{
  "id": 21382,
  "label": "central sleep apnea due to periodic breathing",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0024359",
  "properties": {
    "xrefs": [
      "ICD9:327.27",
      "ICD9:786.09",
      "MEDGEN:783212",
      "SCTID:85721000119105",
      "UMLS:C3662057"
    ],
    "synonyms": [
      "central sleep apnea due to periodic breathing",
      "Cheyne–Stokes breathing",
      "central sleep apnea with Cheyne–Stokes breathing"
    ],
    "categories": [
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      },
      {
        "ref": "MONDO:0005087",
        "name": "respiratory system disorder"
      }
    ],
    "definition": "A sleep-related disorder characterized by cyclical breathing patterns where periods of shallow or absent breathing (apneas or hypopneas) alternate with periods of deeper breathing (hyperpnea). This cyclical pattern is caused by an instability in the body's respiratory control system, where the brain doesn't properly regulate breathing effort."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 6507,
      "label": "central sleep apnea syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4370,
        6990
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9220",
          "MEDGEN:854402",
          "MESH:D020182",
          "NCIT:C27169",
          "SCTID:27405005",
          "UMLS:C3887547"
        ],
        "synonyms": [
          "central sleep apnea syndrome",
          "central sleep apnea, primary",
          "primary central sleep apnea",
          "secondary central sleep apnea",
          "Apneas, central",
          "Apneas, central sleep",
          "Breathings, central sleep-disordered",
          "alveolar hypoventilation, central",
          "alveolar hypoventilations, central",
          "apnea, central",
          "apnea, central sleep",
          "apnea, sleep, central",
          "breathing, central sleep-disordered",
          "central Apneas",
          "central alveolar hypoventilation",
          "central alveolar hypoventilation syndrome",
          "central apnea",
          "central sleep Apneas",
          "central sleep apnea",
          "central sleep apnea, secondary",
          "central sleep disordered breathing",
          "central sleep-disordered Breathings",
          "central sleep-disordered breathing",
          "hypoventilation, central alveolar",
          "hypoventilations, central alveolar",
          "ondine syndrome",
          "sleep Apneas, central",
          "sleep apnea, lethal central",
          "sleep disordered breathing, central",
          "sleep-disordered Breathings, central",
          "sleep-disordered breathing, central"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A broad classification of disorders which includes 6 subtypes (primary central sleep apnea, central sleep apnea due to Cheyne-Stokes breathing pattern, central sleep apnea due to medical condition not Cheyne-Stokes, central sleep apnea due to high-altitude periodic breathing, central sleep apnea due to drug or substance and primary sleep apnea of infancy) that are each characterized by interruptions in breathing while asleep. It is caused by improper signaling from the brainstem to respiratory muscles and is triggered by either hypoventilation or hyperventilation. In adults, this disorder may arise following a stroke, congestive heart failure, trauma, infection or the use of narcotic medications. It is more common in older males and may present as a co-morbid condition to obesity. Clinical signs include snoring, insomnia or hypersomnia, difficulty concentrating and fatigue. Recurrent episodes of hypoxia/hypoxemia have long-term detrimental effects on cardiovascular health."
      },
      "child_count": 10,
      "reference_id": "MONDO:0004731"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 6507,
      "label": "central sleep apnea syndrome"
    }
  ]
}