{
  "id": 21381,
  "label": "complex sleep apnea",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0024358",
  "properties": {
    "xrefs": [
      "DOID:0080302",
      "MEDGEN:83271",
      "SCTID:230493001",
      "UMLS:C0338495"
    ],
    "synonyms": [
      "CompSAS",
      "complex sleep apnea"
    ],
    "categories": [
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      },
      {
        "ref": "MONDO:0005087",
        "name": "respiratory system disorder"
      }
    ],
    "definition": "A distinct form of sleep-disordered breathing characterized as central sleep apnea (CSA), and presents in obstructive sleep apnea (OSA) patients during initial treatment with a continuous positive airway pressure (CPAP) device."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 6507,
      "label": "central sleep apnea syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4370,
        6990
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9220",
          "MEDGEN:854402",
          "MESH:D020182",
          "NCIT:C27169",
          "SCTID:27405005",
          "UMLS:C3887547"
        ],
        "synonyms": [
          "central sleep apnea syndrome",
          "central sleep apnea, primary",
          "primary central sleep apnea",
          "secondary central sleep apnea",
          "Apneas, central",
          "Apneas, central sleep",
          "Breathings, central sleep-disordered",
          "alveolar hypoventilation, central",
          "alveolar hypoventilations, central",
          "apnea, central",
          "apnea, central sleep",
          "apnea, sleep, central",
          "breathing, central sleep-disordered",
          "central Apneas",
          "central alveolar hypoventilation",
          "central alveolar hypoventilation syndrome",
          "central apnea",
          "central sleep Apneas",
          "central sleep apnea",
          "central sleep apnea, secondary",
          "central sleep disordered breathing",
          "central sleep-disordered Breathings",
          "central sleep-disordered breathing",
          "hypoventilation, central alveolar",
          "hypoventilations, central alveolar",
          "ondine syndrome",
          "sleep Apneas, central",
          "sleep apnea, lethal central",
          "sleep disordered breathing, central",
          "sleep-disordered Breathings, central",
          "sleep-disordered breathing, central"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A broad classification of disorders which includes 6 subtypes (primary central sleep apnea, central sleep apnea due to Cheyne-Stokes breathing pattern, central sleep apnea due to medical condition not Cheyne-Stokes, central sleep apnea due to high-altitude periodic breathing, central sleep apnea due to drug or substance and primary sleep apnea of infancy) that are each characterized by interruptions in breathing while asleep. It is caused by improper signaling from the brainstem to respiratory muscles and is triggered by either hypoventilation or hyperventilation. In adults, this disorder may arise following a stroke, congestive heart failure, trauma, infection or the use of narcotic medications. It is more common in older males and may present as a co-morbid condition to obesity. Clinical signs include snoring, insomnia or hypersomnia, difficulty concentrating and fatigue. Recurrent episodes of hypoxia/hypoxemia have long-term detrimental effects on cardiovascular health."
      },
      "child_count": 10,
      "reference_id": "MONDO:0004731"
    },
    {
      "id": 8555,
      "label": "obstructive sleep apnea syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4370,
        6990
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050848",
          "EFO:0003918",
          "HP:0002870",
          "ICD10CM:G47.33",
          "ICD9:327.23",
          "MEDGEN:101045",
          "MESH:D020181",
          "NCIT:C27168",
          "OMIM:107650",
          "SCTID:78275009",
          "UMLS:C0520679"
        ],
        "synonyms": [
          "obstructive sleep apnea",
          "obstructive sleep apnea syndrome",
          "Apneas, obstructive sleep",
          "OSAHS",
          "Osa",
          "apnea, obstructive sleep",
          "obstructive sleep Apneas",
          "sleep Apneas, obstructive",
          "sleep apnea hypopnea syndrome",
          "sleep apnea syndrome, obstructive",
          "sleep apnea/hypopnea syndrome",
          "syndrome, obstructive sleep apnea",
          "syndrome, sleep apnea, obstructive",
          "syndrome, upper airway resistance, sleep apnea",
          "upper airway resistance sleep apnea syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "Cessation of air flow during sleep due to upper airway obstruction."
      },
      "child_count": 2,
      "reference_id": "MONDO:0007147"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 6507,
      "label": "central sleep apnea syndrome"
    },
    {
      "id": 8555,
      "label": "obstructive sleep apnea syndrome"
    }
  ]
}