{
  "id": 21365,
  "label": "vulvar adenocarcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0024336",
  "properties": {
    "xrefs": [
      "DOID:2098",
      "GARD:0022007",
      "MEDGEN:234480",
      "NCIT:C6380",
      "Orphanet:494454",
      "UMLS:C1336975"
    ],
    "synonyms": [
      "adenocarcinoma of the vulva",
      "adenocarcinoma of vulva",
      "mammalian vulva adenocarcinoma",
      "vulva adenocarcinoma",
      "vulvar adenocarcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      }
    ],
    "definition": "An adenocarcinoma that arises from the vulva. Representative examples include Bartholin gland adenocarcinoma, eccrine adenocarcinoma, apocrine adenocarcinoma, and sebaceous carcinoma."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 7,
  "parents": [
    {
      "id": 4321,
      "label": "vulvar glandular neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20293,
        21312
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2076",
          "MEDGEN:276991",
          "NCIT:C40292",
          "UMLS:C1520082"
        ],
        "synonyms": [
          "mammalian vulva glandular cell neoplasm",
          "vulvar glandular neoplasm",
          "vulvar glandular tumor",
          "vulvar glandular tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A benign or malignant neoplasm that arises from the vulva and is composed of glandular epithelial cells. Representative examples include adenoma of the minor vestibular glands, Bartholin gland adenoma, and Bartholin gland adenocarcinoma."
      },
      "child_count": 8,
      "reference_id": "MONDO:0002198"
    },
    {
      "id": 6712,
      "label": "adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6734,
        21312
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "CSP:2000-0386",
          "DOID:299",
          "EFO:0000228",
          "ICDO:8140/3",
          "MEDGEN:122",
          "MESH:D000230",
          "NCIT:C2852",
          "ONCOTREE:ADNOS",
          "SCTID:443961001",
          "UMLS:C0001418"
        ],
        "synonyms": [
          "adenocarcinoma",
          "adenocarcinoma NOS (morphologic abnormality)",
          "adenocarcinoma, malignant",
          "adenocarcinoma, no subtype (morphologic abnormality)",
          "adenocarcinomas",
          "ADNOS"
        ],
        "definition": "A common cancer characterized by the presence of malignant glandular cells. Morphologically, adenocarcinomas are classified according to the growth pattern (e.g., papillary, alveolar) or according to the secreting product (e.g., mucinous, serous). Representative examples of adenocarcinoma are ductal and lobular breast carcinoma, lung adenocarcinoma, renal cell carcinoma, hepatocellular carcinoma (hepatoma), colon adenocarcinoma, and prostate adenocarcinoma."
      },
      "child_count": 128,
      "reference_id": "MONDO:0004970"
    },
    {
      "id": 6931,
      "label": "vulvar carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3735,
        6734
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1294",
          "EFO:0002921",
          "GARD:0009349",
          "MEDGEN:146159",
          "NCIT:C4866",
          "Orphanet:494418",
          "SCTID:447882007",
          "UMLS:C0677055"
        ],
        "synonyms": [
          "cancer of the vulva",
          "cancer of vulva",
          "vulva cancer",
          "vulvar cancer",
          "carcinoma of mammalian vulva",
          "carcinoma of the vulva",
          "carcinoma of vulva",
          "mammalian vulva carcinoma",
          "vulva carcinoma",
          "vulvar carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A carcinoma that arises from epithelial cells of the mammalian vulva"
      },
      "child_count": 18,
      "reference_id": "MONDO:0005215"
    }
  ],
  "children": [
    {
      "id": 4330,
      "label": "vulval Paget disease",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        9488,
        21365
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2097",
          "GARD:0023083",
          "ICD9:233.39",
          "MEDGEN:266154",
          "NCIT:C4027",
          "SCTID:254898001",
          "UMLS:C1275217"
        ],
        "synonyms": [
          "Paget disease of the vulva",
          "Paget's disease of the vulva",
          "Paget's disease of vulva",
          "mammalian vulva Paget disease",
          "vulva Paget's disease",
          "vulval Paget's disease",
          "vulvar Paget's disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "An uncommon intraepithelial malignant neoplasm of eccrine or apocrine origin, arising from the vulva. It usually affects post-menopausal women. In approximately 10-20% of the cases there is an associated anorectal, or urothelial carcinoma or a skin appendage adenocarcinoma identified. It presents as a red, eczematous lesion. Microscopically, it is characterized by the presence of the typical Paget cells which are large, round cells with abundant cytoplasm and prominent nuclei."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002207"
    },
    {
      "id": 5525,
      "label": "vulvar sebaceous carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        8388,
        21365
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5761",
          "GARD:0023594",
          "MEDGEN:276996",
          "NCIT:C40309",
          "UMLS:C1520094"
        ],
        "synonyms": [
          "mammalian vulva sebaceous adenocarcinoma",
          "sebaceous adenocarcinoma of mammalian vulva"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A carcinoma that arises from the vulva. It is characterized by the presence of malignant basaloid glandular epithelial cells that resemble sebaceous epithelium and are arranged in cords and nests."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003636"
    },
    {
      "id": 5720,
      "label": "Bartholin gland adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4848,
        21365
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6316",
          "GARD:0023696",
          "MEDGEN:116035",
          "NCIT:C7719",
          "UMLS:C0238016"
        ],
        "synonyms": [
          "Bartholin gland adenocarcinoma",
          "adenocarcinoma of the Bartholin's gland",
          "major vestibular gland adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A carcinoma that arises from glandular epithelial cells of the major vestibular gland."
      },
      "child_count": 2,
      "reference_id": "MONDO:0003853"
    },
    {
      "id": 5726,
      "label": "vulvar eccrine adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        21295,
        21365
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6339",
          "GARD:0023701",
          "MEDGEN:384495",
          "NCIT:C40305",
          "UMLS:C2202743"
        ],
        "synonyms": [
          "eccrine carcinoma of mammalian vulva",
          "mammalian vulva eccrine carcinoma",
          "vulvar eccrine adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "An eccrine adenocarcinoma that arises from the sweat glands in the vulva."
      },
      "child_count": 2,
      "reference_id": "MONDO:0003861"
    },
    {
      "id": 5744,
      "label": "vulvar apocrine adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5169,
        21365
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6448",
          "GARD:0023712",
          "MEDGEN:384494",
          "NCIT:C40308",
          "UMLS:C2202741"
        ],
        "synonyms": [
          "apocrine adenocarcinoma of mammalian vulva",
          "mammalian vulva apocrine adenocarcinoma",
          "vulvar apocrine adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "An apocrine adenocarcinoma that arises from the sweat glands in the vulva."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003881"
    },
    {
      "id": 5996,
      "label": "adenocarcinoma of skene gland origin",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4045,
        21365
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7284",
          "GARD:0023862",
          "MEDGEN:282906",
          "NCIT:C39863",
          "UMLS:C1527427"
        ],
        "synonyms": [
          "adenocarcinoma of Skene gland",
          "adenocarcinoma of Skene gland origin",
          "carcinoma of Skene gland",
          "carcinoma of Skene's gland",
          "carcinoma of paraurethral gland",
          "paraurethral gland adenocarcinoma",
          "paraurethral gland carcinoma",
          "Skene gland carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A rare adenocarcinoma arising from Skene gland. It presents as a periurethral or anterior vaginal submucosal mass. It is characterized by morphological features similar to prostate adenocarcinoma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004173"
    },
    {
      "id": 6101,
      "label": "vulvar clear cell hidradenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7795,
        21365
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7567",
          "GARD:0023911",
          "MEDGEN:275614",
          "NCIT:C40307",
          "UMLS:C1520076"
        ],
        "synonyms": [
          "vulvar clear cell hidradenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A vulvar sweat gland carcinoma characterized by the presence of clear cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004283"
    }
  ],
  "roots": [
    {
      "id": 4321,
      "label": "vulvar glandular neoplasm"
    },
    {
      "id": 6712,
      "label": "adenocarcinoma"
    },
    {
      "id": 6931,
      "label": "vulvar carcinoma"
    }
  ]
}