{
  "id": 21453,
  "label": "duodenal neuroendocrine neoplasm",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0024500",
  "properties": {
    "xrefs": [
      "GARD:0025403",
      "MEDGEN:1800031",
      "UMLS:C5568608",
      "icd11.foundation:1585809486"
    ],
    "synonyms": [
      "duodenum NET",
      "duodenum neuroendocrine neoplasm",
      "duodenum neuroendocrine tumor",
      "duodenum neuroendocrine tumor, well differentiated, low or intermediate grade",
      "duodenum neuroendocrine tumour",
      "neuroendocrine neoplasm of duodenum"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A neuroendocrine neoplasm that involves the duodenum."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 18542,
      "label": "small intestine neuroendocrine neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4896,
        6071
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4434",
          "EFO:1001928",
          "GARD:0021765",
          "MEDGEN:233453",
          "NCIT:C5803",
          "Orphanet:423975",
          "UMLS:C1336005"
        ],
        "synonyms": [
          "NET of the small intestine",
          "neuroendocrine neoplasm of small intestine",
          "neuroendocrine neoplasm of the small intestine",
          "neuroendocrine tumor of small bowel",
          "neuroendocrine tumour of small bowel",
          "small intestinal neuroendocrine neoplasm",
          "small intestine NET",
          "small intestine neuroendocrine neoplasm",
          "small intestine neuroendocrine tumor",
          "small intestine neuroendocrine tumour",
          "neuroendocrine tumor of the small intestine",
          "neuroendocrine tumour of the small intestine",
          "small intestine neuroendocrine tumor, well differentiated, low or intermediate grade"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A neoplasm with neuroendocrine differentiation that arises from the small intestine. It includes well differentiated neuroendocrine tumors (low and intermediate grade) and poorly differentiated neuroendocrine carcinomas (high grade)."
      },
      "child_count": 6,
      "reference_id": "MONDO:0018510"
    },
    {
      "id": 20534,
      "label": "tumor of duodenum",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4880,
        6071
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:8503",
          "NCIT:C2995",
          "SCTID:126833009",
          "UMLS:C0013291"
        ],
        "synonyms": [
          "duodenal neoplasm",
          "duodenal tumor",
          "duodenal tumour",
          "duodenum neoplasm",
          "duodenum neoplasm (disease)",
          "duodenum tumor",
          "duodenum tumour",
          "neoplasm of duodenum",
          "neoplasm of the duodenum",
          "tumor of duodenum",
          "tumor of the duodenum",
          "tumour of the duodenum"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A neoplasm (disease) that involves the duodenum."
      },
      "child_count": 12,
      "reference_id": "MONDO:0021375"
    }
  ],
  "children": [
    {
      "id": 5949,
      "label": "ampulla of vater small cell neuroendocrine carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2894,
        16046,
        17870,
        21453
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7136",
          "GARD:0023833",
          "MEDGEN:233974",
          "NCIT:C6655",
          "UMLS:C1332250"
        ],
        "synonyms": [
          "ampulla of Vater small cell NEC",
          "ampulla of Vater small cell carcinoma",
          "ampulla of Vater small cell neuroendocrine carcinoma",
          "ampullary small cell carcinoma",
          "hepatopancreatic ampulla small cell carcinoma",
          "small cell neuroendocrine carcinoma of the ampullary region"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An aggressive neuroendocrine carcinoma arising from the ampulla of Vater and the periampullary region. Morphologically, it is characterized by the presence of small malignant cells, necrosis, and a high mitotic rate. Signs and symptoms include jaundice, abdominal pain, anorexia, nausea, vomiting, and weight loss."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004117"
    },
    {
      "id": 16037,
      "label": "duodenal neuroendocrine tumor, well differentiated, low or intermediate grade",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4994,
        21453
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019751",
          "MEDGEN:1619951",
          "NCIT:C135080",
          "Orphanet:100076",
          "UMLS:C4525619"
        ],
        "synonyms": [
          "duodenal neuroendocrine tumor",
          "duodenal neuroendocrine tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A well differentiated, low or intermediate grade tumor with neuroendocrine differentiation that arises from the duodenum."
      },
      "child_count": 4,
      "reference_id": "MONDO:0015063"
    }
  ],
  "roots": [
    {
      "id": 18542,
      "label": "small intestine neuroendocrine neoplasm"
    },
    {
      "id": 20534,
      "label": "tumor of duodenum"
    }
  ]
}