{
  "id": 21456,
  "label": "digestive system neuroendocrine neoplasm",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0024503",
  "properties": {
    "xrefs": [
      "GARD:0002437",
      "MEDGEN:232237",
      "MESH:C535650",
      "NCIT:C27721",
      "Orphanet:100092",
      "UMLS:C1333799"
    ],
    "synonyms": [
      "alimentary part of gastrointestinal system NET",
      "alimentary part of gastrointestinal system neuroendocrine neoplasm",
      "alimentary part of gastrointestinal system neuroendocrine tumor",
      "alimentary part of gastrointestinal system neuroendocrine tumor, well differentiated, low or intermediate grade",
      "alimentary part of gastrointestinal system neuroendocrine tumour",
      "carcinoid tumor of digestive system",
      "carcinoid tumour of digestive system",
      "digestive system NET",
      "digestive system neuroendocrine neoplasm",
      "digestive system neuroendocrine tumor",
      "digestive system neuroendocrine tumor, well differentiated, low or intermediate grade",
      "digestive system neuroendocrine tumour",
      "gastro-enteropancreatic neuroendocrine tumor",
      "gastro-enteropancreatic neuroendocrine tumour",
      "gastroenteropancreatic endocrine tumor",
      "gastroenteropancreatic endocrine tumour",
      "gastroenteropancreatic neuroendocrine neoplasm",
      "gastrointestinal neuroendocrine neoplasm",
      "gastrointestinal system neuroendocrine neoplasm",
      "neuroendocrine neoplasm of alimentary part of gastrointestinal system",
      "neuroendocrine neoplasm of digestive system",
      "GEP tumors",
      "GEP tumours",
      "GEP-NEN",
      "GEP-NET",
      "carcinoid tumor",
      "carcinoid tumour"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A neoplasm with neuroendocrine differentiation arising from the digestive system. It includes neuroendocrine tumors (well-differentiated endocrine tumors or carcinoid tumors and well differentiated endocrine carcinomas) and neuroendocrine carcinomas (poorly differentiated neuroendocrine carcinomas, small cell carcinomas, and large cell neuroendocrine carcinomas)."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 7,
  "parents": [
    {
      "id": 6151,
      "label": "digestive system disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29379
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:77",
          "ICD10CM:K00-K95",
          "ICD9:520-579",
          "ICD9:V47.3",
          "MEDGEN:892790",
          "MESH:D005767",
          "NANDO:1100013",
          "NCIT:C2990",
          "SCTID:53619000",
          "UMLS:C4023588",
          "icd11.foundation:1256772020"
        ],
        "synonyms": [
          "digestive disease",
          "digestive system disease",
          "digestive system disease or disorder",
          "digestive system disorder",
          "disease of digestive system",
          "disease or disorder of digestive system",
          "disorder of digestive system",
          "gastroenterological system disease",
          "gastroenterological system disorder",
          "gastrointestinal disorder",
          "gastrointestinal system disease",
          "gastrointestinal system disorder",
          "stomach or intestinal disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A disease or disorder that involves the digestive system."
      },
      "child_count": 31,
      "reference_id": "MONDO:0004335"
    },
    {
      "id": 19314,
      "label": "neuroendocrine neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4223
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:169",
          "EFO:1001901",
          "GARD:0009316",
          "ICD9:209",
          "ICD9:209-209",
          "ICD9:239.7",
          "MEDGEN:64652",
          "MESH:D018358",
          "NCIT:C188218",
          "NCIT:C3809",
          "Orphanet:877",
          "SCTID:255046005",
          "UMLS:C0206754"
        ],
        "synonyms": [
          "APUDoma",
          "neuroendocrine neoplasm",
          "neuroendocrine tumor",
          "neuroendocrine tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Endocrine tumors, also referred to as neuroendocrine tumors (NETs), are defined by a common phenotype which is characterized by the expression of general markers (neuron specific enolase, chromogranin, synaptophysin) and hormone secretion products. These tumors may be localized in any part of the body and are generally discovered in non-specific situations, i.e. not immediately suggestive of NETs (tests for inherited predisposition to tumors or for a clinical syndrome caused by abnormal hormone secretion)."
      },
      "child_count": 14,
      "reference_id": "MONDO:0019496"
    },
    {
      "id": 20434,
      "label": "digestive system neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6798
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0008549",
          "MEDGEN:8398",
          "MESH:D005770",
          "NCIT:C3052",
          "UMLS:C0012243"
        ],
        "synonyms": [
          "GI neoplasm",
          "GI system neoplasm",
          "GI system tumor",
          "GI system tumour",
          "GI tumor",
          "GI tumour",
          "digestive neoplasm",
          "digestive system neoplasm (disease)",
          "digestive system tumor",
          "digestive system tumour",
          "digestive tumor",
          "digestive tumour",
          "gastrointestinal neoplasm",
          "gastrointestinal system neoplasm",
          "gastrointestinal system tumor",
          "gastrointestinal system tumour",
          "gastrointestinal tumor",
          "gastrointestinal tumour",
          "neoplasm of GI system",
          "neoplasm of digestive system",
          "neoplasm of gastrointestinal system",
          "neoplasm of the GI system",
          "neoplasm of the digestive system",
          "neoplasm of the gastrointestinal system",
          "tumor of GI system",
          "tumor of digestive system",
          "tumor of gastrointestinal system",
          "tumor of the GI system",
          "tumor of the digestive system",
          "tumor of the gastrointestinal system",
          "tumour of GI system",
          "tumour of digestive system",
          "tumour of gastrointestinal system",
          "tumour of the GI system",
          "tumour of the digestive system",
          "tumour of the gastrointestinal system"
        ],
        "definition": "A neoplasm (disease) that involves the digestive system."
      },
      "child_count": 23,
      "reference_id": "MONDO:0021223"
    }
  ],
  "children": [
    {
      "id": 2885,
      "label": "digestive system neuroendocrine tumor, grade 1/2",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        21456
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050626",
          "GARD:0022761",
          "MEDGEN:443945",
          "NCIT:C95404",
          "ONCOTREE:GINET",
          "UMLS:C2930967"
        ],
        "synonyms": [
          "alimentary part of gastrointestinal system neuroendocrine tumor",
          "alimentary part of gastrointestinal system neuroendocrine tumour",
          "digestive system NET",
          "digestive system neuroendocrine tumor",
          "digestive system neuroendocrine tumour",
          "digestive system well differentiated neuroendocrine tumor",
          "digestive system well differentiated neuroendocrine tumour",
          "gastroenteropancreatic NET",
          "gastroenteropancreatic neuroendocrine tumor",
          "gastroenteropancreatic neuroendocrine tumour",
          "gastrointestinal NET",
          "gastrointestinal neuroendocrine tumor",
          "gastrointestinal neuroendocrine tumors",
          "gastrointestinal neuroendocrine tumour",
          "gastrointestinal neuroendocrine tumours",
          "gastrointestinal system neuroendocrine tumor",
          "gastrointestinal system neuroendocrine tumour",
          "malignant gastrointestinal neuroendocrine tumor",
          "malignant gastrointestinal neuroendocrine tumour",
          "GINET"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A well-differentiated neuroendocrine tumor arising from the digestive system. It is characterized by the presence of cells with features similar to those of the normal endocrine cells of the digestive system. The neoplastic cells express immunohistochemical evidence of neuroendocrine differentiation and hormones. There is mild to moderate nuclear atypia and less than 20 mitoses per 10 HPF. It includes well-differentiated endocrine tumors or carcinoid tumors and well-differentiated endocrine carcinomas."
      },
      "child_count": 10,
      "reference_id": "MONDO:0000386"
    },
    {
      "id": 4896,
      "label": "intestinal neuroendocrine neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20357,
        21456
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4119",
          "GARD:0023287",
          "MEDGEN:233567",
          "NCIT:C5695",
          "UMLS:C1334231"
        ],
        "synonyms": [
          "intestinal neuroendocrine neoplasm",
          "intestine NET",
          "intestine neuroendocrine neoplasm",
          "intestine neuroendocrine tumor",
          "intestine neuroendocrine tumor, well differentiated, low or intermediate grade",
          "intestine neuroendocrine tumour",
          "neuroendocrine neoplasm of intestine",
          "neuroendocrine neoplasm of the intestine",
          "intestinal neuroendocrine benign tumor",
          "intestinal neuroendocrine benign tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A neoplasm with neuroendocrine differentiation that arises from the small or large intestine. It includes well differentiated neuroendocrine tumors (low and intermediate grade) and poorly differentiated neuroendocrine carcinomas (high grade)."
      },
      "child_count": 8,
      "reference_id": "MONDO:0002883"
    },
    {
      "id": 5092,
      "label": "gastric neuroendocrine neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20326,
        21456
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4715",
          "GARD:0019750",
          "MEDGEN:232548",
          "NCIT:C5696",
          "Orphanet:100075",
          "SCTID:721194008",
          "UMLS:C1333783"
        ],
        "synonyms": [
          "NET of stomach",
          "gastric neuroendocrine neoplasm",
          "neuroendocrine neoplasm of stomach",
          "neuroendocrine neoplasm of the stomach",
          "neuroendocrine tumour of the stomach",
          "stomach NET",
          "stomach neuroendocrine neoplasm",
          "stomach neuroendocrine tumor",
          "stomach neuroendocrine tumor, well differentiated, low or intermediate grade",
          "stomach neuroendocrine tumour",
          "neuroendocrine tumor of stomach",
          "neuroendocrine tumour of stomach"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A neoplasm with neuroendocrine differentiation that arises from the stomach. It includes well differentiated neuroendocrine tumors (low and intermediate grade) and poorly differentiated neuroendocrine carcinomas (high grade)."
      },
      "child_count": 4,
      "reference_id": "MONDO:0003111"
    },
    {
      "id": 7431,
      "label": "pancreatic neuroendocrine neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4104,
        20285,
        21456
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1799",
          "EFO:0007331",
          "GARD:0022052",
          "ICDO:8150/1",
          "MEDGEN:1848937",
          "NCIT:C27031",
          "Orphanet:506052",
          "SCTID:254611009",
          "UMLS:C5848399",
          "icd11.foundation:1421495979"
        ],
        "synonyms": [
          "PNEN",
          "endocrine pancreas neoplasm",
          "endocrine pancreas neoplasm (disease)",
          "endocrine pancreas tumor",
          "endocrine pancreas tumour",
          "neoplasm of endocrine pancreas",
          "pancreatic NEN",
          "pancreatic endocrine neoplasm",
          "pancreatic neuroendocrine neoplasm",
          "tumor of endocrine pancreas",
          "tumour of endocrine pancreas",
          "Islet cell tumors",
          "Islet cell tumours",
          "endocrine pancreas cancer",
          "islet cell neoplasm",
          "islet cell tumor",
          "islet cell tumour",
          "malignant pancreatic endocrine tumor",
          "malignant pancreatic endocrine tumour",
          "Islet of Langerhans tumor",
          "Islet of Langerhans tumour",
          "neuroendocrine neoplasm of pancreas"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A neoplasm with neuroendocrine differentiation that arises from the pancreas. It includes neuroendocrine tumors (low and intermediate grade) and neuroendocrine carcinomas (high grade)."
      },
      "child_count": 6,
      "reference_id": "MONDO:0005815"
    },
    {
      "id": 7924,
      "label": "salivary gland small cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2894,
        2972,
        21456
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000519",
          "GARD:0024400",
          "MEDGEN:234786",
          "NCIT:C35703",
          "UMLS:C1335982"
        ],
        "synonyms": [
          "anaplastic small cell carcinoma of salivary gland",
          "anaplastic small cell carcinoma of the salivary gland",
          "neuroendocrine carcinoma of salivary gland",
          "neuroendocrine carcinoma of the salivary gland",
          "saliva-secreting gland small cell carcinoma",
          "salivary gland anaplastic small cell carcinoma",
          "salivary gland small cell carcinoma",
          "small cell carcinoma of saliva-secreting gland",
          "small cell salivary gland carcinoma",
          "salivary gland neuroendocrine carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ],
        "definition": "An infrequent small cell carcinoma that arises from the salivary glands and is characterized by the presence of a high number of mitotic figures."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006405"
    },
    {
      "id": 16046,
      "label": "liver neuroendocrine carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4255,
        18551,
        21456
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019760",
          "MEDGEN:474664",
          "NCIT:C96787",
          "Orphanet:100085",
          "SCTID:716652006",
          "UMLS:C3273031"
        ],
        "synonyms": [
          "HNEC",
          "PHNEC",
          "hepatic neuroendocrine carcinoma",
          "liver neuroendocrine cancer",
          "liver neuroendocrine carcinoma",
          "neuroendocrine carcinoma of liver",
          "primary hepatic neuroendocrine carcinoma",
          "primary liver neuroendocrine carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An extremely rare, aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the liver."
      },
      "child_count": 6,
      "reference_id": "MONDO:0015072"
    },
    {
      "id": 21455,
      "label": "gallbladder neuroendocrine neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20460,
        21456
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025405",
          "MEDGEN:474748",
          "NCIT:C96917",
          "UMLS:C3273115"
        ],
        "synonyms": [
          "gall bladder NET",
          "gall bladder neuroendocrine neoplasm",
          "gall bladder neuroendocrine tumor",
          "gall bladder neuroendocrine tumor, well differentiated, low or intermediate grade",
          "gall bladder neuroendocrine tumour",
          "gallbladder neuroendocrine neoplasm",
          "neuroendocrine neoplasm of gall bladder"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A neoplasm with neuroendocrine differentiation that arises from the gallbladder. It includes well differentiated neuroendocrine tumors (low and intermediate grade) and poorly differentiated neuroendocrine carcinomas (high grade)."
      },
      "child_count": 4,
      "reference_id": "MONDO:0024502"
    }
  ],
  "roots": [
    {
      "id": 6151,
      "label": "digestive system disorder"
    },
    {
      "id": 19314,
      "label": "neuroendocrine neoplasm"
    },
    {
      "id": 20434,
      "label": "digestive system neoplasm"
    }
  ]
}