id": "MONDO:0005575"
    },
    {
      "id": 7738,
      "label": "digestive system carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4587,
        6734
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050922",
          "EFO:1000218",
          "HP:0002672",
          "MEDGEN:57467",
          "NCIT:C96963",
          "UMLS:C0151544"
        ],
        "synonyms": [
          "carcinoma of digestive system",
          "carcinoma of the gastrointestinal system",
          "digestive system carcinoma",
          "gastrointestinal carcinoma",
          "gastrointestinal carcinoma (disease)",
          "gastrointestinal system carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A malignant neoplasm that arises from the epithelium of any part of the digestive system. Representative examples include colorectal carcinoma, esophageal carcinoma, and pancreatic carcinoma."
      },
      "child_count": 32,
      "reference_id": "MONDO:0006181"
    }
  ],
  "children": [
    {
      "id": 4179,
      "label": "colon carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20304,
        21360,
        21434
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1520",
          "EFO:1001950",
          "MEDGEN:147065",
          "NCIT:C4910",
          "SCTID:269533000",
          "UMLS:C0699790",
          "icd11.foundation:865099988"
        ],
        "synonyms": [
          "colon cancer",
          "carcinoma of colon",
          "carcinoma of the colon",
          "colon carcinoma",
          "colonic carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A carcinoma that arises from epithelial cells of the colon"
      },
      "child_count": 18,
      "reference_id": "MONDO:0002032"
    },
    {
      "id": 6746,
      "label": "colorectal adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6712,
        21360
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050861",
          "DOID:0050913",
          "EFO:0000365",
          "MEDGEN:230816",
          "NCIT:C5105",
          "ONCOTREE:COADREAD",
          "SCTID:408645001",
          "UMLS:C1319315"
        ],
        "synonyms": [
          "adenocarcinoma of large bowel",
          "adenocarcinoma of large intestine",
          "adenocarcinoma of the large bowel",
          "adenocarcinoma of the large intestine",
          "colorectal (colon or rectal) adenocarcinoma",
          "colorectal adenocarcinoma",
          "colorectum adenocarcinoma",
          "large bowel adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "The most common type of colorectal carcinoma. It is characterized by the presence of malignant glandular epithelial cells invading through the muscularis mucosa into the submucosa. Histologic variants include mucinous adenocarcinoma, signet ring cell carcinoma, medullary carcinoma, serrated adenocarcinoma, cribriform comedo-type adenocarcinoma, and micropapillary adenocarcinoma."
      },
      "child_count": 10,
      "reference_id": "MONDO:0005008"
    },
    {
      "id": 7726,
      "label": "colorectal squamous cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6823,
        21360
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000198",
          "MEDGEN:317527",
          "NCIT:C43588",
          "UMLS:C1707442"
        ],
        "synonyms": [
          "colorectal (colon or rectal) squamous cell cancer",
          "colorectal squamous cell cancer",
          "colorectal squamous cell carcinoma",
          "colorectum squamous cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A very rare colorectal carcinoma characterized by the presence of a malignant squamous cell infiltrate."
      },
      "child_count": 6,
      "reference_id": "MONDO:0006165"
    },
    {
      "id": 23485,
      "label": "rectal carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        8006,
        21360,
        21431
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:40100",
          "NCIT:C9382",
          "UMLS:C0007113"
        ],
        "synonyms": [
          "cancer of rectum",
          "cancer of the rectum",
          "rectal cancer",
          "carcinoma of rectum",
          "carcinoma of the rectum",
          "rectal carcinoma",
          "rectum carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A malignant epithelial neoplasm that arises from the rectum and invades through the muscularis mucosa into the submucosa. The vast majority are adenocarcinomas."
      },
      "child_count": 18,
      "reference_id": "MONDO:0044937"
    }
  ],
  "roots": [
    {
      "id": 7221,
      "label": "colorectal cancer"
    },
    {
      "id": 7738,
      "label": "digestive system carcinoma"
    }
  ]
}