{ "id": 21432, "label": "liver and intrahepatic bile duct neoplasm", "model": { "label": "Mondo Disease Ontology (MONDO)", "source": 0 }, "type_id": 0, "reference_id": "MONDO:0024477", "properties": { "xrefs": [ "DOID:916", "MEDGEN:232599", "NCIT:C7103", "NCIT:C7106", "ONCOTREE:LIVER", "SCTID:126851005", "UMLS:C1333976" ], "synonyms": [ "epithelial hepatic and intrahepatic bile duct neoplasm", "hepatic and intrahepatic bile duct neoplasm", "liver and intrahepatic bile duct epithelial neoplasm", "liver and intrahepatic bile duct neoplasm", "liver neoplasm", "liver neoplasm (disease)", "liver tumor", "liver tumour", "neoplasm of liver", "tumor of liver", "tumour of liver" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0005151", "name": "endocrine system disorder" } ], "definition": "A benign or malignant neoplasm that affects the liver parenchyma or intrahepatic bile ducts. Representative examples of benign neoplasms include hepatocellular adenoma, and bile duct adenoma. Representative examples of malignant neoplasms include hepatocellular carcinoma, intrahepatic cholangiocarcinoma, and lymphoma." }, "isLeaf": false, "isRoot": false, "child_count": 17, "parents": [ { "id": 4223, "label": "endocrine gland neoplasm", "isLeaf": false, "isRoot": false, "parents": [ 6798, 6875 ], "type_id": 0, "properties": { "xrefs": [ "EFO:0003769", "ICD9:239.7", "MEDGEN:4044", "NCIT:C3010", "SCTID:387922007", "UMLS:C0014132" ], "synonyms": [ "endocrine gland neoplasm (disease)", "endocrine gland tumor", "endocrine gland tumour", "endocrine neoplasm", "endocrine system neoplasm", "endocrine system tumor", "endocrine system tumour", "endocrine tumor", "endocrine tumour", "neoplasm of endocrine gland", "tumor of endocrine gland", "tumour of endocrine gland", "malignant endocrine tumor", "malignant endocrine tumour" ], "categories": [ { "ref": "MONDO:0005151", "name": "endocrine system disorder" } ], "definition": "A benign or malignant neoplasm arising from the epithelial cells of an endocrine organ. Representative examples include pituitary gland adenoma, pituitary gland carcinoma, thyroid gland carcinoma, carcinoid tumor, and neuroendocrine carcinoma." }, "child_count": 28, "reference_id": "MONDO:0002082" }, { "id": 4585, "label": "hepatobiliary neoplasm", "isLeaf": false, "isRoot": false, "parents": [ 4586, 20434 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0080355", "EFO:0008550", "MEDGEN:208891", "NCIT:C8614", "UMLS:C0854196" ], "synonyms": [ "hepatic and biliary neoplasms", "hepatic and biliary tumors", "hepatic and biliary tumours", "hepatic, biliary, and gallbladder neoplasms", "hepato-biliary neoplasm", "hepato-biliary tumor", "hepato-biliary tumour", "hepatobiliary neoplasm", "hepatobiliary system neoplasm", "hepatobiliary system neoplasm (disease)", "hepatobiliary system tumor", "hepatobiliary system tumour", "hepatobiliary tumor", "hepatobiliary tumors", "hepatobiliary tumour", "hepatobiliary tumours", "liver and biliary neoplasm", "liver and biliary system neoplasm", "neoplasm of hepatobiliary system", "tumor of hepatobiliary system", "tumour of hepatobiliary system", "hepatobiliary benign neoplasm" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" } ], "definition": "A benign or malignant neoplasm that affects the liver parenchyma, bile ducts, and gallbladder. Representative examples of benign neoplasms include hepatocellular adenoma, bile duct adenoma, and gallbladder lipoma. Representative examples of malignant neoplasms include hepatocellular carcinoma, intrahepatic and extrahepatic cholangiocarcinoma, and gallbladder carcinoma." }, "child_count": 4, "reference_id": "MONDO:0002514" }, { "id": 6878, "label": "liver disorder", "isLeaf": false, "isRoot": false, "parents": [ 4586, 6875 ], "type_id": 0, "properties": { "xrefs": [ "DOID:409", "EFO:0001421", "ICD10CM:K70-K77", "ICD9:573.8", "ICD9:573.9", "MEDGEN:893061", "MESH:D008107", "NCIT:C3196", "SCTID:235856003", "UMLS:C4021780", "icd11.foundation:1784240230" ], "synonyms": [ "disease of liver", "disease or disorder of liver", "disorder of liver", "hepatic disease", "hepatic disorder", "liver and intrahepatic bile duct disorder", "liver disease", "liver disease or disorder", "liver disorder" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0005151", "name": "endocrine system disorder" } ], "definition": "A disease involving the liver." }, "child_count": 64, "reference_id": "MONDO:0005154" } ], "children": [ { "id": 3234, "label": "liver lipoma", "isLeaf": false, "isRoot": false, "parents": [ 3032, 6833, 21432, 25554 ], "type_id": 0, "properties": { "xrefs": [ "DOID:10190", "MEDGEN:232277", "NCIT:C5750", "UMLS:C1333970" ], "synonyms": [ "hepatic lipoma", "lipoma of liver", "lipoma of the liver", "liver lipoma" ], "categories": [ { "ref": "MONDO:0002081", "name": "musculoskeletal system disorder" }, { "ref": "MONDO:0003900", "name": "connective tissue disorder" }, { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0005151", "name": "endocrine system disorder" } ], "definition": "A rare benign adipose tissue neoplasm of the liver." }, "child_count": 4, "reference_id": "MONDO:0000965" }, { "id": 4494, "label": "liver hemangioma", "isLeaf": false, "isRoot": false, "parents": [ 3032, 4441, 21432, 25554 ], "type_id": 0, "properties": { "xrefs": [ "DOID:271", "MEDGEN:66765", "NCIT:C3869", "SCTID:93469006", "UMLS:C0238246" ], "synonyms": [ "angioma of liver", "hemangioma of liver", "hepatic angioma", "liver hemangioma", "angioma of the liver", "hemangioma of the liver", "hepatic hemangioma", "liver angioma" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0004995", "name": "cardiovascular disorder" }, { "ref": "MONDO:0005151", "name": "endocrine system disorder" } ], "definition": "A hemangioma arising from the liver." }, "child_count": 4, "reference_id": "MONDO:0002404" }, { "id": 4660, "label": "hepatic angiomyolipoma", "isLeaf": true, "isRoot": false, "parents": [ 4658, 21432 ], "type_id": 0, "properties": { "xrefs": [ "DOID:3317", "GARD:0023185", "MEDGEN:272705", "NCIT:C27485", "UMLS:C1333962" ], "synonyms": [ "liver PEComa", "liver angiomyolipoma" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0005151", "name": "endocrine system disorder" } ], "definition": "An angiomyolipoma arising from the liver." }, "child_count": 0, "reference_id": "MONDO:0002605" }, { "id": 4735, "label": "liver cancer", "isLeaf": false, "isRoot": false, "parents": [ 4587, 20310, 21432 ], "type_id": 0, "properties": { "xrefs": [ "DOID:3571", "GARD:0027613", "ICD9:155.0", "ICD9:155.2", "MEDGEN:87520", "NCIT:C34803", "SCTID:93870000", "UMLS:C0345904", "icd11.foundation:1605020868" ], "synonyms": [ "cancer of liver", "hepatic cancer", "liver cancer", "malignant liver neoplasm", "malignant neoplasm of liver", "malignant neoplasm of liver, not specified as primary or secondary", "malignant neoplasm of liver, primary", "malignant tumour of liver", "primary liver cancer", "primary malignant liver neoplasm", "primary malignant neoplasm of liver", "primary cancer of liver", "primary tumor of the liver", "primary tumour of the liver" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0005151", "name": "endocrine system disorder" } ], "definition": "An epithelial or non-epithelial malignant neoplasm that arises from the liver. Representative examples include hepatocellular carcinoma, intrahepatic cholangiocarcinoma, lymphoma, and sarcoma." }, "child_count": 15, "reference_id": "MONDO:0002691" }, { "id": 6484, "label": "liver solitary fibrous tumor", "isLeaf": true, "isRoot": false, "parents": [ 6889, 16812, 21432 ], "type_id": 0, "properties": { "xrefs": [ "DOID:907", "GARD:0024092", "MEDGEN:232273", "NCIT:C5752", "UMLS:C1333965" ], "synonyms": [ "fibroma of liver", "fibroma of the liver", "hepatic fibroma", "liver fibroma", "liver localised fibrous mesothelioma", "liver localised fibrous tumour", "liver localized fibrous mesothelioma", "liver localized fibrous tumor", "liver solitary fibrous tumor" ], "categories": [ { "ref": "MONDO:0003900", "name": "connective tissue disorder" }, { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0005151", "name": "endocrine system disorder" } ], "definition": "A solitary fibrous tumor that arises from the liver. It affects females more frequently than males. Signs and symptoms include the presence of an abdominal mass and abdominal discomfort." }, "child_count": 0, "reference_id": "MONDO:0004705" }, { "id": 6499, "label": "liver leiomyoma", "isLeaf": false, "isRoot": false, "parents": [ 3032, 3776, 21432, 25554 ], "type_id": 0, "properties": { "xrefs": [ "DOID:917", "MEDGEN:232276", "NCIT:C5753", "UMLS:C1333968" ], "synonyms": [ "hepatic leiomyoma", "leiomyoma of liver", "leiomyoma of the liver", "liver leiomyoma" ], "categories": [ { "ref": "MONDO:0002081", "name": "musculoskeletal system disorder" }, { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0005151", "name": "endocrine system disorder" } ], "definition": "A benign smooth muscle neoplasm arising from the liver. It is characterized by the presence of spindle cells with cigar-shaped nuclei, interlacing fascicles, and a whorled pattern." }, "child_count": 4, "reference_id": "MONDO:0004723" }, { "id": 6502, "label": "liver inflammatory myofibroblastic tumor", "isLeaf": true, "isRoot": false, "parents": [ 16551, 21432 ], "type_id": 0, "properties": { "xrefs": [ "DOID:918", "GARD:0024098", "MEDGEN:232275", "NCIT:C5858", "SCTID:717329009", "UMLS:C1333967" ], "synonyms": [ "liver inflammatory pseudotumor", "hepatic inflammatory myofibroblastic tumor", "hepatic inflammatory myofibroblastic tumour", "liver inflammatory myofibroblastic tumor", "inflammatory pseudotumor of liver", "inflammatory pseudotumor of the liver" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0005151", "name": "endocrine system disorder" } ], "definition": "A multinodular intermediate fibroblastic neoplasm arising from the liver. It is characterized by the presence of spindle-shaped fibroblasts and myofibroblasts, and a chronic inflammatory infiltrate composed of eosinophils, lymphocytes and plasma cells." }, "child_count": 0, "reference_id": "MONDO:0004726" }, { "id": 6998, "label": "biliary tract neoplasm", "isLeaf": false, "isRoot": false, "parents": [ 6624, 21432 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0050625", "EFO:0003891", "HP:0100574", "MEDGEN:14118", "ONCOTREE:BILIARY_TRACT", "SCTID:126853008", "UMLS:C0005426" ], "synonyms": [ "biliary tract neoplasm", "biliary tract neoplasm (disease)", "biliary tree neoplasm", "biliary tree neoplasm (disease)", "biliary tree tumor", "biliary tree tumour", "neoplasm of biliary tree", "tumor of biliary tree", "tumour of biliary tree", "BILIARY_TRACT", "tumour of the extrahepatic bile duct" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0005151", "name": "endocrine system disorder" } ], "definition": "A neoplasm that involves the biliary tract." }, "child_count": 4, "reference_id": "MONDO:0005304" }, { "id": 7792, "label": "hepatic granuloma", "isLeaf": true, "isRoot": false, "parents": [ 21432 ], "type_id": 0, "properties": { "xrefs": [ "EFO:1000291", "ICD9:572.8", "MEDGEN:155428", "SCTID:714253009", "UMLS:C0745754" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0005151", "name": "endocrine system disorder" } ], "definition": "A granuloma located in the liver." }, "child_count": 0, "reference_id": "MONDO:0006241" }, { "id": 16025, "label": "solitary necrotic nodule of the liver", "isLeaf": true, "isRoot": false, "parents": [ 21432 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0019743", "MEDGEN:755361", "Orphanet:100035", "SCTID:447058001", "UMLS:C2960192", "icd11.foundation:209168589" ], "synonyms": [ "hepatic solitary necrotic nodule" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0005151", "name": "endocrine system disorder" } ], "definition": "Solitary necrotic tumor of the liver is a rare nonmalignant hepatic lesion characterized by a mass with a completely necrotic core often partially calcified, surrounded by a dense hyalinized fibrous capsule containing elastin fibers. Patients are usually asymptomatic but some may suffer from intermittent abdominal pain or discomfort." }, "child_count": 0, "reference_id": "MONDO:0015049" }, { "id": 16548, "label": "undifferentiated embryonal sarcoma of the liver", "isLeaf": true, "isRoot": false, "parents": [ 21432 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0020145", "MEDGEN:902204", "ONCOTREE:UESL", "Orphanet:178315", "SCTID:716648006", "UMLS:C2205345" ], "synonyms": [ "UES", "embryonal sarcoma of the liver", "undifferentiated sarcoma of the liver" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0005151", "name": "endocrine system disorder" } ], "definition": "Embryonal sarcoma of the liver is a rare primary malignant hepatic neoplasm of childhood of mesenchymal origin. It can rarely occur in adults. It is characterized by abdominal mass, right upper quadrant or epigastric pain, nausea, anorexia, intermittent fever or headache." }, "child_count": 0, "reference_id": "MONDO:0015795" }, { "id": 18405, "label": "liver mesenchymal hamartoma", "isLeaf": true, "isRoot": false, "parents": [ 21432, 21433 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0002651", "MEDGEN:232278", "NCIT:C5751", "Orphanet:386", "SCTID:715397000", "UMLS:C1333971", "icd11.foundation:1416010483" ], "synonyms": [ "MHL", "VMC", "Von Meyenburg complexes disease", "biliary hamartoma", "hepatic mesenchymal hamartoma", "liver MH", "liver mesenchymal hamartoma", "mesenchymal hamartoma of liver", "mesenchymal hamartoma of the liver", "hepatic cystic hamartoma" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0005151", "name": "endocrine system disorder" } ], "definition": "A multicystic, tumor-like hamartomatous lesion that arises from the liver during fetal development. Clinically, it usually presents as an abdominal mass associated with abdominal distention. Following resection, the prognosis is usually good." }, "child_count": 0, "reference_id": "MONDO:0018308" }, { "id": 18830, "label": "hepatocellular adenoma", "isLeaf": false, "isRoot": false, "parents": [ 2884, 3032, 6714, 21432, 22952 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0050868", "EFO:0000762", "GARD:0018847", "ICDO:8170/0", "MEDGEN:61655", "MESH:D018248", "MedDRA:10019827", "NCIT:C3758", "ONCOTREE:LIAD", "Orphanet:54272", "UMLS:C0206669", "icd11.foundation:1481070735" ], "synonyms": [ "HCA", "adenoma of liver cells", "adenoma of the liver cells", "adenoma, hepatocellular, benign", "hepatocellular adenoma", "liver cell adenoma", "LIAD" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0005151", "name": "endocrine system disorder" } ], "definition": "A benign epithelial neoplasm arising from the hepatocytes. Grossly, it appears as a soft, round mass which often contains areas of hemorrhage and necrosis. Morphologically, the neoplastic cells resemble normal hepatocytes and form plates separated by sinusoids. Most patients have a history of contraceptive or anabolic steroids use." }, "child_count": 5, "reference_id": "MONDO:0018902" }, { "id": 19338, "label": "inflammatory pseudotumor of the liver", "isLeaf": true, "isRoot": false, "parents": [ 21432 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0019098", "Orphanet:90003" ], "synonyms": [ "IgG4-related hepatopathy" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0005151", "name": "endocrine system disorder" } ], "definition": "Inflammatory pseudotumor (IPT) of the liver is a rare benign tumor-like lesion." }, "child_count": 0, "reference_id": "MONDO:0019528" }, { "id": 22819, "label": "fibrohistiocytic inflammatory pseudotumor of the liver", "isLeaf": true, "isRoot": false, "parents": [ 21432 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0022239", "ICD10CM:K75.8", "MEDGEN:1843230", "Orphanet:555434", "UMLS:C5681328" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0005151", "name": "endocrine system disorder" } ], "definition": "A subtype of inflammatory pseudotumor of the liver characterized by a benign, well-circumscribed tumor with fibrohistiocytic infiltration (including xanthogranulomatous inflammation, multinucleated giant cells, and neutrophilic infiltration), typically localized in the peripheral hepatic parenchyma. Presentation may be of non-specific symptoms (fever, malaise, and abdominal pain) or as an incidental finding." }, "child_count": 0, "reference_id": "MONDO:0035312" }, { "id": 22820, "label": "lymphoplasmacytic inflammatory pseudotumor of the liver", "isLeaf": true, "isRoot": false, "parents": [ 21432 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0022240", "ICD10CM:K75.8", "MEDGEN:1843135", "Orphanet:555437", "UMLS:C5680170" ], "synonyms": [ "IgG4-related inflammatory pseudotumor of the liver" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0005151", "name": "endocrine system disorder" } ], "definition": "A subtype of inflammatory pseudotumor of the liver characterized by a benign, well-circumscribed tumor with diffuse lymphoplasmacytic infiltration with histological features of IgG4-related disease (numerous IgG4-positive plasma cells, prominent eosinophils, stromal fibrosis, fibroblastic proliferations and, frequently, obliterative phlebitis), and that is likely located around the hepatic hilum. Most often it is discovered as an incidental finding." }, "child_count": 0, "reference_id": "MONDO:0035313" }, { "id": 22849, "label": "liver adenomatosis", "isLeaf": true, "isRoot": false, "parents": [ 21432 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0022278", "ICD10CM:D13.4", "MEDGEN:1803906", "Orphanet:566841", "UMLS:C5680136" ], "synonyms": [ "Hepatic adenomatosis" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0005151", "name": "endocrine system disorder" } ], "definition": "A rare neoplastic disease characterized by the presence of ten or more hepatocellular adenomas in a background of normal appearing hepatic parenchyma. The majority of reported cases are female. There is no association with steroid use. The condition is considered benign, although the risk of complications (such as malignant transformation or spontaneous rupture with intraperitoneal hemorrhage) is much higher than in isolated hepatic adenoma. Hepatocellular carcinoma develops in less than 10% of cases." }, "child_count": 0, "reference_id": "MONDO:0035447" } ], "roots": [ { "id": 4223, "label": "endocrine gland neoplasm" }, { "id": 4585, "label": "hepatobiliary neoplasm" }, { "id": 6878, "label": "liver disorder" } ] }